CA3225293A1 - Solid state forms - Google Patents

Solid state forms

Info

Publication number
CA3225293A1
CA3225293A1 CA3225293A CA3225293A CA3225293A1 CA 3225293 A1 CA3225293 A1 CA 3225293A1 CA 3225293 A CA3225293 A CA 3225293A CA 3225293 A CA3225293 A CA 3225293A CA 3225293 A1 CA3225293 A1 CA 3225293A1
Authority
CA
Canada
Prior art keywords
compound
crystalline
present disclosure
cancer
disclosure provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3225293A
Other languages
English (en)
Inventor
Mary Chaves
Patricia Lopez
Prashant Agarwal
Albert Amegadzie
Stephanie AZALI
Roman SHIMANOVICH
Ron C. Kelly
Darren Leonard REID
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA3225293A1 publication Critical patent/CA3225293A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
CA3225293A 2019-05-21 2020-05-20 Solid state forms Pending CA3225293A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962851044P 2019-05-21 2019-05-21
US62/851,044 2019-05-21
CA3140392A CA3140392C (en) 2019-05-21 2020-05-20 Solid state forms

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3140392A Division CA3140392C (en) 2019-05-21 2020-05-20 Solid state forms

Publications (1)

Publication Number Publication Date
CA3225293A1 true CA3225293A1 (en) 2020-11-26

Family

ID=71083699

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3225293A Pending CA3225293A1 (en) 2019-05-21 2020-05-20 Solid state forms
CA3140392A Active CA3140392C (en) 2019-05-21 2020-05-20 Solid state forms

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3140392A Active CA3140392C (en) 2019-05-21 2020-05-20 Solid state forms

Country Status (24)

Country Link
US (5) US11236091B2 (https=)
EP (1) EP3972973A1 (https=)
JP (4) JP7092935B2 (https=)
KR (2) KR20250159270A (https=)
CN (2) CN114144414B (https=)
AR (1) AR118978A1 (https=)
AU (2) AU2020280024C1 (https=)
BR (1) BR112021023277A2 (https=)
CA (2) CA3225293A1 (https=)
CL (2) CL2021003064A1 (https=)
CO (1) CO2021017366A2 (https=)
CR (2) CR20250252A (https=)
IL (1) IL288077A (https=)
JO (1) JOP20210310A1 (https=)
MX (1) MX2021014126A (https=)
NZ (1) NZ782284A (https=)
PE (1) PE20220504A1 (https=)
PH (1) PH12021552922A1 (https=)
SA (1) SA521430905B1 (https=)
SG (1) SG11202112855WA (https=)
TW (2) TW202110835A (https=)
UA (1) UA129871C2 (https=)
UY (1) UY38710A (https=)
WO (1) WO2020236947A1 (https=)

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CA3098574A1 (en) 2018-05-04 2019-11-07 Amgen Inc. Kras g12c inhibitors and methods of using the same
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EP3849535A4 (en) 2018-09-10 2022-06-29 Mirati Therapeutics, Inc. Combination therapies
JP7516029B2 (ja) 2018-11-16 2024-07-16 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
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WO2021061749A1 (en) 2019-09-24 2021-04-01 Mirati Therapeutics, Inc. Combination therapies
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EP4153588A1 (en) * 2020-05-20 2023-03-29 Teva Pharmaceuticals International GmbH Solid state forms of amg-510 and process for preparation thereof
EP4210833A4 (en) 2020-09-11 2024-09-11 Mirati Therapeutics, Inc. CRYSTALLINE FORMS OF A KRAS G12C INHIBITOR
EP4253376B1 (en) * 2020-11-26 2025-07-30 Shanghai Hansoh Biomedical Co., Ltd. Salt and crystal form of nitrogen-containing heterocyclic derivative, preparation method therefor and application thereof
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MX2023007918A (es) 2021-01-08 2023-07-13 Amgen Inc Uso de un inhibidor de kras g12c en el tratamiento de canceres.
US20220323446A1 (en) * 2021-03-17 2022-10-13 Amgen Inc. Sotorasib dosing regimen
JP2024518845A (ja) * 2021-05-19 2024-05-07 テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハー ソトラシブ及びその固体状態形態の調製のためのプロセス
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CN114605406B (zh) * 2021-09-18 2023-05-26 都创(上海)医药开发有限公司 Amg510化合物的晶型及其制备方法和用途
TW202340202A (zh) 2021-12-22 2023-10-16 美國加利福尼亞大學董事會 Gtp酶抑制劑及其用途
CN117327094B (zh) * 2022-07-01 2025-12-26 上海艾力斯医药科技股份有限公司 化合物或其药学上可接受的盐及其晶型
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