CA3171651A1 - Methods of preparing chiral benzodiazepinone derivatives - Google Patents
Methods of preparing chiral benzodiazepinone derivativesInfo
- Publication number
- CA3171651A1 CA3171651A1 CA3171651A CA3171651A CA3171651A1 CA 3171651 A1 CA3171651 A1 CA 3171651A1 CA 3171651 A CA3171651 A CA 3171651A CA 3171651 A CA3171651 A CA 3171651A CA 3171651 A1 CA3171651 A1 CA 3171651A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- solvent
- combination
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062977316P | 2020-02-16 | 2020-02-16 | |
| US62/977,316 | 2020-02-16 | ||
| PCT/US2021/018137 WO2021163676A1 (en) | 2020-02-16 | 2021-02-16 | Methods of preparing chiral benzodiazepinone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3171651A1 true CA3171651A1 (en) | 2021-08-19 |
Family
ID=77291712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3171651A Pending CA3171651A1 (en) | 2020-02-16 | 2021-02-16 | Methods of preparing chiral benzodiazepinone derivatives |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12503449B2 (https=) |
| EP (1) | EP4107148A4 (https=) |
| JP (1) | JP2023513731A (https=) |
| KR (1) | KR20220143094A (https=) |
| CN (1) | CN115103836A (https=) |
| AU (1) | AU2021218456A1 (https=) |
| BR (1) | BR112022016249A2 (https=) |
| CA (1) | CA3171651A1 (https=) |
| IL (1) | IL295572A (https=) |
| MX (1) | MX2022010079A (https=) |
| WO (1) | WO2021163676A1 (https=) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0253571B1 (en) * | 1986-07-14 | 1989-08-23 | Merck & Co. Inc. | Process for resolution and race mization of amines with acidic alpha-hydrogens |
| NL9000386A (nl) * | 1990-02-16 | 1991-09-16 | Stamicarbon | Werkwijze voor de bereiding van optisch aktief aminozuuramide. |
| JPH0751555B2 (ja) | 1992-04-15 | 1995-06-05 | キヤノン株式会社 | ジイモニウム塩化合物 |
| BRPI0520554A2 (pt) * | 2005-09-19 | 2009-06-13 | Arrow Therapeutics Ltd | uso de uma benzodiazepina ou um sal farmaceuticamente aceitável do mesmo, método para tratar ou prevenir uma infecção por hcv em um paciente, derivado de benzodiazepina ou um sal famaceuticamente aceitável do mesmo, e, composição farmacêutica |
| WO2010073253A1 (en) | 2008-12-22 | 2010-07-01 | Natco Pharma Limited | Method for preparing an optically active frovatriptan |
| WO2013148554A1 (en) * | 2012-03-30 | 2013-10-03 | Merck Sharp & Dohme Corp. | Process for preparing fluoroleucine alkyl esters |
| CN105308030A (zh) * | 2012-09-21 | 2016-02-03 | 百时美施贵宝公司 | 烷基、氟烷基-1,4-苯并二氮杂*酮化合物 |
| EP2897942B1 (en) | 2012-09-21 | 2016-08-31 | Bristol-Myers Squibb Company | Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds as notch inhibitors |
| WO2014047392A1 (en) | 2012-09-21 | 2014-03-27 | Bristol-Myers Squibb Company | Fluoroalkyl-1,4-benzodiazepinone compounds |
| TWI614238B (zh) * | 2012-09-21 | 2018-02-11 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥 |
| JP6687596B2 (ja) | 2015-02-17 | 2020-04-22 | アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ | Ｎ−［４−（１−アミノエチル）−フェニル］−スルホンアミド誘導体のキラル分割方法 |
| CN105439939B (zh) | 2015-11-12 | 2018-12-04 | 四川恒康科技发展有限公司 | 一种(S)-N-Boc-3-羟基哌啶的合成方法 |
-
2021
- 2021-02-16 CN CN202180014113.5A patent/CN115103836A/zh active Pending
- 2021-02-16 JP JP2022548818A patent/JP2023513731A/ja active Pending
- 2021-02-16 MX MX2022010079A patent/MX2022010079A/es unknown
- 2021-02-16 CA CA3171651A patent/CA3171651A1/en active Pending
- 2021-02-16 WO PCT/US2021/018137 patent/WO2021163676A1/en not_active Ceased
- 2021-02-16 IL IL295572A patent/IL295572A/en unknown
- 2021-02-16 BR BR112022016249A patent/BR112022016249A2/pt unknown
- 2021-02-16 KR KR1020227032186A patent/KR20220143094A/ko active Pending
- 2021-02-16 EP EP21753186.2A patent/EP4107148A4/en active Pending
- 2021-02-16 US US17/799,680 patent/US12503449B2/en active Active
- 2021-02-16 AU AU2021218456A patent/AU2021218456A1/en active Pending
-
2025
- 2025-07-24 US US19/279,615 patent/US20250346565A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN115103836A (zh) | 2022-09-23 |
| MX2022010079A (es) | 2022-09-02 |
| US20250346565A1 (en) | 2025-11-13 |
| BR112022016249A2 (pt) | 2022-10-11 |
| EP4107148A1 (en) | 2022-12-28 |
| WO2021163676A1 (en) | 2021-08-19 |
| EP4107148A4 (en) | 2024-05-15 |
| IL295572A (en) | 2022-10-01 |
| US20230108536A1 (en) | 2023-04-06 |
| US12503449B2 (en) | 2025-12-23 |
| AU2021218456A1 (en) | 2022-09-22 |
| KR20220143094A (ko) | 2022-10-24 |
| JP2023513731A (ja) | 2023-04-03 |
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