BR112023000423A2 - Combinações de agonistas gabaa alfa 5 e inibidores de sv2a e métodos de uso no tratamento de comprometimento cognitivo - Google Patents

Combinações de agonistas gabaa alfa 5 e inibidores de sv2a e métodos de uso no tratamento de comprometimento cognitivo

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Publication number
BR112023000423A2
BR112023000423A2 BR112023000423A BR112023000423A BR112023000423A2 BR 112023000423 A2 BR112023000423 A2 BR 112023000423A2 BR 112023000423 A BR112023000423 A BR 112023000423A BR 112023000423 A BR112023000423 A BR 112023000423A BR 112023000423 A2 BR112023000423 A2 BR 112023000423A2
Authority
BR
Brazil
Prior art keywords
cognitive impairment
treatment
combinations
methods
agonists
Prior art date
Application number
BR112023000423A
Other languages
English (en)
Portuguese (pt)
Inventor
Gallagher Michela
Rosenzweig-Lipson Sharon
Original Assignee
Agenebio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agenebio Inc filed Critical Agenebio Inc
Publication of BR112023000423A2 publication Critical patent/BR112023000423A2/pt

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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112023000423A 2020-07-10 2021-07-09 Combinações de agonistas gabaa alfa 5 e inibidores de sv2a e métodos de uso no tratamento de comprometimento cognitivo BR112023000423A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063050730P 2020-07-10 2020-07-10
PCT/US2021/041184 WO2022011318A1 (en) 2020-07-10 2021-07-09 Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment

Publications (1)

Publication Number Publication Date
BR112023000423A2 true BR112023000423A2 (pt) 2023-03-14

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BR112023000423A BR112023000423A2 (pt) 2020-07-10 2021-07-09 Combinações de agonistas gabaa alfa 5 e inibidores de sv2a e métodos de uso no tratamento de comprometimento cognitivo

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US (2) US20230270753A1 (https=)
EP (1) EP4178582A4 (https=)
JP (1) JP2023534189A (https=)
CN (1) CN116075302A (https=)
AU (1) AU2021304356A1 (https=)
BR (1) BR112023000423A2 (https=)
CA (1) CA3189302A1 (https=)
IL (1) IL299754A (https=)
MX (1) MX2023000405A (https=)
WO (1) WO2022011318A1 (https=)

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JP7737721B2 (ja) * 2019-12-19 2025-09-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
EP4504176A1 (en) * 2022-04-01 2025-02-12 Agenebio, Inc. Methods for preventing or slowing the progression of cognitive decline or impairment in subjects displaying normal cognitive performance
CN120584115A (zh) 2022-08-19 2025-09-02 艾吉因生物股份有限公司 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法

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ES2865504T3 (es) * 2008-10-16 2021-10-15 Univ Johns Hopkins Procedimientos y composiciones para la mejora de la función cognitiva
AU2011215870B2 (en) * 2010-02-09 2016-01-28 The Johns Hopkins University Methods and compositions for improving cognitive function
US20140206667A1 (en) * 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
WO2014153180A1 (en) * 2013-03-14 2014-09-25 Michela Gallagher Methods and compositions for improving cognitive function
NZ760341A (en) * 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN112601749B (zh) * 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法

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AU2021304356A1 (en) 2023-02-23
JP2023534189A (ja) 2023-08-08
IL299754A (en) 2023-03-01
MX2023000405A (es) 2023-05-10
CA3189302A1 (en) 2022-01-13
EP4178582A4 (en) 2024-07-10
CN116075302A (zh) 2023-05-05
WO2022011318A1 (en) 2022-01-13
US20220062296A1 (en) 2022-03-03
EP4178582A1 (en) 2023-05-17
US20230270753A1 (en) 2023-08-31

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