JP7836759B2 - 細胞透過性環状ペプチドおよびその使用 - Google Patents

細胞透過性環状ペプチドおよびその使用

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Publication number
JP7836759B2
JP7836759B2 JP2022529831A JP2022529831A JP7836759B2 JP 7836759 B2 JP7836759 B2 JP 7836759B2 JP 2022529831 A JP2022529831 A JP 2022529831A JP 2022529831 A JP2022529831 A JP 2022529831A JP 7836759 B2 JP7836759 B2 JP 7836759B2
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JP
Japan
Prior art keywords
independently selected
alkyl
optionally substituted
hydrogen
och3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022529831A
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English (en)
Japanese (ja)
Other versions
JPWO2021102322A5 (https=
JP2023502745A5 (https=
JP2023502745A (ja
Inventor
パイ，キャメロン
シュウォチャート，ジョシュア
ルビン，セス
シルベストリ，アンソニー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unnatural Products Inc
Original Assignee
Unnatural Products Inc
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Publication date
Application filed by Unnatural Products Inc filed Critical Unnatural Products Inc
Publication of JP2023502745A publication Critical patent/JP2023502745A/ja
Publication of JPWO2021102322A5 publication Critical patent/JPWO2021102322A5/ja
Publication of JP2023502745A5 publication Critical patent/JP2023502745A5/ja
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Publication of JP7836759B2 publication Critical patent/JP7836759B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2022529831A 2019-11-21 2020-11-20 細胞透過性環状ペプチドおよびその使用 Active JP7836759B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962938864P 2019-11-21 2019-11-21
US62/938,864 2019-11-21
US202063047178P 2020-07-01 2020-07-01
US63/047,178 2020-07-01
PCT/US2020/061596 WO2021102322A1 (en) 2019-11-21 2020-11-20 Cell-permeable cyclic peptides and uses thereof

Publications (4)

Publication Number Publication Date
JP2023502745A JP2023502745A (ja) 2023-01-25
JPWO2021102322A5 JPWO2021102322A5 (https=) 2023-12-01
JP2023502745A5 JP2023502745A5 (https=) 2023-12-01
JP7836759B2 true JP7836759B2 (ja) 2026-03-27

Family

ID=75981727

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022529831A Active JP7836759B2 (ja) 2019-11-21 2020-11-20 細胞透過性環状ペプチドおよびその使用

Country Status (7)

Country Link
US (1) US20220411471A1 (https=)
EP (1) EP4061397A4 (https=)
JP (1) JP7836759B2 (https=)
CN (1) CN115297883A (https=)
CA (1) CA3159182A1 (https=)
IL (1) IL293239A (https=)
WO (1) WO2021102322A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202313092A (zh) * 2021-05-26 2023-04-01 美商非自然產物公司 細胞可穿透環狀肽及其用途
TW202417032A (zh) 2022-08-23 2024-05-01 日商富士軟片股份有限公司 環肽或其鹽及ｍｄｍｘ抑制劑
TW202417465A (zh) 2022-08-23 2024-05-01 日商富士軟片股份有限公司 環肽或其鹽及ｍｄｍｘ抑制劑

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014001189A (ja) 2012-06-20 2014-01-09 Osaka Prefecture Univ 抗腫瘍ペプチド化合物
WO2018089648A2 (en) 2016-11-09 2018-05-17 Ohio State Innovation Foundation Di-sulfide containing cell penetrating peptides and methods of making and using thereof
CN110452289A (zh) 2019-07-10 2019-11-15 江苏申琅生物科技有限公司 一类新型mdm2环肽抑制剂的设计及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166003A1 (en) * 1999-06-14 2003-09-04 Cochran Andrea G. Structured peptide scaffold for displaying turn libraries on phage
AU2008360223B2 (en) * 2008-08-08 2014-06-19 Polyphor Ag Template-fixed peptidomimetics
EP3243522A1 (en) * 2016-05-10 2017-11-15 Université Pierre et Marie Curie (Paris 6) Agonist agents of cd47 inducing programmed cell death and their use in the treatments of diseases associated with defects in programmed cell death
US11446388B2 (en) * 2016-12-23 2022-09-20 Heidelberg Pharma Research Gmbh Amanitin antibody conjugates

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014001189A (ja) 2012-06-20 2014-01-09 Osaka Prefecture Univ 抗腫瘍ペプチド化合物
WO2018089648A2 (en) 2016-11-09 2018-05-17 Ohio State Innovation Foundation Di-sulfide containing cell penetrating peptides and methods of making and using thereof
CN110452289A (zh) 2019-07-10 2019-11-15 江苏申琅生物科技有限公司 一类新型mdm2环肽抑制剂的设计及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ChemBioChem，2006年，Vol.7，pp.515-526
ChemMedChem，2016年，Vol.11，pp.1060-1068

Also Published As

Publication number Publication date
IL293239A (en) 2022-07-01
CA3159182A1 (en) 2021-05-27
CN115297883A (zh) 2022-11-04
US20220411471A1 (en) 2022-12-29
EP4061397A1 (en) 2022-09-28
WO2021102322A1 (en) 2021-05-27
EP4061397A4 (en) 2023-11-29
JP2023502745A (ja) 2023-01-25

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