CA3185370A1 - Anti-il13r.alpha.2 antibodies - Google Patents
Anti-il13r.alpha.2 antibodiesInfo
- Publication number
- CA3185370A1 CA3185370A1 CA3185370A CA3185370A CA3185370A1 CA 3185370 A1 CA3185370 A1 CA 3185370A1 CA 3185370 A CA3185370 A CA 3185370A CA 3185370 A CA3185370 A CA 3185370A CA 3185370 A1 CA3185370 A1 CA 3185370A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- antibody
- amino acid
- acid sequence
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2011993.9A GB202011993D0 (en) | 2020-07-31 | 2020-07-31 | ANTI-IL 13Ra2 antibodies |
| GB2011993.9 | 2020-07-31 | ||
| PCT/EP2021/071389 WO2022023522A1 (en) | 2020-07-31 | 2021-07-30 | ANTI-IL13Rα2 ANTIBODIES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3185370A1 true CA3185370A1 (en) | 2022-02-03 |
Family
ID=72425115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3185370A Pending CA3185370A1 (en) | 2020-07-31 | 2021-07-30 | Anti-il13r.alpha.2 antibodies |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11976122B2 (https=) |
| EP (1) | EP4188955A1 (https=) |
| JP (1) | JP2023536155A (https=) |
| KR (1) | KR20230042724A (https=) |
| CN (1) | CN116194481A (https=) |
| AR (1) | AR123091A1 (https=) |
| AU (1) | AU2021316626A1 (https=) |
| CA (1) | CA3185370A1 (https=) |
| GB (1) | GB202011993D0 (https=) |
| IL (1) | IL300142A (https=) |
| MX (1) | MX2022016494A (https=) |
| TW (1) | TW202221032A (https=) |
| WO (1) | WO2022023522A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023088963A1 (en) * | 2021-11-19 | 2023-05-25 | Adc Therapeutics Sa | Anti-il-13ralpha2 conjugates |
| WO2025019776A2 (en) * | 2023-07-20 | 2025-01-23 | Exelixis, Inc. | Interleukin-13 receptor subunit alpha-2 antibody-drug conjugates and uses thereof |
| WO2025025597A1 (zh) | 2023-08-03 | 2025-02-06 | 森妙生物科技(西安)有限公司 | 一种抗体或其抗原结合片段及其应用 |
Family Cites Families (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US6428788B1 (en) | 1995-03-15 | 2002-08-06 | Penn State University | Compositions and methods for specifically targeting tumors |
| JP2002509158A (ja) | 1998-01-15 | 2002-03-26 | センター・フォー・モレキュラー・メディシン・アンド・イムノロジー | アーム付きリガンドの送達向上のための抗体と受容体ターゲティング部分 |
| WO2001058479A1 (en) | 2000-02-08 | 2001-08-16 | The Penn State Research Foundation | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
| US7541040B2 (en) | 2001-12-04 | 2009-06-02 | The United States Of America As Represented By The Department Of Health And Human Serivces | Chimeric molecule for the treatment of th2-like cytokine mediated disorders |
| US9770517B2 (en) | 2002-03-01 | 2017-09-26 | Immunomedics, Inc. | Anti-Trop-2 antibody-drug conjugates and uses thereof |
| WO2003092717A1 (en) | 2002-03-22 | 2003-11-13 | The Penn State Research Foundation | Cancer immunotherapy |
| ES2365210T3 (es) | 2002-06-14 | 2011-09-26 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health | Procedimientos de tratamiento y prevención de colitis en la que se implican la il-13 y los linfocitos t citolíticos naturales. |
| CN1878568A (zh) | 2003-11-05 | 2006-12-13 | 盘林京有限公司 | Cdim结合抗体的增强的b细胞细胞毒性 |
| EP1720908A2 (en) | 2004-02-17 | 2006-11-15 | Absalus, Inc. | Super-humanized antibodies against respiratory syncytial virus |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| AU2006210724A1 (en) | 2005-02-03 | 2006-08-10 | Antitope Limited | Human antibodies and proteins |
| NZ612578A (en) | 2005-08-19 | 2014-11-28 | Abbvie Inc | Dual variable domain immunoglobin and uses thereof |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| EP2500355A3 (en) | 2005-08-19 | 2012-10-24 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| SI1934174T1 (sl) | 2005-10-07 | 2011-08-31 | Exelixis Inc | Inhibitorji MEK in postopki za njihovo uporabo |
| WO2007089871A2 (en) | 2006-02-01 | 2007-08-09 | The Johns Hopkins University | Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders |
| CL2008001334A1 (es) | 2007-05-08 | 2008-09-22 | Genentech Inc | Anticuerpo anti-muc16 disenado con cisteina; conjugado que lo comprende; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso para tratar el cancer. |
| PT2592148T (pt) | 2007-10-12 | 2018-11-12 | Hoffmann La Roche | Expressão proteica de múltiplos ácidos nucleicos |
| NZ584514A (en) | 2007-10-19 | 2012-07-27 | Genentech Inc | Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates |
| US20160095939A1 (en) | 2014-10-07 | 2016-04-07 | Immunomedics, Inc. | Neoadjuvant use of antibody-drug conjugates |
| ES3000111T3 (en) | 2009-02-13 | 2025-02-27 | Immunomedics Inc | Intermediates for preparing conjugates with an intracellularly-cleavable linkage |
| CN101585880B (zh) | 2009-05-15 | 2011-10-26 | 中国人民解放军第四军医大学 | 一种抗人IL-13Rα2单克隆抗体的重链和轻链的可变区 |
| UY33826A (es) | 2010-12-22 | 2012-07-31 | Abbott Lab | Proteínas de unión con dominios trivariables y sus usos |
| US20120201746A1 (en) | 2010-12-22 | 2012-08-09 | Abbott Laboratories | Half immunoglobulin binding proteins and uses thereof |
| EP2828664B1 (en) | 2012-03-19 | 2018-09-26 | Stemline Therapeutics Inc. | Methods for treating and monitoring the status of cancer |
| RS57694B1 (sr) | 2012-10-12 | 2018-11-30 | Adc Therapeutics Sa | Pirolobenzodiazepin - anti-psma konjugati antitela |
| HRP20182129T1 (hr) | 2012-10-12 | 2019-02-08 | Adc Therapeutics Sa | Konjugati protutijelo - pirolobenzodiazepin |
| WO2014057118A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sarl | Pyrrolobenzodiazepine-anti-cd22 antibody conjugates |
| ES2680153T3 (es) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas |
| EP2906296B1 (en) | 2012-10-12 | 2018-03-21 | ADC Therapeutics SA | Pyrrolobenzodiazepine-antibody conjugates |
| EP2906297B1 (en) | 2012-10-12 | 2017-12-06 | ADC Therapeutics SA | Pyrrolobenzodiazepine-antibody conjugates |
| SI2906252T1 (sl) | 2012-10-12 | 2017-10-30 | Adc Therapeutics Sa | Pirolobenzodiazepin-anti-HER2 protitelesni konjugati |
| JP6392765B2 (ja) | 2012-10-12 | 2018-09-19 | エイディーシー・セラピューティクス・エス・アーＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａ | ピロロベンゾジアゼピン−抗体結合体 |
| KR101763499B1 (ko) | 2012-11-07 | 2017-07-31 | 화이자 인코포레이티드 | 항-il-13 수용체 알파 2 항체 및 항체-약물 접합체 |
| WO2015012904A2 (en) | 2012-12-13 | 2015-01-29 | Immunomedics, Inc. | Antibody-sn-38 immunoconjugates with a cl2a linker |
| US10137196B2 (en) | 2012-12-13 | 2018-11-27 | Immunomedics, Inc. | Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity |
| JP2016513098A (ja) | 2013-02-07 | 2016-05-12 | イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． | 癌の標的治療用抗体と抱合した極めて強力なプロドラック形態の２−ピロリノドキソルビシン（ｐ２ｐｄｏｘ） |
| EP2970492B1 (en) | 2013-03-15 | 2019-05-08 | Wake Forest University Health Sciences | Antibodies against human and canine il-13ra2 |
| WO2014163684A1 (en) | 2013-04-03 | 2014-10-09 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| TWI641620B (zh) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | 抗－ｐｒｌｒ抗體及其用途 |
| WO2015052534A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| WO2015052535A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| US20160256561A1 (en) | 2013-10-11 | 2016-09-08 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| EP3054983B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| WO2015070210A1 (en) | 2013-11-11 | 2015-05-14 | Wake Forest University Health Sciences | Epha3 and multi-valent targeting of tumors |
| JP6447933B2 (ja) | 2014-02-21 | 2019-01-09 | アイビーシー ファーマスーティカルズ，インコーポレイテッド | Ｔｒｏｐ−２発現細胞に対する免疫応答を誘発することによる疾患治療 |
| GB201406767D0 (en) | 2014-04-15 | 2014-05-28 | Cancer Rec Tech Ltd | Humanized anti-Tn-MUC1 antibodies anf their conjugates |
| BR112017005631A2 (pt) | 2014-09-19 | 2018-06-26 | City Of Hope | células t com receptor de antígeno coestimulador quimérico direcionadas à il13ra2 |
| CN107148285B (zh) | 2014-11-25 | 2022-01-04 | Adc治疗股份有限公司 | 吡咯并苯并二氮杂䓬-抗体缀合物 |
| CN107683289B (zh) | 2015-01-26 | 2021-08-06 | 芝加哥大学 | IL13Rα2结合剂和其在癌症治疗中的用途 |
| WO2016123143A1 (en) | 2015-01-26 | 2016-08-04 | The University Of Chicago | CAR T-CELLS RECOGNIZING CANCER-SPECIFIC IL 13Rα2 |
| GB201506389D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201506409D0 (en) | 2015-04-15 | 2015-05-27 | Williams David G And Berkel Patricius H C Van And Howard Philip W | Humanized anti-axl antibodies and their conjugates |
| GB201506388D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Cancer Res Technology Ltd And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201506399D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201506407D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201506394D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201506405D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201506393D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201507827D0 (en) | 2015-05-07 | 2015-06-17 | Adc Therapeutics Sarl | Diagnostic test |
| AU2016274989A1 (en) | 2015-06-12 | 2017-11-02 | Immunomedics, Inc. | Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs |
| JP6980980B2 (ja) | 2015-06-25 | 2021-12-15 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | 抗ｈｌａ‐ｄｒまたは抗ｔｒｏｐ‐２抗体と微小管阻害剤、ｐａｒｐ阻害剤、ブルトンキナーゼ阻害剤またはホスホイノシチド３‐キナーゼ阻害剤との併用は癌の治療効果を有意に改善する |
| WO2017011342A1 (en) | 2015-07-10 | 2017-01-19 | Abbvie Inc. | Igm-or-ige-modified binding proteins and uses thereof |
| GB201513607D0 (en) | 2015-07-31 | 2015-09-16 | Feingold Jay M | Pyrrolobenzodiazepine-antibody conjugates |
| PE20181363A1 (es) | 2015-09-23 | 2018-08-27 | Genentech Inc | Variantes optimizadas de anticuerpos anti-vegf |
| US10508143B1 (en) | 2015-10-30 | 2019-12-17 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
| CN108472365A (zh) | 2015-10-30 | 2018-08-31 | 艾丽塔生物治疗剂公司 | 用于肿瘤转导的组合物和方法 |
| GB201602363D0 (en) | 2016-02-10 | 2016-03-23 | Adc Therapeutics Sa And Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| CN108601841A (zh) | 2016-02-10 | 2018-09-28 | 免疫医疗公司 | Abcg2抑制剂与sacituzumab govitecan(immu-132)的组合克服表达trop-2的癌中对sn-38的抗性 |
| CN109195992A (zh) | 2016-04-29 | 2019-01-11 | 本康生物制药（深圳）有限公司 | 多特异性结合偶联物、相关的药物组合物及应用 |
| WO2017210058A1 (en) | 2016-06-01 | 2017-12-07 | Ibc Pharmaceuticals, Inc. | Combination therapy with t-cell redirecting bispecific antibodies and checkpoint inhibitors |
| EP3548055A4 (en) | 2016-12-02 | 2020-08-19 | University of Southern California | SYNTHETIC IMMUNE RECEPTORS AND THEIR PROCESSES FOR USE |
| CA3050085A1 (en) | 2017-01-20 | 2018-07-26 | Juno Therapeutics Gmbh | Cell surface conjugates and related cell compositions and methods |
| HUE056289T2 (hu) | 2017-02-08 | 2022-02-28 | Adc Therapeutics Sa | Pirrolobenzodiazepin-antitest konjugátumok |
| RS61795B1 (sr) | 2017-02-08 | 2021-06-30 | Adc Therapeutics Sa | Konjugati pirolobenzodiazepin antitela |
| CN108456250B (zh) * | 2017-02-17 | 2025-11-28 | 恺兴生命科技(上海)有限公司 | 靶向il-13ra2的抗体及其应用 |
| US20200306375A1 (en) | 2017-02-22 | 2020-10-01 | Aleta Biotherapeutics Inc. | Compositions and methods for tumor transduction |
| CA3054885A1 (en) * | 2017-03-03 | 2018-09-07 | Rinat Neuroscience Corp. | Anti-gitr antibodies and methods of use thereof |
| AR111190A1 (es) | 2017-03-22 | 2019-06-12 | Genentech Inc | Composiciones en hidrogel de prodrogas entrecruzadas de ácido hialurónico y métodos relacionados |
| MA49279A (fr) | 2017-03-22 | 2020-02-05 | Hoffmann La Roche | Compositions d'anticorps optimisées pour le traitement de troubles oculaires |
| US10799597B2 (en) | 2017-04-03 | 2020-10-13 | Immunomedics, Inc. | Subcutaneous administration of antibody-drug conjugates for cancer therapy |
| KR20210122319A (ko) | 2017-04-06 | 2021-10-08 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 비스-링키지를 사용한 세포독성 약물의 접합 |
| MX2019012017A (es) | 2017-04-07 | 2020-02-12 | Juno Therapeutics Inc | Celulas modificadas que expresan antigeno de membrana especifico de prostata (psma) o una forma modificada del mismo y metodos relacionados. |
| SG11201909160WA (en) | 2017-04-11 | 2019-10-30 | Inhibrx Inc | Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same |
| EP3612839A1 (en) | 2017-04-20 | 2020-02-26 | ADC Therapeutics SA | Combination therapy |
| WO2018193102A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
| EP3612235A1 (en) | 2017-04-20 | 2020-02-26 | ADC Therapeutics SA | Combination therapy with an anti-psma antibody-drug conjugate |
| EP3612236A1 (en) | 2017-04-20 | 2020-02-26 | ADC Therapeutics SA | Combination therapy with an anti-cd25 antibody-drug conjugate |
| KR20200007905A (ko) | 2017-05-18 | 2020-01-22 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| WO2018217227A1 (en) | 2017-05-24 | 2018-11-29 | Immunomedics, Inc. | Novel anti-pd-1 checkpoint inhibitor antibodies that block binding of pd-l1 to pd-1 |
| BR112019026498A2 (pt) | 2017-06-14 | 2020-07-14 | Adc Therapeutics Sa | regimes de dosagem para a administração de um adc anti-cd25 |
| CA3064804A1 (en) | 2017-06-14 | 2018-12-20 | Adc Therapeutics Sa | Dosage regimes for the administration of an anti-cd19 adc |
| EP3480212B1 (en) * | 2017-11-03 | 2023-09-27 | Consejo Superior De Investigaciones Científicas | Il13ralpha2 peptide and its uses |
| MX2020004691A (es) | 2017-11-07 | 2020-08-20 | Regeneron Pharma | Enlazadores hidrofilicos para conjugados anticuerpo-farmaco. |
| JP7404252B2 (ja) | 2017-11-08 | 2023-12-25 | ヤフェイ シャンハイ バイオロジー メディスン サイエンス アンド テクノロジー カンパニー リミテッド | 生体分子のコンジュゲートおよびその使用 |
| JP7542438B2 (ja) | 2017-11-21 | 2024-08-30 | ノバルティス アーゲー | 腫瘍関連抗原に対する三重特異性結合分子及びその使用 |
| EP3621652A4 (en) | 2017-12-31 | 2021-01-13 | Hangzhou DAC Biotech Co, Ltd | CONJUGATE OF ANALOGUE OF TUBULYSIN WITH BRANCHED LINKS |
| GB201802172D0 (en) | 2018-02-09 | 2018-03-28 | Adc Therapeutics S A | Treatment of Car T-Cell Toxicity |
| GB201802312D0 (en) | 2018-02-13 | 2018-03-28 | Vib Vzw | Melanoma disease stratification |
| EP3781176A4 (en) | 2018-04-09 | 2022-05-25 | The Trustees of the University of Pennsylvania | METHODS AND COMPOSITIONS USING A VIRAL VECTOR FOR THE EXPRESSION OF A TRANSGENE AND AN EFFECTOR |
| KR20260046525A (ko) | 2018-04-11 | 2026-04-07 | 인히브릭스 바이오사이언스, 인크. | 제한된 cd3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 관련된 방법 및 용도 |
| CA3099308A1 (en) | 2018-05-21 | 2019-11-28 | Compass Therapeutics Llc | Compositions and methods for enhancing the killing of target cells by nk cells |
| CA3098103A1 (en) | 2018-05-23 | 2019-11-28 | Adc Therapeutics Sa | Molecular adjuvant |
| EA202190189A1 (ru) | 2018-07-05 | 2021-04-16 | Ханчжоу Дэк Биотек Ко., Лтд | Сшитое производное димера пирролобензодиазепина (pbd) и его конъюгаты |
| GB201811364D0 (en) | 2018-07-11 | 2018-08-29 | Adc Therapeutics Sa | Combination therapy |
| EP3827019A1 (en) | 2018-07-24 | 2021-06-02 | Inhibrx, Inc. | Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same |
| BR112021001338A2 (pt) * | 2018-07-26 | 2021-05-04 | TCR2 Therapeutics Inc. | composições e métodos para reprogramação de tcr usando proteínas de fusão específicas para o alvo |
| ES3037206T3 (en) | 2018-08-31 | 2025-09-30 | Adc Therapeutics Sa | Combination therapy |
| IL282182B2 (en) | 2018-10-12 | 2025-09-01 | Hangzhou Dac Biotech Co Ltd | Cytotoxic drug conjugates with a bis linkage |
| WO2020109251A1 (en) | 2018-11-29 | 2020-06-04 | Adc Therapeutics Sa | Dosage regime |
| US20220062352A1 (en) | 2018-12-03 | 2022-03-03 | Demata Therapeutics, LLC | Compositions for the treatment of conditions |
| WO2020052692A2 (en) | 2018-12-04 | 2020-03-19 | Novartis Ag | Binding molecules against cd3 and uses thereof |
| WO2020127573A1 (en) | 2018-12-19 | 2020-06-25 | Adc Therapeutics Sa | Pyrrolobenzodiazepine resistance |
| CA3128264A1 (en) | 2019-01-31 | 2020-08-06 | Hangzhou Dac Biotech Co., Ltd | A conjugate of an amanita toxin with branched linkers |
| AU2020219736A1 (en) | 2019-02-04 | 2021-09-30 | Xenetic Biosciences, Inc. | Methods of using glycopolysialylated therapeutic proteins |
| WO2020168106A1 (en) | 2019-02-13 | 2020-08-20 | Notable Labs, Inc. | Combinations of agonists of protein kinase c with steroids or retinoic acids for the treatment of cancer |
| US20220362381A1 (en) | 2019-02-21 | 2022-11-17 | Bambu Vault Llc | Remotely triggered therapy |
| US20220362295A1 (en) | 2019-04-22 | 2022-11-17 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| AU2020267131A1 (en) | 2019-05-02 | 2021-11-25 | Revitope Limited | TEAC and ATTAC immunooncology compositions and methods |
| US12037378B2 (en) | 2019-05-21 | 2024-07-16 | Novartis Ag | Variant CD58 domains and uses thereof |
-
2020
- 2020-07-31 GB GBGB2011993.9A patent/GB202011993D0/en not_active Ceased
-
2021
- 2021-07-30 MX MX2022016494A patent/MX2022016494A/es unknown
- 2021-07-30 WO PCT/EP2021/071389 patent/WO2022023522A1/en not_active Ceased
- 2021-07-30 CN CN202180058680.0A patent/CN116194481A/zh active Pending
- 2021-07-30 US US17/389,582 patent/US11976122B2/en active Active
- 2021-07-30 IL IL300142A patent/IL300142A/en unknown
- 2021-07-30 TW TW110128219A patent/TW202221032A/zh unknown
- 2021-07-30 JP JP2023506175A patent/JP2023536155A/ja active Pending
- 2021-07-30 AU AU2021316626A patent/AU2021316626A1/en active Pending
- 2021-07-30 KR KR1020237006291A patent/KR20230042724A/ko active Pending
- 2021-07-30 EP EP21762352.9A patent/EP4188955A1/en active Pending
- 2021-07-30 AR ARP210102122A patent/AR123091A1/es unknown
- 2021-07-30 CA CA3185370A patent/CA3185370A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB202011993D0 (en) | 2020-09-16 |
| US11976122B2 (en) | 2024-05-07 |
| MX2022016494A (es) | 2023-01-30 |
| IL300142A (en) | 2023-03-01 |
| JP2023536155A (ja) | 2023-08-23 |
| AR123091A1 (es) | 2022-10-26 |
| AU2021316626A1 (en) | 2023-02-02 |
| CN116194481A (zh) | 2023-05-30 |
| US20220033508A1 (en) | 2022-02-03 |
| TW202221032A (zh) | 2022-06-01 |
| KR20230042724A (ko) | 2023-03-29 |
| WO2022023522A1 (en) | 2022-02-03 |
| EP4188955A1 (en) | 2023-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20230053603A1 (en) | Pyrrolobenzodiazepine-antibody conjugates | |
| CA3047683C (en) | Pyrrolobenzodiazepine-antibody conjugates | |
| AU2015352545B2 (en) | Pyrrolobenzodiazepine-antibody conjugates | |
| US20200405873A1 (en) | Pyrrolobenzodiazepine-antibody conjugates | |
| KR20170137116A (ko) | 부위-특이적 항체-약물 접합체 | |
| US11976122B2 (en) | Anti-IL13Rα2 antibodies | |
| KR20170137115A (ko) | 부위-특이적 항체-약물 접합체 | |
| WO2016166296A2 (en) | Humanized anti-axl antibodies | |
| KR20170137786A (ko) | 부위-특이적 항체-약물 접합체 | |
| AU2019332979B2 (en) | Combination therapy | |
| CN112367999A (zh) | 组合疗法 | |
| CN114375204B (zh) | 吡咯并苯并二氮杂䓬-抗体缀合物 | |
| EA047081B1 (ru) | АНТИТЕЛА К IL13Rα2 | |
| HK40056993A (en) | Pyrrolobenzodiazepine-antibody conjugates | |
| HK40101576A (zh) | 使用抗体药物缀合物的组合疗法 | |
| HK40012498A (en) | Pyrrolobenzodiazepine-antibody conjugates | |
| HK40012498B (en) | Pyrrolobenzodiazepine-antibody conjugates | |
| HK40012528A (en) | Pyrrolobenzodiazepine-antibody conjugates | |
| HK40012528B (en) | Pyrrolobenzodiazepine-antibody conjugates |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 3RD ANNIV.) - STANDARD Year of fee payment: 3 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST TO REGISTER A DOCUMENT RECEIVED Effective date: 20241125 Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20241125 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 4TH ANNIV.) - STANDARD Year of fee payment: 4 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250703 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250703 |