CA3198333A1 - Compositions d'anticorps pour traiter une infection par le virus corona - Google Patents
Compositions d'anticorps pour traiter une infection par le virus coronaInfo
- Publication number
- CA3198333A1 CA3198333A1 CA3198333A CA3198333A CA3198333A1 CA 3198333 A1 CA3198333 A1 CA 3198333A1 CA 3198333 A CA3198333 A CA 3198333A CA 3198333 A CA3198333 A CA 3198333A CA 3198333 A1 CA3198333 A1 CA 3198333A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- antibody
- vhh72
- heavy chain
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
- C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
La présente invention concerne des compositions d'anticorps ciblant de multiples épitopes sur le domaine de liaison au récepteur (RBD) de la protéine de spicule du virus Corona. Plus particulièrement, l'invention concerne des compositions comprenant des protéines de fusion d'anticorps qui comprennent un anticorps classique ciblant un épitope de protéine de spicule anti-SARS-CoV-2 et un domaine variable unique d'immunoglobuline (ISVD) fusionné audit anticorps, qui cible un épitope différent sur le domaine RBD. Plus particulièrement, l'invention concerne une composition d'anticorps comprenant une fusion entre l'anticorps spécifique de S309 anti-SARS-CoV-2 RBD (parent de VIR-7831/sotrovimab) et l'ISVD à base de VHH72, et son utilisation dans le traitement d'infections par le virus Corona, en particulier la Covid19.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2020502.7 | 2020-12-23 | ||
| GBGB2020502.7A GB202020502D0 (en) | 2020-12-23 | 2020-12-23 | Antibody composistion for treatment of corona virus infection |
| PCT/EP2021/087602 WO2022136685A1 (fr) | 2020-12-23 | 2021-12-23 | Compositions d'anticorps pour traiter une infection par le virus corona |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3198333A1 true CA3198333A1 (fr) | 2022-06-30 |
Family
ID=74221492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3198333A Pending CA3198333A1 (fr) | 2020-12-23 | 2021-12-23 | Compositions d'anticorps pour traiter une infection par le virus corona |
Country Status (3)
| Country | Link |
|---|---|
| CA (1) | CA3198333A1 (fr) |
| GB (1) | GB202020502D0 (fr) |
| WO (1) | WO2022136685A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114891097B (zh) * | 2021-09-16 | 2023-01-24 | 中国科学院微生物研究所 | 一株羊驼源纳米抗体及其应用 |
| GB202210573D0 (en) * | 2022-07-19 | 2022-08-31 | Autolus Ltd | Antibodies against SARS-CoV-2 and uses thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1621554T4 (da) | 1992-08-21 | 2012-12-17 | Univ Bruxelles | Immunoglobuliner blottet for lette kæder |
| DK0698097T3 (da) | 1993-04-29 | 2001-10-08 | Unilever Nv | Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde |
| FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
| EP0739981A1 (fr) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Fragments variables d'immunoglobulines-utilisation thérapeutique ou vétérinaire |
| ES2294799T3 (es) | 1996-06-27 | 2008-04-01 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Moleculas de anticuerpos que interactuan especificamente con el sitio activo o hendidura de una molecula diana. |
| WO1999037681A2 (fr) | 1998-01-26 | 1999-07-29 | Unilever Plc | Procede servant a preparer des fragments d'anticorps |
| AU3041100A (en) | 1999-01-05 | 2000-07-24 | Unilever Plc | Binding of antibody fragments to solid supports |
| DK1144616T4 (da) | 1999-01-19 | 2009-03-30 | Unilever Nv | Fremgangsmåde til fremstilling af antistoffragmenter |
| AP1447A (en) | 1999-04-22 | 2005-08-12 | Unilever Plc | Inhibition of viral infection using monovalent antigen-binding proteins. |
| US6479280B1 (en) | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
| ATE440111T1 (de) | 1999-11-29 | 2009-09-15 | Bac Ip B V | Immobilisierte antigenbindende moleküle aus einer domäne |
| EP1242460B1 (fr) | 1999-11-29 | 2006-10-18 | Unilever Plc | Immobilisation de proteines a l'aide d'un segment polypeptidique |
| DE60138333D1 (de) | 2000-03-14 | 2009-05-28 | Unilever Nv | Variabele Domänen der schweren Kette eines Antikörpers gegen menschliche Ernährungslipasen und deren Verwendungen |
| CA2380443C (fr) | 2000-05-26 | 2013-03-12 | Ginette Dubuc | Fragments d'anticorps de fixation d'antigenes monodomaines, derives d'anticorps de lamas |
| AU2002229639A1 (en) | 2000-12-13 | 2002-06-24 | De Haard, Johannes Joseph Wilhelmus | Camelidae antibody arrays |
| US7371849B2 (en) | 2001-09-13 | 2008-05-13 | Institute For Antibodies Co., Ltd. | Methods of constructing camel antibody libraries |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| AU2002351896A1 (en) | 2001-12-11 | 2003-06-23 | Ablynx N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| US20050037358A1 (en) | 2001-12-21 | 2005-02-17 | Serge Muyldermans | Method for cloning of variable domain sequences |
| JP2005517674A (ja) | 2002-01-03 | 2005-06-16 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー | 腫瘍の処置に有用な新規免疫コンジュゲート |
| CA2505326A1 (fr) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Procede d'administration de polypeptides therapeutiques et polypeptides associes |
| EP1558646A2 (fr) | 2002-11-08 | 2005-08-03 | Ablynx N.V. | Anticorps a domaine unique diriges contre un interferon gamma et leurs utilisations |
| EP2390270A1 (fr) | 2003-01-10 | 2011-11-30 | Ablynx N.V. | Polypeptides thérapeutiques, leurs homologues, leurs fragments et leur utilisation pour la modulation de l'agrégation de plaquettes |
| PT1687338E (pt) | 2003-11-07 | 2011-01-20 | Ablynx Nv | Anticorpos de domínio único vhh de camelídeos direccionados para o receptor do factor de crescimento epidérmico e suas utilizações |
| AU2005293752A1 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as Alzheimer's disease |
| CA2595682A1 (fr) | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Procede de generation de sequences a domaine variable d'anticorps a chaine lourde |
| MX2007014359A (es) | 2005-05-18 | 2008-02-06 | Ablynx Nv | Nanobodiestm (nanocuerpos) mejorados contra el factor alfa de necrosis del tumor. |
| SI2444424T1 (sl) | 2005-05-20 | 2018-10-30 | Ablynx N.V. | Izboljšana protitelesa (TM) za zdravljenje z agregacijo posredovanih motenj |
| EP2057191A1 (fr) | 2006-08-18 | 2009-05-13 | Ablynx N.V. | Séquences d'acides aminés dirigées contre l'il-6r et polypeptides les contenant utilisés pour le traitement de maladies et de troubles associés au signal médié par il-6 |
| AU2008219216A1 (en) | 2007-02-21 | 2008-08-28 | Ablynx N.V. | Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization |
| CA2687903C (fr) | 2007-05-24 | 2016-09-13 | Ablynx N.V. | Sequences d'acides amines dirigees contre rank-l et polypeptides comprenant ces dernieres, destines au traitement de maladies et affections osseuses |
| CN108653728B (zh) | 2011-06-23 | 2022-11-18 | 埃博灵克斯股份有限公司 | 用于预测、检测和减少涉及免疫球蛋白单可变结构域的测定法中的非特异性蛋白干扰的技术 |
| BR122018009619B1 (pt) | 2014-05-16 | 2024-01-02 | Ablynx N.V | Domínios variáveis de imunoglobulina aperfeiçoados |
| WO2021156490A2 (fr) | 2020-02-06 | 2021-08-12 | Vib Vzw | Liants du coronavirus |
| CN112094343B (zh) * | 2020-09-25 | 2022-05-13 | 中国科学技术大学 | 与SARS-CoV-2 RBD结合的羊驼源纳米抗体 |
-
2020
- 2020-12-23 GB GBGB2020502.7A patent/GB202020502D0/en not_active Ceased
-
2021
- 2021-12-23 WO PCT/EP2021/087602 patent/WO2022136685A1/fr active Application Filing
- 2021-12-23 CA CA3198333A patent/CA3198333A1/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB202020502D0 (en) | 2021-02-03 |
| WO2022136685A1 (fr) | 2022-06-30 |
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