CA3189302A1 - Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment - Google Patents

Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment

Info

Publication number
CA3189302A1
CA3189302A1 CA3189302A CA3189302A CA3189302A1 CA 3189302 A1 CA3189302 A1 CA 3189302A1 CA 3189302 A CA3189302 A CA 3189302A CA 3189302 A CA3189302 A CA 3189302A CA 3189302 A1 CA3189302 A1 CA 3189302A1
Authority
CA
Canada
Prior art keywords
alkyl
polymorph
solvate
hydrate
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3189302A
Other languages
English (en)
French (fr)
Inventor
Michela Gallagher
Sharon Rosenzweig-Lipson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agenebio Inc
Original Assignee
Agenebio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agenebio Inc filed Critical Agenebio Inc
Publication of CA3189302A1 publication Critical patent/CA3189302A1/en
Pending legal-status Critical Current

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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3189302A 2020-07-10 2021-07-09 Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment Pending CA3189302A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063050730P 2020-07-10 2020-07-10
US63/050,730 2020-07-10
PCT/US2021/041184 WO2022011318A1 (en) 2020-07-10 2021-07-09 Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment

Publications (1)

Publication Number Publication Date
CA3189302A1 true CA3189302A1 (en) 2022-01-13

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CA3189302A Pending CA3189302A1 (en) 2020-07-10 2021-07-09 Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment

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US (2) US20230270753A1 (https=)
EP (1) EP4178582A4 (https=)
JP (1) JP2023534189A (https=)
CN (1) CN116075302A (https=)
AU (1) AU2021304356A1 (https=)
BR (1) BR112023000423A2 (https=)
CA (1) CA3189302A1 (https=)
IL (1) IL299754A (https=)
MX (1) MX2023000405A (https=)
WO (1) WO2022011318A1 (https=)

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Publication number Priority date Publication date Assignee Title
JP7737721B2 (ja) * 2019-12-19 2025-09-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
EP4504176A1 (en) * 2022-04-01 2025-02-12 Agenebio, Inc. Methods for preventing or slowing the progression of cognitive decline or impairment in subjects displaying normal cognitive performance
CN120584115A (zh) 2022-08-19 2025-09-02 艾吉因生物股份有限公司 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法

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Publication number Priority date Publication date Assignee Title
ES2865504T3 (es) * 2008-10-16 2021-10-15 Univ Johns Hopkins Procedimientos y composiciones para la mejora de la función cognitiva
AU2011215870B2 (en) * 2010-02-09 2016-01-28 The Johns Hopkins University Methods and compositions for improving cognitive function
US20140206667A1 (en) * 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
WO2014153180A1 (en) * 2013-03-14 2014-09-25 Michela Gallagher Methods and compositions for improving cognitive function
NZ760341A (en) * 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN112601749B (zh) * 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法

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BR112023000423A2 (pt) 2023-03-14
AU2021304356A1 (en) 2023-02-23
JP2023534189A (ja) 2023-08-08
IL299754A (en) 2023-03-01
MX2023000405A (es) 2023-05-10
EP4178582A4 (en) 2024-07-10
CN116075302A (zh) 2023-05-05
WO2022011318A1 (en) 2022-01-13
US20220062296A1 (en) 2022-03-03
EP4178582A1 (en) 2023-05-17
US20230270753A1 (en) 2023-08-31

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