CA3254460A1 - Assay for Determining Potential to Self-Association of a Protein Using Concentration-Dependent Self-Interaction Nanoparticle Spectroscopy - Google Patents

Assay for Determining Potential to Self-Association of a Protein Using Concentration-Dependent Self-Interaction Nanoparticle Spectroscopy

Info

Publication number
CA3254460A1
CA3254460A1 CA3254460A CA3254460A CA3254460A1 CA 3254460 A1 CA3254460 A1 CA 3254460A1 CA 3254460 A CA3254460 A CA 3254460A CA 3254460 A CA3254460 A CA 3254460A CA 3254460 A1 CA3254460 A1 CA 3254460A1
Authority
CA
Canada
Prior art keywords
self
assay
protein
association
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3254460A
Other languages
English (en)
French (fr)
Inventor
Michael Marlow
Michael Sennett
Michael Schneider
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of CA3254460A1 publication Critical patent/CA3254460A1/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N2021/258—Surface plasmon spectroscopy, e.g. micro- or nanoparticles in suspension

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
CA3254460A 2016-08-18 2017-08-18 Assay for Determining Potential to Self-Association of a Protein Using Concentration-Dependent Self-Interaction Nanoparticle Spectroscopy Pending CA3254460A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662376788P 2016-08-18 2016-08-18
US62/376,788 2016-08-18

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3032361A Division CA3032361C (en) 2016-08-18 2017-08-18 TEST TO DETERMINE THE SELF-ASSOCIATION POTENTIAL OF A PROTEIN BY MEANS OF CONCENTRATION-DEPENDENT SELF-INTERACTION NANOPARTICULAR SPECTROSCOPY

Publications (1)

Publication Number Publication Date
CA3254460A1 true CA3254460A1 (en) 2025-07-03

Family

ID=59746357

Family Applications (3)

Application Number Title Priority Date Filing Date
CA3254460A Pending CA3254460A1 (en) 2016-08-18 2017-08-18 Assay for Determining Potential to Self-Association of a Protein Using Concentration-Dependent Self-Interaction Nanoparticle Spectroscopy
CA3254461A Pending CA3254461A1 (en) 2016-08-18 2017-08-18 Assay for Determining Potential to Self-Association of a Protein Using Concentration-Dependent Self-Interaction Nanoparticle Spectroscopy
CA3032361A Active CA3032361C (en) 2016-08-18 2017-08-18 TEST TO DETERMINE THE SELF-ASSOCIATION POTENTIAL OF A PROTEIN BY MEANS OF CONCENTRATION-DEPENDENT SELF-INTERACTION NANOPARTICULAR SPECTROSCOPY

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA3254461A Pending CA3254461A1 (en) 2016-08-18 2017-08-18 Assay for Determining Potential to Self-Association of a Protein Using Concentration-Dependent Self-Interaction Nanoparticle Spectroscopy
CA3032361A Active CA3032361C (en) 2016-08-18 2017-08-18 TEST TO DETERMINE THE SELF-ASSOCIATION POTENTIAL OF A PROTEIN BY MEANS OF CONCENTRATION-DEPENDENT SELF-INTERACTION NANOPARTICULAR SPECTROSCOPY

Country Status (19)

Country Link
US (3) US11428695B2 (enExample)
EP (2) EP3761035B1 (enExample)
JP (3) JP6959327B2 (enExample)
KR (3) KR102441221B1 (enExample)
CN (2) CN115468919A (enExample)
AU (2) AU2017313150B2 (enExample)
BR (1) BR112019003175A2 (enExample)
CA (3) CA3254460A1 (enExample)
DK (2) DK3500856T3 (enExample)
EA (1) EA201990316A1 (enExample)
ES (2) ES2974961T3 (enExample)
FI (1) FI3761035T3 (enExample)
HU (2) HUE052805T2 (enExample)
IL (2) IL264640B2 (enExample)
MX (2) MX2019001930A (enExample)
PL (2) PL3500856T3 (enExample)
SG (1) SG11201900895QA (enExample)
WO (1) WO2018035470A1 (enExample)
ZA (1) ZA201901035B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201990316A1 (ru) 2016-08-18 2019-07-31 Ридженерон Фармасьютикалз, Инк. Анализ для определения потенциала самоассоциации белка с использованием концентрационно-зависимой спектроскопии самовзаимодействия на основе наночастиц
RS67656B1 (sr) 2018-05-10 2026-02-27 Regeneron Pharma Formulacije koje sadrže visoke koncentracije fuzionog proteina vegf receptora
CN113588582B (zh) * 2020-04-30 2024-05-14 上海药明生物技术有限公司 蛋白质样品浓度测定方式选择法及测定方法
WO2023095154A1 (en) * 2021-11-24 2023-06-01 Sensoville Biotech Pvt Ltd Method for determining changes in a protein's structure
AU2023208644A1 (en) * 2022-01-24 2024-07-04 Amgen Inc. Methods for detecting antibody self-association
CN119832975A (zh) * 2024-12-24 2025-04-15 上海药明生物技术有限公司 一种蛋白质共处方制剂的稳定性预测方法

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US771997A (en) 1903-11-21 1904-10-11 Alfred Palm Lathe attachment.
US4254102A (en) * 1975-09-08 1981-03-03 Plough, Inc. Substantive PABA compositions
US4080264A (en) 1976-03-01 1978-03-21 Massachusetts Institute Of Technology Immunoassay by light scattering spectroscopy
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US20050214356A1 (en) * 2004-03-24 2005-09-29 Joyce Timothy H Self assembling activation agents targeted using active drug release
US20050221507A1 (en) * 2004-03-30 2005-10-06 Intel Corporation Method to detect molecular binding by surface-enhanced Raman spectroscopy
US7514938B2 (en) 2004-05-11 2009-04-07 Board Of Regents Of The University And College System Of Nevada, On Behalf Of The University Of Nevada, Reno Dielectric relaxation spectroscopy apparatus and methods of use
TW200621282A (en) * 2004-08-13 2006-07-01 Wyeth Corp Stabilizing formulations
ES2352509T3 (es) * 2005-05-02 2011-02-21 Baseclick Gmbh Nuevas estrategias de marcaje para la detección sensible de analitos.
US20070291265A1 (en) 2006-04-13 2007-12-20 Mississippi State University Optical apparatus for simultaneously measuring the scattering and concentration of signals of macromolecules in a flow cell
KR20090069330A (ko) * 2006-10-12 2009-06-30 와이어쓰 유백광/응집체를 감소시키기 위한 항체 용액 중의 이온 강도의 변화
GB0621050D0 (en) * 2006-10-23 2006-11-29 Univ Strathclyde Functionalised polymers for labelling metal surfaces
DK2150617T3 (en) 2007-06-04 2015-01-12 Regeneron Pharma Regions with increased expression and stability
JP2011520769A (ja) * 2007-09-21 2011-07-21 サイトイミューン サイエンシズ インコーポレイテッド ナノ治療コロイド金属組成物および方法
WO2010059963A2 (en) 2008-11-21 2010-05-27 The Board Of Regents Of The University Of Texas System Preparation and methodology of silk fibroin nanoparticles
US20140024024A1 (en) * 2012-07-17 2014-01-23 General Electric Company Methods of detecting dna, rna and protein in biological samples
JP6099108B2 (ja) 2013-05-30 2017-03-29 公立大学法人大阪府立大学 被検出物質の検出装置および方法
IL312865B2 (en) * 2013-09-11 2025-06-01 Eagle Biologics Inc Liquid protein formulations containing viscosity-lowering agents
EP2902503A1 (en) * 2014-01-31 2015-08-05 Fundación Imdea Nanociencia Functionalized metal nanoparticles and uses thereof for detecting nucleic acids
WO2015196091A1 (en) * 2014-06-20 2015-12-23 Reform Biologics, Llc Viscosity-reducing excipient compounds for protein formulations
CN104062287B (zh) * 2014-07-01 2017-08-08 福建工程学院 一种基于纳米金催化的化学发光分析检测铁蛋白的方法
MA40861A (fr) 2014-10-31 2017-09-05 Biogen Ma Inc Anticorps anti-glycoprotéines iib/iiia
WO2016115475A1 (en) 2015-01-18 2016-07-21 Biogen Ma Inc. Anti-cd40 antibody formulations
EA201990316A1 (ru) 2016-08-18 2019-07-31 Ридженерон Фармасьютикалз, Инк. Анализ для определения потенциала самоассоциации белка с использованием концентрационно-зависимой спектроскопии самовзаимодействия на основе наночастиц

Also Published As

Publication number Publication date
FI3761035T3 (fi) 2024-03-18
EP3761035B1 (en) 2024-02-14
WO2018035470A9 (en) 2018-07-05
US20240280582A1 (en) 2024-08-22
JP2022008959A (ja) 2022-01-14
MX2023013583A (es) 2023-11-30
KR20190039185A (ko) 2019-04-10
CA3254461A1 (en) 2025-07-03
PL3761035T3 (pl) 2024-06-24
SG11201900895QA (en) 2019-02-27
JP2023139189A (ja) 2023-10-03
ES2837093T3 (es) 2021-06-29
US11988668B2 (en) 2024-05-21
AU2023274236A1 (en) 2023-12-21
MX2019001930A (es) 2019-07-04
CN109661577B (zh) 2022-09-27
IL307435A (en) 2023-12-01
PL3500856T3 (pl) 2021-04-19
EP3500856B1 (en) 2020-10-07
JP7321227B2 (ja) 2023-08-04
US20220357335A1 (en) 2022-11-10
KR20230074614A (ko) 2023-05-30
HUE052805T2 (hu) 2021-05-28
DK3761035T3 (da) 2024-03-11
IL264640B1 (en) 2023-11-01
JP6959327B2 (ja) 2021-11-02
ES2974961T3 (es) 2024-07-02
KR20220126801A (ko) 2022-09-16
KR102534506B1 (ko) 2023-05-30
KR102717462B1 (ko) 2024-10-16
WO2018035470A1 (en) 2018-02-22
EA201990316A1 (ru) 2019-07-31
ZA201901035B (en) 2024-06-26
US20190187149A1 (en) 2019-06-20
JP2019532267A (ja) 2019-11-07
IL264640B2 (en) 2024-03-01
DK3500856T3 (da) 2020-12-14
KR102441221B1 (ko) 2022-09-07
CA3032361A1 (en) 2018-02-22
US11428695B2 (en) 2022-08-30
CN109661577A (zh) 2019-04-19
CN115468919A (zh) 2022-12-13
AU2017313150B2 (en) 2023-09-14
EP3761035A1 (en) 2021-01-06
IL264640A (enExample) 2019-04-30
BR112019003175A2 (pt) 2019-06-18
AU2017313150A1 (en) 2019-02-21
EP3500856A1 (en) 2019-06-26
CA3032361C (en) 2025-07-08
HUE066064T2 (hu) 2024-07-28

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