CN116075302A - GABAAα5激动剂和SV2A抑制剂的组合以及在认知损害的治疗中的使用方法 - Google Patents

GABAAα5激动剂和SV2A抑制剂的组合以及在认知损害的治疗中的使用方法 Download PDF

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Publication number
CN116075302A
CN116075302A CN202180062022.9A CN202180062022A CN116075302A CN 116075302 A CN116075302 A CN 116075302A CN 202180062022 A CN202180062022 A CN 202180062022A CN 116075302 A CN116075302 A CN 116075302A
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alkyl
compound
polymorph
hydrate
solvate
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M·加拉格尔
S·罗森茨威格-利普森
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Agenebio Inc
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CN202180062022.9A 2020-07-10 2021-07-09 GABAAα5激动剂和SV2A抑制剂的组合以及在认知损害的治疗中的使用方法 Pending CN116075302A (zh)

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US202063050730P 2020-07-10 2020-07-10
US63/050,730 2020-07-10
PCT/US2021/041184 WO2022011318A1 (en) 2020-07-10 2021-07-09 Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment

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EP (1) EP4178582A4 (https=)
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AU (1) AU2021304356A1 (https=)
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JP7737721B2 (ja) * 2019-12-19 2025-09-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
EP4504176A1 (en) * 2022-04-01 2025-02-12 Agenebio, Inc. Methods for preventing or slowing the progression of cognitive decline or impairment in subjects displaying normal cognitive performance
CN120584115A (zh) 2022-08-19 2025-09-02 艾吉因生物股份有限公司 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法

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ES2865504T3 (es) * 2008-10-16 2021-10-15 Univ Johns Hopkins Procedimientos y composiciones para la mejora de la función cognitiva
AU2011215870B2 (en) * 2010-02-09 2016-01-28 The Johns Hopkins University Methods and compositions for improving cognitive function
US20140206667A1 (en) * 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
WO2014153180A1 (en) * 2013-03-14 2014-09-25 Michela Gallagher Methods and compositions for improving cognitive function
NZ760341A (en) * 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN112601749B (zh) * 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法

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