CH231010A - Process for the preparation of B- (p-oxyphenyl) -isopropyl-ethylamine. - Google Patents

Process for the preparation of B- (p-oxyphenyl) -isopropyl-ethylamine.

Info

Publication number
CH231010A
CH231010A CH231010DA CH231010A CH 231010 A CH231010 A CH 231010A CH 231010D A CH231010D A CH 231010DA CH 231010 A CH231010 A CH 231010A
Authority
CH
Switzerland
Prior art keywords
oxyphenyl
ethylamine
isopropyl
preparation
isopropylamine
Prior art date
Application number
Other languages
German (de)
Inventor
Fabriken Knoll Ag Chemische
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of CH231010A publication Critical patent/CH231010A/en

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Description

  

      Ver    fahr     eri    zur Herstellung von     ss-(p-Oxyphenyl)-isopropyl-äthylamin.       Nach     demVerfahren    des Hauptpatentes kann       ss    - (p -     Oxyphenyl)    -     isopropylmethylamin,    ein  wirksames     Kreislaufmittel,    dadurch hergestellt  werden, dass     P-    (p -     Oxyphenyl)-isopropylamin     mit     methylierenden        Mitteln    behandelt wird.  



  Es wurde nun weiterhin gefunden, dass man  durch Ersatz der     Methylgruppe    am Stickstoff  atom der nach dem Hauptpatent     herzustellenden     Verbindung durch die     Xthylgruppe    ebenfalls ein  Arzneimittel erhält, das auf den Kreislauf     bezw.     auf die Atmungsorgane günstig einwirkt.  



  Gegenstand des     vorliegenden    Patentes ist  ein Verfahren zur Herstellung von     f-(p-Oxy-          phenyl)-isopropyl-äthylamin,    welches dadurch  gekennzeichnet ist, dass man     ss-(p-Oxyphenyl)-          isopropylamin    mit     Äthylierungsmitteln    be  handelt. Beispielsweise kann es mit     Benzal-          dehyd    zweckmässig zunächst zur Schiffsehen  Base kondensiert und letztere mit z. B.     Di-          äthylsulfat    oder Jodäthyl behandelt werden.  Die neue Verbindung soll als Arzneimittel  verwendet werden.  



  <I>Beispiel:</I>  15,1 g     P-(p-Oxyphenyl)-isopropylamin    wer  den mit 14 g     Benzaldehyd    auf dem Wasser-         bad        erwärmt.    Nach Entfernen des bei der  Kondensation entstandenen Wassers werden  18 g     Diäthylsulfat    zugegeben und das Ganze  kurze Zeit auf<B>160-1701</B> erhitzt. Das Reak  tionsprodukt wird nun mit     verdünnter    Salz  säure zersetzt,     ausgeäthert    und das gebildete       @-(p-Oxyphenyl)--isopropyl-äthylamin    mit     Ka-          liumcarbonatlösung    gefällt.

   Die erhaltene Base  kann aus verdünntem     Alkohol    umgelöst wer  den; sie bildet farblose     Kristalle    und schmilzt  bei 102-104  . Das Sulfat der Base kristal  lisiert aus Alkohol und zersetzt sich bei 310  .



      Ver fahr eri for the production of ss- (p-oxyphenyl) -isopropyl-ethylamine. According to the process of the main patent, ss - (p - oxyphenyl) - isopropylmethylamine, a potent circulatory agent, can be prepared by treating P- (p - oxyphenyl) isopropylamine with methylating agents.



  It has now also been found that by replacing the methyl group on the nitrogen atom of the compound to be prepared according to the main patent by the xthyl group, a drug that responds to the cycle is also obtained. has a beneficial effect on the respiratory organs.



  The subject of the present patent is a process for the preparation of f- (p-oxyphenyl) -isopropyl-ethylamine, which is characterized in that ss- (p-oxyphenyl) -isopropylamine is treated with ethylating agents. For example, it can expediently first condensed with benzaldehyde to give the ship's base and the latter with z. B. Diet äthylsulfat or iodoethyl be treated. The new compound is intended to be used as a medicine.



  <I> Example: </I> 15.1 g of P- (p-oxyphenyl) -isopropylamine are heated with 14 g of benzaldehyde on a water bath. After removing the water formed during the condensation, 18 g of diethyl sulfate are added and the whole thing is heated to 160-1701 for a short time. The reaction product is now decomposed with dilute hydrochloric acid, extracted with ether and the @ - (p-oxyphenyl) - isopropylethylamine formed is precipitated with potassium carbonate solution.

   The base obtained can be redissolved from dilute alcohol to who; it forms colorless crystals and melts at 102-104. The sulfate of the base crystallizes from alcohol and decomposes at 310.

Claims (1)

<B>PATENTANSPRUCH</B> Verfahren zur Herstellung von @-(p-Oxy- phenyl)-isopropyl-äthylamin, dadurch gekenn zeichnet, dass man P-(p-Oxyphenyl)-isopropyl- amin mit Äthylierungsmitteln behandelt. Die neue Base bildet farblose Kristalle, die in organischen Lösungsmitteln löslich sind und bei 102-104 schmelzen. Das Sulfat der Base kri stallisiert aus Alkohol und zersetzt sich bei 310 . <B> PATENT CLAIM </B> Process for the production of @ - (p-oxyphenyl) -isopropyl-ethylamine, characterized in that P- (p-oxyphenyl) -isopropylamine is treated with ethylating agents. The new base forms colorless crystals that are soluble in organic solvents and melt at 102-104. The sulfate of the base crystallizes from alcohol and decomposes at 310.
CH231010D 1936-12-31 1937-12-27 Process for the preparation of B- (p-oxyphenyl) -isopropyl-ethylamine. CH231010A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE231010X 1936-12-31
CH205011T 1937-12-27

Publications (1)

Publication Number Publication Date
CH231010A true CH231010A (en) 1944-02-15

Family

ID=25724107

Family Applications (1)

Application Number Title Priority Date Filing Date
CH231010D CH231010A (en) 1936-12-31 1937-12-27 Process for the preparation of B- (p-oxyphenyl) -isopropyl-ethylamine.

Country Status (1)

Country Link
CH (1) CH231010A (en)

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