CA3177027A1 - Constructions modifiees de polypeptide de liaison a un antigene et leurs utilisations - Google Patents
Constructions modifiees de polypeptide de liaison a un antigene et leurs utilisationsInfo
- Publication number
- CA3177027A1 CA3177027A1 CA3177027A CA3177027A CA3177027A1 CA 3177027 A1 CA3177027 A1 CA 3177027A1 CA 3177027 A CA3177027 A CA 3177027A CA 3177027 A CA3177027 A CA 3177027A CA 3177027 A1 CA3177027 A1 CA 3177027A1
- Authority
- CA
- Canada
- Prior art keywords
- amino acid
- acid modifications
- construct
- heterodimer
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/522—CH1 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462003663P | 2014-05-28 | 2014-05-28 | |
| US62/003,663 | 2014-05-28 | ||
| US201562154055P | 2015-04-28 | 2015-04-28 | |
| US62/154,055 | 2015-04-28 | ||
| CA2946503A CA2946503C (fr) | 2014-05-28 | 2015-05-29 | Constructions modifiees de polypeptide de liaison a un antigene et leurs utilisations |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2946503A Division CA2946503C (fr) | 2014-05-28 | 2015-05-29 | Constructions modifiees de polypeptide de liaison a un antigene et leurs utilisations |
Publications (1)
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|---|---|
| CA3177027A1 true CA3177027A1 (fr) | 2015-12-03 |
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| CA2946503A Active CA2946503C (fr) | 2014-05-28 | 2015-05-29 | Constructions modifiees de polypeptide de liaison a un antigene et leurs utilisations |
| CA3177027A Pending CA3177027A1 (fr) | 2014-05-28 | 2015-05-29 | Constructions modifiees de polypeptide de liaison a un antigene et leurs utilisations |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2946503A Active CA2946503C (fr) | 2014-05-28 | 2015-05-29 | Constructions modifiees de polypeptide de liaison a un antigene et leurs utilisations |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11306156B2 (fr) |
| EP (2) | EP4026850A1 (fr) |
| KR (1) | KR102493430B1 (fr) |
| AU (3) | AU2015265457B2 (fr) |
| BR (1) | BR112016027888A2 (fr) |
| CA (2) | CA2946503C (fr) |
| DK (1) | DK3107938T3 (fr) |
| EA (1) | EA201692476A1 (fr) |
| HK (1) | HK1231490A1 (fr) |
| MX (2) | MX2016015459A (fr) |
| RU (1) | RU2729467C2 (fr) |
| WO (1) | WO2015181805A1 (fr) |
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| US9562109B2 (en) | 2010-11-05 | 2017-02-07 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
| MY166429A (en) | 2010-11-17 | 2018-06-26 | Chugai Pharmaceutical Co Ltd | Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii |
| CA2854233C (fr) | 2011-11-04 | 2020-05-12 | Zymeworks Inc. | Structure d'anticorps heterodimerique stable comprenant des mutations dans le domaine fc |
| WO2014004586A1 (fr) | 2012-06-25 | 2014-01-03 | Zymeworks Inc. | Processus et procédés pour la fabrication efficace d'anticorps asymétriques hautement purs dans des cellules de mammifère |
| AU2013326974B2 (en) | 2012-10-03 | 2019-01-03 | Zymeworks Bc Inc. | Methods of quantitating heavy and light chain polypeptide pairs |
| US9914785B2 (en) * | 2012-11-28 | 2018-03-13 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
| KR102264570B1 (ko) | 2012-11-28 | 2021-06-14 | 자임워크스 인코포레이티드 | 가공된 면역글로불린 중쇄-경쇄 쌍 및 이들의 용도 |
| MX2016015459A (es) * | 2014-05-28 | 2017-12-14 | Zymeworks Inc | Construcciones polipeptidicas de union al antigeno modificadas y usos de estas. |
| AU2015329965A1 (en) * | 2014-10-09 | 2017-04-27 | Engmab Sàrl | Bispecific antibodies against CD3epsilon and ROR1 |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| JP6952605B2 (ja) | 2015-04-24 | 2021-10-20 | ジェネンテック， インコーポレイテッド | 多特異性抗原結合タンパク質 |
| KR102669686B1 (ko) * | 2015-04-28 | 2024-05-29 | 자임워크스 비씨 인코포레이티드 | 변형된 항원 결합 폴리펩티드 작제물 및 이의 용도 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| EP3359576A4 (fr) * | 2015-10-08 | 2019-08-28 | Zymeworks Inc. | Constructions de polypeptides de liaison à l'antigène comprenant des chaînes légères kappa et lambda et leurs utilisations |
| EP3397646A1 (fr) * | 2015-12-28 | 2018-11-07 | Massachusetts Institute of Technology | Anticorps bispécifiques ayant des mutations de région constante et leurs utilisations |
| EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| DK3411404T3 (da) | 2016-02-03 | 2023-01-30 | Amgen Res Munich Gmbh | Psma- og cd3-bispecifikke t-celleinddragende antistofkonstruktioner |
| US11291721B2 (en) | 2016-03-21 | 2022-04-05 | Marengo Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| EP3455243B1 (fr) | 2016-05-11 | 2021-03-24 | Cytiva BioProcess R&D AB | Matrice de séparation |
| CN109311948B (zh) | 2016-05-11 | 2022-09-16 | 思拓凡生物工艺研发有限公司 | 清洁和/或消毒分离基质的方法 |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| WO2017194592A1 (fr) | 2016-05-11 | 2017-11-16 | Ge Healthcare Bioprocess R&D Ab | Procédé de conservation d'une matrice de séparation |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| EP3559048A1 (fr) * | 2016-12-22 | 2019-10-30 | Eli Lilly and Company | Procédés de production d'anticorps bispécifiques fabs et igg |
| WO2018151820A1 (fr) | 2017-02-16 | 2018-08-23 | Elstar Therapeutics, Inc. | Molécules multifonctionnelles comprenant un ligand trimérique et leurs utilisations |
| JOP20190222A1 (ar) | 2017-04-11 | 2019-09-24 | Zymeworks Inc | الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3 |
| WO2018222901A1 (fr) | 2017-05-31 | 2018-12-06 | Elstar Therapeutics, Inc. | Molécules multispécifiques se liant à une protéine de leucémie myéloproliférative (mpl) et leurs utilisations |
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| DK3107938T3 (da) | 2022-07-11 |
| WO2015181805A9 (fr) | 2016-02-25 |
| CA2946503C (fr) | 2022-11-22 |
| CA2946503A1 (fr) | 2015-12-03 |
| RU2729467C2 (ru) | 2020-08-06 |
| US20220251242A1 (en) | 2022-08-11 |
| KR20170044613A (ko) | 2017-04-25 |
| AU2021202963A1 (en) | 2021-06-03 |
| HK1231490A1 (zh) | 2017-12-22 |
| US20170204199A1 (en) | 2017-07-20 |
| BR112016027888A2 (pt) | 2017-10-24 |
| EP4026850A1 (fr) | 2022-07-13 |
| US11306156B2 (en) | 2022-04-19 |
| AU2015265457A1 (en) | 2016-11-10 |
| MX2016015459A (es) | 2017-12-14 |
| AU2015265457B2 (en) | 2021-02-18 |
| KR102493430B1 (ko) | 2023-01-31 |
| EA201692476A1 (ru) | 2017-07-31 |
| RU2016145906A (ru) | 2018-05-23 |
| AU2021202963B2 (en) | 2024-02-15 |
| EP3107938A1 (fr) | 2016-12-28 |
| EP3107938A4 (fr) | 2018-02-28 |
| AU2024202649A1 (en) | 2024-05-16 |
| RU2016145906A3 (fr) | 2018-05-23 |
| MX2022006527A (es) | 2022-07-11 |
| WO2015181805A1 (fr) | 2015-12-03 |
| EP3107938B1 (fr) | 2022-05-04 |
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