CA954858A - Pyridyl oxadiazole derivatives and process for the preparation thereof and pharmaceutical compositions containing same - Google Patents

Pyridyl oxadiazole derivatives and process for the preparation thereof and pharmaceutical compositions containing same

Info

Publication number
CA954858A
CA954858A CA049,755A CA49755A CA954858A CA 954858 A CA954858 A CA 954858A CA 49755 A CA49755 A CA 49755A CA 954858 A CA954858 A CA 954858A
Authority
CA
Canada
Prior art keywords
pyridyl
preparation
pharmaceutical compositions
compositions containing
containing same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA049,755A
Other languages
English (en)
Inventor
Csaba Gonczi
Gyorgy Leszkovszky
Erzsebet Bako
Kalman Takacs
Kalman Harsanyi
Dezso Korbonits
Csaba Vertesy
Jozsef Reiter
Laszlo Tardos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Application granted granted Critical
Publication of CA954858A publication Critical patent/CA954858A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
CA049,755A 1968-04-26 1969-04-25 Pyridyl oxadiazole derivatives and process for the preparation thereof and pharmaceutical compositions containing same Expired CA954858A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI000796 1968-04-26

Publications (1)

Publication Number Publication Date
CA954858A true CA954858A (en) 1974-09-17

Family

ID=10994349

Family Applications (1)

Application Number Title Priority Date Filing Date
CA049,755A Expired CA954858A (en) 1968-04-26 1969-04-25 Pyridyl oxadiazole derivatives and process for the preparation thereof and pharmaceutical compositions containing same

Country Status (15)

Country Link
US (1) US3647809A (de)
JP (1) JPS4824394B1 (de)
AT (2) AT292728B (de)
BE (1) BE732131A (de)
BR (1) BR6908381D0 (de)
CA (1) CA954858A (de)
CH (2) CH542232A (de)
DE (1) DE1920037A1 (de)
FR (1) FR2007529B1 (de)
GB (1) GB1271302A (de)
IL (1) IL31990A (de)
NL (1) NL6906401A (de)
NO (1) NO124253B (de)
PL (1) PL79435B1 (de)
SE (1) SE368576B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853893A (en) * 1973-04-02 1974-12-10 Squibb & Sons Inc Anthelmintic 5-(pyridyl)-3-(isothiocyanophenyl) oxadiazoles
HU177086B (en) * 1975-06-09 1981-07-28 Eszakmagyar Vegyimuevek Herbicide and fungicide preparation containing substituted 1,2,4-oxadiazolidin-3-one derivatives
JPS58150576A (ja) * 1982-03-03 1983-09-07 Sumitomo Chem Co Ltd 新規な１，２，４−オキサジアゾ−ル誘導体
DE3247118A1 (de) * 1982-12-20 1984-06-20 Cassella Ag, 6000 Frankfurt Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
PL353825A1 (en) * 1999-08-19 2003-12-01 Nps Pharmaceuticals, Inc.Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
EP1582519A3 (de) * 1999-08-19 2005-12-21 Nps Pharmaceuticals, Inc. Heteropolycyclische verbindungen und ihre verwendung als antagonisten von metabotropen glutamatrezeptoren
EP1379525B1 (de) * 2001-02-21 2007-10-10 Nps Pharmaceuticals, Inc. Heteropolycyclische verbindungen und deren verwendung als metabotrope glutamatrezeptorantagonisten
WO2004014902A2 (en) * 2002-08-09 2004-02-19 Astrazeneca Ab Compounds having an activity at metabotropic glutamate receptors
AU2004229392A1 (en) * 2003-04-09 2004-10-28 Exelixis, Inc. Tie-2 modulators and methods of use
JP2006528980A (ja) * 2003-05-15 2006-12-28 メルク　エンド　カムパニー　インコーポレーテッド Ｓ１ｐ受容体作働薬としての３−（２−アミノ−１−アザシクロ）−５−アリール−１，２，４−オキサジアゾール類
US20060189661A1 (en) * 2003-11-03 2006-08-24 Wagenen Bradford V Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
WO2005060961A2 (en) * 2003-12-18 2005-07-07 Astrazeneca Ab Treatment of transient lower esophageal sphincter relaxations (tlesrs) and gastro-esophageal reflux disease (gerd)
WO2005061489A1 (en) * 2003-12-24 2005-07-07 Prosidion Limited Heterocyclic derivatives as gpcr receptor agonists
WO2005077368A2 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
WO2006114400A1 (en) * 2005-04-26 2006-11-02 Neurosearch A/S Novel oxadiazole derivatives and their medical use
IL169855A (en) * 2005-07-25 2014-05-28 Elta Systems Ltd A system and method for locating a receiver location
US8168793B2 (en) 2005-07-26 2012-05-01 Portela & Ca., S.A. Nitrocatechol derivatives as COMT inhibitors
EP1845097A1 (de) 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazolderivate als COMT Inihibitoren
PL2069336T3 (pl) * 2006-09-07 2013-05-31 Idorsia Pharmaceuticals Ltd Pochodne pirydyn-4-ylu jako środki immunomodulujące
AU2007292992B2 (en) * 2006-09-08 2013-01-10 Actelion Pharmaceuticals Ltd Pyridin-3-yl derivatives as immunomodulating agents
PL2481410T3 (pl) * 2007-01-31 2017-03-31 Bial - Portela & Ca., S.A. Pochodne nitrokatecholu jako inhibitory COMT podawane w określonym schemacie dawkowania
SI2125797T1 (sl) * 2007-03-16 2014-03-31 Actelion Pharmaceuticals Ltd. Derivati amino-piridina kot agonisti receptorja s1p1/edg1
ES2361463T3 (es) * 2007-08-17 2011-06-17 Actelion Pharmaceuticals Ltd. Derivados de piridina como moduladores del receptor s1p1/edg1.
EP2259777A2 (de) * 2008-02-28 2010-12-15 BIAL - Portela & Ca., S.A. Pharmazeutische zusammensetzung für schwer lösliche arzneimittel
CA2714665A1 (en) * 2008-03-06 2009-09-11 Actelion Pharmaceuticals Ltd Pyridine compounds
HRP20130641T1 (en) * 2008-03-07 2013-08-31 Actelion Pharmaceuticals Ltd. Pyridin-2-yl derivatives as immunomodulating agents
CL2009000628A1 (es) 2008-03-17 2010-04-09 Bial Portela & Companhia S A Forma cristalina de 5-[3-(2,5-dicloro-4,6-dimetil-1-oxi-piridin-3-il)-[1,2,4]oxadiazol-5-il]-3-nitrobenceno-1,2-diol, composicion farmaceutica que la comprende, proceso para obtenerla y su uso para tratar trastornos del animo, enfermedad de parkinson y trastornos parkinsonianos, alteraciones gastrointestinales, entre otros.
EP2913326B1 (de) 2008-05-14 2020-07-15 The Scripps Research Institute Neue modulatoren von sphingosinphosphatrezeptoren
EP3587413A1 (de) 2009-02-10 2020-01-01 Monsanto Technology LLC Zusammensetzungen und verfahren zur kontrolle von nematoden
US9132094B2 (en) 2009-04-01 2015-09-15 Bial—Portela & Ca, S.A. Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof
US20100256194A1 (en) * 2009-04-01 2010-10-07 Bial - Portela & Ca, S.A. Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making the same
WO2011007324A1 (en) 2009-07-16 2011-01-20 Actelion Pharmaceuticals Ltd Pyridin-4-yl derivatives
UA109804C2 (xx) 2011-01-19 2015-10-12 2-метоксипіридин-4-ільні похідні
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
PT2791134T (pt) 2011-12-13 2019-12-18 BIAL PORTELA & Cª S A Composto químico útil como intermediário para a preparação de um inibidor de catecol-o-metiltransferase
BR112015019643A8 (pt) * 2013-02-15 2019-11-05 Monsanto Technology Llc compostos de 3,5-dissubstituído-4,5-di-hidro-1,2,4-oxadiazol, composição nematicida aquosa, semente e método para controlar nematódeos indesejáveis
RU2017120184A (ru) 2014-11-28 2018-12-28 БИАЛ - ПОРТЕЛА ЭНД Ка, С.А. Лекарства для замедления течения болезни паркинсона
MY192358A (en) 2015-05-20 2022-08-17 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL256329A (de) * 1959-09-29
US3227725A (en) * 1962-04-17 1966-01-04 Union Carbide Corp Certain 3,5-disubstituted 1,2,4-oxadiazole compounds

Also Published As

Publication number Publication date
GB1271302A (en) 1972-04-19
BR6908381D0 (pt) 1973-02-08
FR2007529A1 (de) 1970-01-09
SE368576B (de) 1974-07-08
BE732131A (de) 1969-10-01
FR2007529B1 (de) 1973-03-16
IL31990A0 (en) 1969-06-25
DE1920037A1 (de) 1970-11-12
CH542232A (de) 1973-11-15
NL6906401A (de) 1969-10-28
AT292727B (de) 1971-09-10
JPS4824394B1 (de) 1973-07-20
PL79435B1 (en) 1975-06-30
IL31990A (en) 1974-05-16
CH540925A (de) 1973-08-31
NO124253B (de) 1972-03-27
US3647809A (en) 1972-03-07
AT292728B (de) 1971-09-10

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