JP2023513731A - キラルベンゾジアゼピノン誘導体の調製方法 - Google Patents

キラルベンゾジアゼピノン誘導体の調製方法 Download PDF

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JP2023513731A
JP2023513731A JP2022548818A JP2022548818A JP2023513731A JP 2023513731 A JP2023513731 A JP 2023513731A JP 2022548818 A JP2022548818 A JP 2022548818A JP 2022548818 A JP2022548818 A JP 2022548818A JP 2023513731 A JP2023513731 A JP 2023513731A
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JP2023513731A5 (https=
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チマルスティ、クリストファー・エム
ラホティ、アーナンドクマール・マダンラル
ラジャ ゴーパール レッディ ダラム、マダン
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アヤラ ファーマシューティカルズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2022548818A 2020-02-16 2021-02-16 キラルベンゾジアゼピノン誘導体の調製方法 Pending JP2023513731A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062977316P 2020-02-16 2020-02-16
US62/977,316 2020-02-16
PCT/US2021/018137 WO2021163676A1 (en) 2020-02-16 2021-02-16 Methods of preparing chiral benzodiazepinone derivatives

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JP2023513731A true JP2023513731A (ja) 2023-04-03
JP2023513731A5 JP2023513731A5 (https=) 2024-02-22

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JP2022548818A Pending JP2023513731A (ja) 2020-02-16 2021-02-16 キラルベンゾジアゼピノン誘導体の調製方法

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US (2) US12503449B2 (https=)
EP (1) EP4107148A4 (https=)
JP (1) JP2023513731A (https=)
KR (1) KR20220143094A (https=)
CN (1) CN115103836A (https=)
AU (1) AU2021218456A1 (https=)
BR (1) BR112022016249A2 (https=)
CA (1) CA3171651A1 (https=)
IL (1) IL295572A (https=)
MX (1) MX2022010079A (https=)
WO (1) WO2021163676A1 (https=)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6323824A (ja) * 1986-07-14 1988-02-01 メルク　エンド　カムパニ−　インコ−ポレ−テツド 酸性α−水素を有するアミンの光学分割およびラセミ化方法
JPH05178805A (ja) * 1990-02-16 1993-07-20 Dsm Nv 光学的に活性なアミノ酸アミドの製法
JP2009508830A (ja) * 2005-09-19 2009-03-05 アロー セラピューティクス リミテッド Ｃ型肝炎感染症を治療するためのベンゾジアゼピン誘導体
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
JP2015529253A (ja) * 2012-09-21 2015-10-05 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｎｏｔｃｈ阻害剤としてのフルオロアルキルおよびフルオロシクロアルキル１，４−ベンゾジアゼピノン化合物
JP2015529252A (ja) * 2012-09-21 2015-10-05 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ フルオロアルキル−１，４−ベンゾジアゼピノン化合物
JP2015530411A (ja) * 2012-09-21 2015-10-15 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｎｏｔｃｈ阻害剤としてのビス（フルオロアルキル）−１，４−ベンゾジアゼピノン化合物
JP2015534554A (ja) * 2012-09-21 2015-12-03 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ アルキル，フルオロアルキル−１，４−ベンゾジアゼピノン化合物
CN105439939A (zh) * 2015-11-12 2016-03-30 四川恒康科技发展有限公司 一种(S)-N-Boc-3-羟基哌啶的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0751555B2 (ja) 1992-04-15 1995-06-05 キヤノン株式会社 ジイモニウム塩化合物
WO2013148554A1 (en) * 2012-03-30 2013-10-03 Merck Sharp & Dohme Corp. Process for preparing fluoroleucine alkyl esters
JP6687596B2 (ja) 2015-02-17 2020-04-22 アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ Ｎ−［４−（１−アミノエチル）−フェニル］−スルホンアミド誘導体のキラル分割方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6323824A (ja) * 1986-07-14 1988-02-01 メルク　エンド　カムパニ−　インコ−ポレ−テツド 酸性α−水素を有するアミンの光学分割およびラセミ化方法
JPH05178805A (ja) * 1990-02-16 1993-07-20 Dsm Nv 光学的に活性なアミノ酸アミドの製法
JP2009508830A (ja) * 2005-09-19 2009-03-05 アロー セラピューティクス リミテッド Ｃ型肝炎感染症を治療するためのベンゾジアゼピン誘導体
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
JP2015529253A (ja) * 2012-09-21 2015-10-05 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｎｏｔｃｈ阻害剤としてのフルオロアルキルおよびフルオロシクロアルキル１，４−ベンゾジアゼピノン化合物
JP2015529252A (ja) * 2012-09-21 2015-10-05 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ フルオロアルキル−１，４−ベンゾジアゼピノン化合物
JP2015530411A (ja) * 2012-09-21 2015-10-15 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｎｏｔｃｈ阻害剤としてのビス（フルオロアルキル）−１，４−ベンゾジアゼピノン化合物
JP2015534554A (ja) * 2012-09-21 2015-12-03 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ アルキル，フルオロアルキル−１，４−ベンゾジアゼピノン化合物
CN105439939A (zh) * 2015-11-12 2016-03-30 四川恒康科技发展有限公司 一种(S)-N-Boc-3-羟基哌啶的合成方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
化学便覧 応用化学編 第５版, vol. 第２刷, JPN6024043327, 2001, pages 320 - 322, ISSN: 0005577390 *

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Publication number Publication date
CN115103836A (zh) 2022-09-23
MX2022010079A (es) 2022-09-02
US20250346565A1 (en) 2025-11-13
BR112022016249A2 (pt) 2022-10-11
CA3171651A1 (en) 2021-08-19
EP4107148A1 (en) 2022-12-28
WO2021163676A1 (en) 2021-08-19
EP4107148A4 (en) 2024-05-15
IL295572A (en) 2022-10-01
US20230108536A1 (en) 2023-04-06
US12503449B2 (en) 2025-12-23
AU2021218456A1 (en) 2022-09-22
KR20220143094A (ko) 2022-10-24

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