CN115297883A - 细胞渗透性环肽及其用途 - Google Patents

细胞渗透性环肽及其用途 Download PDF

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Publication number
CN115297883A
CN115297883A CN202080093855.7A CN202080093855A CN115297883A CN 115297883 A CN115297883 A CN 115297883A CN 202080093855 A CN202080093855 A CN 202080093855A CN 115297883 A CN115297883 A CN 115297883A
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CN
China
Prior art keywords
independently selected
alkyl
substituted
optionally substituted
cyclic peptide
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Pending
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CN202080093855.7A
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English (en)
Chinese (zh)
Inventor
C·派伊
J·施沃赫特
S·鲁宾
A·西尔维斯特里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anetsche Products Co ltd
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Anetsche Products Co ltd
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Publication date
Application filed by Anetsche Products Co ltd filed Critical Anetsche Products Co ltd
Publication of CN115297883A publication Critical patent/CN115297883A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202080093855.7A 2019-11-21 2020-11-20 细胞渗透性环肽及其用途 Pending CN115297883A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962938864P 2019-11-21 2019-11-21
US62/938,864 2019-11-21
US202063047178P 2020-07-01 2020-07-01
US63/047,178 2020-07-01
PCT/US2020/061596 WO2021102322A1 (en) 2019-11-21 2020-11-20 Cell-permeable cyclic peptides and uses thereof

Publications (1)

Publication Number Publication Date
CN115297883A true CN115297883A (zh) 2022-11-04

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ID=75981727

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080093855.7A Pending CN115297883A (zh) 2019-11-21 2020-11-20 细胞渗透性环肽及其用途

Country Status (7)

Country Link
US (1) US20220411471A1 (https=)
EP (1) EP4061397A4 (https=)
JP (1) JP7836759B2 (https=)
CN (1) CN115297883A (https=)
CA (1) CA3159182A1 (https=)
IL (1) IL293239A (https=)
WO (1) WO2021102322A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202313092A (zh) * 2021-05-26 2023-04-01 美商非自然產物公司 細胞可穿透環狀肽及其用途
TW202417032A (zh) 2022-08-23 2024-05-01 日商富士軟片股份有限公司 環肽或其鹽及ｍｄｍｘ抑制劑
TW202417465A (zh) 2022-08-23 2024-05-01 日商富士軟片股份有限公司 環肽或其鹽及ｍｄｍｘ抑制劑

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110230426A1 (en) * 2008-08-08 2011-09-22 Polyphor Ag Template-fixed peptidomimetics
JP2014001189A (ja) * 2012-06-20 2014-01-09 Osaka Prefecture Univ 抗腫瘍ペプチド化合物
CN110452289A (zh) * 2019-07-10 2019-11-15 江苏申琅生物科技有限公司 一类新型mdm2环肽抑制剂的设计及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166003A1 (en) * 1999-06-14 2003-09-04 Cochran Andrea G. Structured peptide scaffold for displaying turn libraries on phage
EP3243522A1 (en) * 2016-05-10 2017-11-15 Université Pierre et Marie Curie (Paris 6) Agonist agents of cd47 inducing programmed cell death and their use in the treatments of diseases associated with defects in programmed cell death
CN110114075B (zh) * 2016-11-09 2024-01-12 俄亥俄州国家创新基金会 含有二硫化物的细胞穿透肽及其制备和使用方法
US11446388B2 (en) * 2016-12-23 2022-09-20 Heidelberg Pharma Research Gmbh Amanitin antibody conjugates

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110230426A1 (en) * 2008-08-08 2011-09-22 Polyphor Ag Template-fixed peptidomimetics
JP2014001189A (ja) * 2012-06-20 2014-01-09 Osaka Prefecture Univ 抗腫瘍ペプチド化合物
CN110452289A (zh) * 2019-07-10 2019-11-15 江苏申琅生物科技有限公司 一类新型mdm2环肽抑制剂的设计及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RUDI FASAN等: "Structure-activity studies in a family of beta-hairpin protein epitope mimetic inhibitors of the p53-HDM2 protein-protein interaction", CHEMBIOCHEM, vol. 7, no. 3, 31 March 2006 (2006-03-31), pages 515 - 526, XP002569253, DOI: 10.1002/CBIC.200500452 *
RUDI FASAN等: "Using a β-Hairpin To Mimic an α-Helix: Cyclic Peptidomimetic Inhibitors of the p53–HDM2 Protein–Protein Interaction", ANGEWANDTE, vol. 43, no. 16, 6 April 2004 (2004-04-06), pages 2109 - 2112, XP002569254, DOI: 10.1002/ANIE.200353242 *

Also Published As

Publication number Publication date
IL293239A (en) 2022-07-01
CA3159182A1 (en) 2021-05-27
US20220411471A1 (en) 2022-12-29
EP4061397A1 (en) 2022-09-28
WO2021102322A1 (en) 2021-05-27
EP4061397A4 (en) 2023-11-29
JP2023502745A (ja) 2023-01-25
JP7836759B2 (ja) 2026-03-27

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