KR20220143094A - 키랄 벤조디아제피논 유도체의 제조 방법 - Google Patents

키랄 벤조디아제피논 유도체의 제조 방법 Download PDF

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KR20220143094A
KR20220143094A KR1020227032186A KR20227032186A KR20220143094A KR 20220143094 A KR20220143094 A KR 20220143094A KR 1020227032186 A KR1020227032186 A KR 1020227032186A KR 20227032186 A KR20227032186 A KR 20227032186A KR 20220143094 A KR20220143094 A KR 20220143094A
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South Korea
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compound
formula
solvent
solvents
represented
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KR1020227032186A
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English (en)
Korean (ko)
Inventor
크리스토퍼 엠. 치마루스티
아난드쿠마르 마단랄 라호티
마단 라자 고팔 레디 다람
Original Assignee
아얄라 파마큐티컬즈 아이엔씨.
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Publication of KR20220143094A publication Critical patent/KR20220143094A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020227032186A 2020-02-16 2021-02-16 키랄 벤조디아제피논 유도체의 제조 방법 Pending KR20220143094A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062977316P 2020-02-16 2020-02-16
US62/977,316 2020-02-16
PCT/US2021/018137 WO2021163676A1 (en) 2020-02-16 2021-02-16 Methods of preparing chiral benzodiazepinone derivatives

Publications (1)

Publication Number Publication Date
KR20220143094A true KR20220143094A (ko) 2022-10-24

Family

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Family Applications (1)

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KR1020227032186A Pending KR20220143094A (ko) 2020-02-16 2021-02-16 키랄 벤조디아제피논 유도체의 제조 방법

Country Status (11)

Country Link
US (2) US12503449B2 (https=)
EP (1) EP4107148A4 (https=)
JP (1) JP2023513731A (https=)
KR (1) KR20220143094A (https=)
CN (1) CN115103836A (https=)
AU (1) AU2021218456A1 (https=)
BR (1) BR112022016249A2 (https=)
CA (1) CA3171651A1 (https=)
IL (1) IL295572A (https=)
MX (1) MX2022010079A (https=)
WO (1) WO2021163676A1 (https=)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0253571B1 (en) * 1986-07-14 1989-08-23 Merck & Co. Inc. Process for resolution and race mization of amines with acidic alpha-hydrogens
NL9000386A (nl) * 1990-02-16 1991-09-16 Stamicarbon Werkwijze voor de bereiding van optisch aktief aminozuuramide.
JPH0751555B2 (ja) 1992-04-15 1995-06-05 キヤノン株式会社 ジイモニウム塩化合物
BRPI0520554A2 (pt) * 2005-09-19 2009-06-13 Arrow Therapeutics Ltd uso de uma benzodiazepina ou um sal farmaceuticamente aceitável do mesmo, método para tratar ou prevenir uma infecção por hcv em um paciente, derivado de benzodiazepina ou um sal famaceuticamente aceitável do mesmo, e, composição farmacêutica
WO2010073253A1 (en) 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
WO2013148554A1 (en) * 2012-03-30 2013-10-03 Merck Sharp & Dohme Corp. Process for preparing fluoroleucine alkyl esters
CN105308030A (zh) * 2012-09-21 2016-02-03 百时美施贵宝公司 烷基、氟烷基-1,4-苯并二氮杂*酮化合物
EP2897942B1 (en) 2012-09-21 2016-08-31 Bristol-Myers Squibb Company Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds as notch inhibitors
WO2014047392A1 (en) 2012-09-21 2014-03-27 Bristol-Myers Squibb Company Fluoroalkyl-1,4-benzodiazepinone compounds
TWI614238B (zh) * 2012-09-21 2018-02-11 必治妥美雅史谷比公司 雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥
JP6687596B2 (ja) 2015-02-17 2020-04-22 アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ Ｎ−［４−（１−アミノエチル）−フェニル］−スルホンアミド誘導体のキラル分割方法
CN105439939B (zh) 2015-11-12 2018-12-04 四川恒康科技发展有限公司 一种(S)-N-Boc-3-羟基哌啶的合成方法

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Publication number Publication date
CN115103836A (zh) 2022-09-23
MX2022010079A (es) 2022-09-02
US20250346565A1 (en) 2025-11-13
BR112022016249A2 (pt) 2022-10-11
CA3171651A1 (en) 2021-08-19
EP4107148A1 (en) 2022-12-28
WO2021163676A1 (en) 2021-08-19
EP4107148A4 (en) 2024-05-15
IL295572A (en) 2022-10-01
US20230108536A1 (en) 2023-04-06
US12503449B2 (en) 2025-12-23
AU2021218456A1 (en) 2022-09-22
JP2023513731A (ja) 2023-04-03

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