CA3205023A1 - Pyrido[2,3-d]imidazole derivatives and their use as inhibitors of itk for the teatment of skin disease - Google Patents

Pyrido[2,3-d]imidazole derivatives and their use as inhibitors of itk for the teatment of skin disease

Info

Publication number
CA3205023A1
CA3205023A1 CA3205023A CA3205023A CA3205023A1 CA 3205023 A1 CA3205023 A1 CA 3205023A1 CA 3205023 A CA3205023 A CA 3205023A CA 3205023 A CA3205023 A CA 3205023A CA 3205023 A1 CA3205023 A1 CA 3205023A1
Authority
CA
Canada
Prior art keywords
pharmaceutically acceptable
compound
acceptable salt
linked
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3205023A
Other languages
English (en)
French (fr)
Inventor
Scott William Bagley
Agustin Casimiro-Garcia
Jennifer Elizabeth Davoren
Rajiah Aldrin DENNY
Brian Stephen Gerstenberger
Katherine Lin Lee
Frank Eldridge Lovering
Mihir Dineshkumar PARIKH
Joseph Walter Strohbach
John Isidro Trujillo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CA3205023A1 publication Critical patent/CA3205023A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA3205023A 2020-12-15 2021-12-13 Pyrido[2,3-d]imidazole derivatives and their use as inhibitors of itk for the teatment of skin disease Pending CA3205023A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063125671P 2020-12-15 2020-12-15
US63/125,671 2020-12-15
PCT/IB2021/061645 WO2022130175A1 (en) 2020-12-15 2021-12-13 Pyrido[2,3-d]imidazole derivatives and their use as inhibitors of itk for the teatment of skin disease

Publications (1)

Publication Number Publication Date
CA3205023A1 true CA3205023A1 (en) 2022-06-23

Family

ID=78957649

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3205023A Pending CA3205023A1 (en) 2020-12-15 2021-12-13 Pyrido[2,3-d]imidazole derivatives and their use as inhibitors of itk for the teatment of skin disease

Country Status (5)

Country Link
US (1) US20240124439A1 (enExample)
EP (1) EP4263538A1 (enExample)
JP (1) JP2023552862A (enExample)
CA (1) CA3205023A1 (enExample)
WO (1) WO2022130175A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3205020A1 (en) * 2020-12-15 2022-06-23 Pfizer Inc. Benzimidazole derivatives and their use as inhibitors of itk for the treatment of skin disease
WO2024123175A1 (en) 2022-12-06 2024-06-13 Erasmus University Medical Center Rotterdam Compositions for treating immune checkpoint blockade therapy resistant cancers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2287971T3 (es) 1997-08-11 2007-12-16 Pfizer Products Inc. Dispersiones farmaceuticas solidas con biodisponibilidad incrementada.
BR0213562A (pt) * 2001-10-26 2004-08-31 Aventis Pharma Inc Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna
SE0202464D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Use of compounds
US8299070B2 (en) * 2009-11-25 2012-10-30 Japan Tobacco Inc. Indole compounds and pharmaceutical use thereof
WO2013026021A2 (en) * 2011-08-18 2013-02-21 Buck Institute For Research On Aging Trka as a target for inhibiting app cleavage and/or progression of alzheimer's disease
WO2013026201A1 (zh) * 2011-08-24 2013-02-28 厦门硅田系统工程有限公司 新型rfid标签微能量采集控制装置
WO2014041518A1 (en) * 2012-09-14 2014-03-20 Glenmark Pharmaceuticals S.A. Thienopyrrole derivatives as itk inhibitors
WO2016010108A1 (ja) * 2014-07-18 2016-01-21 塩野義製薬株式会社 含窒素複素環誘導体およびそれらを含有する医薬組成物

Also Published As

Publication number Publication date
US20240124439A1 (en) 2024-04-18
EP4263538A1 (en) 2023-10-25
JP2023552862A (ja) 2023-12-19
WO2022130175A1 (en) 2022-06-23

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