CA3159182A1 - Cell-permeable cyclic peptides and uses thereof - Google Patents

Cell-permeable cyclic peptides and uses thereof Download PDF

Info

Publication number
CA3159182A1
CA3159182A1 CA3159182A CA3159182A CA3159182A1 CA 3159182 A1 CA3159182 A1 CA 3159182A1 CA 3159182 A CA3159182 A CA 3159182A CA 3159182 A CA3159182 A CA 3159182A CA 3159182 A1 CA3159182 A1 CA 3159182A1
Authority
CA
Canada
Prior art keywords
independently selected
optionally substituted
cyclic peptide
halo
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3159182A
Other languages
English (en)
French (fr)
Inventor
Cameron PYE
Joshua SCHWOCHERT
Seth Rubin
Anthony Silvestri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unnatural Products Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA3159182A1 publication Critical patent/CA3159182A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3159182A 2019-11-21 2020-11-20 Cell-permeable cyclic peptides and uses thereof Pending CA3159182A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962938864P 2019-11-21 2019-11-21
US62/938,864 2019-11-21
US202063047178P 2020-07-01 2020-07-01
US63/047,178 2020-07-01
PCT/US2020/061596 WO2021102322A1 (en) 2019-11-21 2020-11-20 Cell-permeable cyclic peptides and uses thereof

Publications (1)

Publication Number Publication Date
CA3159182A1 true CA3159182A1 (en) 2021-05-27

Family

ID=75981727

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3159182A Pending CA3159182A1 (en) 2019-11-21 2020-11-20 Cell-permeable cyclic peptides and uses thereof

Country Status (7)

Country Link
US (1) US20220411471A1 (https=)
EP (1) EP4061397A4 (https=)
JP (1) JP7836759B2 (https=)
CN (1) CN115297883A (https=)
CA (1) CA3159182A1 (https=)
IL (1) IL293239A (https=)
WO (1) WO2021102322A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202313092A (zh) * 2021-05-26 2023-04-01 美商非自然產物公司 細胞可穿透環狀肽及其用途
TW202417032A (zh) 2022-08-23 2024-05-01 日商富士軟片股份有限公司 環肽或其鹽及ｍｄｍｘ抑制劑
TW202417465A (zh) 2022-08-23 2024-05-01 日商富士軟片股份有限公司 環肽或其鹽及ｍｄｍｘ抑制劑

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166003A1 (en) * 1999-06-14 2003-09-04 Cochran Andrea G. Structured peptide scaffold for displaying turn libraries on phage
AU2008360223B2 (en) * 2008-08-08 2014-06-19 Polyphor Ag Template-fixed peptidomimetics
JP2014001189A (ja) * 2012-06-20 2014-01-09 Osaka Prefecture Univ 抗腫瘍ペプチド化合物
EP3243522A1 (en) * 2016-05-10 2017-11-15 Université Pierre et Marie Curie (Paris 6) Agonist agents of cd47 inducing programmed cell death and their use in the treatments of diseases associated with defects in programmed cell death
CN110114075B (zh) * 2016-11-09 2024-01-12 俄亥俄州国家创新基金会 含有二硫化物的细胞穿透肽及其制备和使用方法
US11446388B2 (en) * 2016-12-23 2022-09-20 Heidelberg Pharma Research Gmbh Amanitin antibody conjugates
CN110452289A (zh) * 2019-07-10 2019-11-15 江苏申琅生物科技有限公司 一类新型mdm2环肽抑制剂的设计及其制备方法

Also Published As

Publication number Publication date
IL293239A (en) 2022-07-01
CN115297883A (zh) 2022-11-04
US20220411471A1 (en) 2022-12-29
EP4061397A1 (en) 2022-09-28
WO2021102322A1 (en) 2021-05-27
EP4061397A4 (en) 2023-11-29
JP2023502745A (ja) 2023-01-25
JP7836759B2 (ja) 2026-03-27

Similar Documents

Publication Publication Date Title
CA2986141C (en) Compounds targeting proteins, compositions, methods, and uses thereof
CA3159182A1 (en) Cell-permeable cyclic peptides and uses thereof
US20250032462A1 (en) Bax activators and uses thereof in cancer therapy
JP2015528447A (ja) Ｉａｐタンパク質の二価阻害薬およびそれを用いた治療方法
WO2019232724A1 (en) Compounds as nuclear transport modulators and uses thereof
Zhu et al. Ugi reaction-assisted assembly of covalent PROTACs against glutathione peroxidase 4
JP2021521164A (ja) Ｆｏｘｍ１阻害剤組成物およびこれを使用する方法
Yao et al. Discovery of novel hydrazinyl thiazole derivatives as potent anticancer agents by inhibiting eIF4E/eIF4G interactions
WO2023196993A1 (en) METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
US20230331679A1 (en) Naphthalene monoimide compounds and methods thereof
US20240199702A1 (en) Cell-permeable cyclic peptides and uses thereof
US9908890B2 (en) Selective inhibitors of constitutive androstane receptor
AU2019218153B2 (en) Therapeutic drug for neurodegenerative disease and application thereof
US11466008B2 (en) Co-crystals of neflamapimod (VX-745)
JP2015040179A (ja) 免疫抑制剤
JP2024031105A (ja) 線維症治療又は予防薬
US20170348375A1 (en) Dislodgement and release of hsc from the bone marrow stem cell niche using alpha9 integrin antagonists
US20260008755A1 (en) Inhibitors of protein arginine deiminase 1 and methods of preparation and use thereof
JP7644471B2 (ja) オートファジー阻害剤
US20200397901A1 (en) Photoresponsive smoothened ligand
JP2021195345A (ja) 低酸素誘導因子阻害剤
WO2020025789A1 (en) Elafibranor salts
NZ786051A (en) Bicyclic compounds for diagnosis and therapy
HK1163689B (en) Methods and compositions for modulating ire1, src, and abl activity
HK1163689A1 (en) Methods and compositions for modulating ire1, src, and abl activity

Legal Events

Date Code Title Description
MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 4TH ANNIV.) - STANDARD

Year of fee payment: 4

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20241111

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20241111

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20241111

D11 Substantive examination requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D11-D117 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION RECEIVED

Effective date: 20241114

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P11-P101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - VOLUNTARY AMENDMENT

Effective date: 20241114

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20241114

D00 Search and/or examination requested or commenced

Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D00-D118 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION REQUIREMENTS DETERMINED COMPLIANT

Effective date: 20241219

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20241219

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20241219

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20241219

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20250424

D11 Substantive examination requested

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D11-D155 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ALL REQUIREMENTS FOR EXAMINATION DETERMINED COMPLIANT

Effective date: 20250430

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD

Year of fee payment: 5

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20251110

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20251110