CA3152591C - Lung cancer biomarkers and uses thereof - Google Patents

Lung cancer biomarkers and uses thereof Download PDF

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Publication number
CA3152591C
CA3152591C CA3152591A CA3152591A CA3152591C CA 3152591 C CA3152591 C CA 3152591C CA 3152591 A CA3152591 A CA 3152591A CA 3152591 A CA3152591 A CA 3152591A CA 3152591 C CA3152591 C CA 3152591C
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CA
Canada
Prior art keywords
biomarkers
biomarker
lung cancer
individual
aptamer
Prior art date
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Active
Application number
CA3152591A
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English (en)
French (fr)
Other versions
CA3152591A1 (en
Inventor
Larry Gold
Marty Stanton
Edward N. Brody
Rachel M. Ostroff
Dominic Zichi
Alex A. E. Stewart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Somalogic Operating Co Inc
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Somalogic Operating Co Inc
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Publication date
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Publication of CA3152591A1 publication Critical patent/CA3152591A1/en
Application granted granted Critical
Publication of CA3152591C publication Critical patent/CA3152591C/en
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • G01N33/5752—
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/12—Pulmonary diseases
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Mathematical Physics (AREA)
  • Data Mining & Analysis (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Computational Mathematics (AREA)
  • Databases & Information Systems (AREA)
  • Biophysics (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Plant Pathology (AREA)
  • Pure & Applied Mathematics (AREA)
  • Algebra (AREA)
  • Software Systems (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA3152591A 2008-09-09 2009-09-09 Lung cancer biomarkers and uses thereof Active CA3152591C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9559308P 2008-09-09 2008-09-09
US61/095,593 2008-09-09
US15283709P 2009-02-16 2009-02-16
US61/152,837 2009-02-16
CA3011730A CA3011730C (en) 2008-09-09 2009-09-09 Lung cancer biomarkers and uses thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3011730A Division CA3011730C (en) 2008-09-09 2009-09-09 Lung cancer biomarkers and uses thereof

Publications (2)

Publication Number Publication Date
CA3152591A1 CA3152591A1 (en) 2010-03-18
CA3152591C true CA3152591C (en) 2023-08-29

Family

ID=42005456

Family Applications (3)

Application Number Title Priority Date Filing Date
CA3152591A Active CA3152591C (en) 2008-09-09 2009-09-09 Lung cancer biomarkers and uses thereof
CA2734535A Active CA2734535C (en) 2008-09-09 2009-09-09 Lung cancer biomarkers and uses thereof
CA3011730A Active CA3011730C (en) 2008-09-09 2009-09-09 Lung cancer biomarkers and uses thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2734535A Active CA2734535C (en) 2008-09-09 2009-09-09 Lung cancer biomarkers and uses thereof
CA3011730A Active CA3011730C (en) 2008-09-09 2009-09-09 Lung cancer biomarkers and uses thereof

Country Status (14)

Country Link
EP (1) EP2340506B1 (enExample)
JP (1) JP5701212B2 (enExample)
KR (1) KR101658347B1 (enExample)
CN (2) CN102209968B (enExample)
AU (2) AU2009291811B2 (enExample)
CA (3) CA3152591C (enExample)
DK (1) DK2340506T3 (enExample)
ES (1) ES2559758T3 (enExample)
GB (1) GB2478441B (enExample)
HK (1) HK1204062A1 (enExample)
HR (1) HRP20160127T1 (enExample)
MX (1) MX2011002322A (enExample)
SI (1) SI2340506T1 (enExample)
WO (1) WO2010030697A1 (enExample)

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US10359425B2 (en) 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
EP3257953B1 (en) 2009-03-12 2018-09-26 Cancer Prevention And Cure, Ltd. Methods of identification, assessment, prevention and therapy of lung diseases and kits thereof including gender-based disease identification, assessment, prevention and therapy
BR112012032537B8 (pt) * 2010-07-09 2022-10-18 Somalogic Inc Métodos para diagnosticar se um indivíduo tem ou não câncer de pulmão de não pequenas células, ou para fornecer informações sobre câncer de pulmão de não pequenas células em um indivíduo
MX350533B (es) 2010-08-13 2017-09-08 Somalogic Inc Biomarcadores de cancer pancreatico y usos de los mismos.
CA2832480C (en) * 2011-04-07 2022-05-31 The Scripps Research Institute High-throughput screening for compounds modulating expression of cellular macromolecules
CA2834383A1 (en) * 2011-04-29 2012-11-01 Cancer Prevention And Cure, Ltd. Methods of identification and diagnosis of lung diseases using classification systems and kits thereof
ES2674318T3 (es) * 2011-10-24 2018-06-28 Somalogic, Inc. Biomarcadores de cáncer de pulmón y usos de los mismos
US9304137B2 (en) 2011-12-21 2016-04-05 Integrated Diagnostics, Inc. Compositions, methods and kits for diagnosis of lung cancer
US11913957B2 (en) 2011-12-21 2024-02-27 Biodesix, Inc. Compositions, methods and kits for diagnosis of lung cancer
EP2795330B1 (en) 2011-12-21 2017-07-19 Integrated Diagnostics Inc. Methods for diagnosis of lung cancer
RU2629799C2 (ru) * 2012-02-17 2017-09-04 Конинклейке Филипс Н.В. Оценка и наблюдение острого повреждения легких (ali)/синдрома острой дыхательной недостаточности (ards)
WO2014074682A1 (en) 2012-11-07 2014-05-15 Somalogic, Inc. Chronic obstructive pulmonary disease (copd) biomarkers and uses thereof
JP6645703B2 (ja) 2013-11-07 2020-02-14 メディアル リサーチ リミテッド 肺癌のリスクを評価する方法およびシステム
CN108026584B (zh) * 2015-09-11 2021-12-10 适体科学株式会社 非小细胞肺癌诊断用蛋白质生物标志物组及利用其的非小细胞肺癌诊断方法
FR3050269B1 (fr) * 2016-04-15 2018-05-11 Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris (Espci) Procede de selection et de recuperation de produits et systeme associe
CN105823665A (zh) * 2016-05-13 2016-08-03 北京九州柏林生物科技有限公司 生物组织样本制备套液
CN109715830A (zh) * 2016-06-21 2019-05-03 威斯塔解剖学和生物学研究所 用于使用基因表达谱诊断肺癌的组合物和方法
JP6280997B1 (ja) * 2016-10-31 2018-02-14 株式会社Preferred Networks 疾患の罹患判定装置、疾患の罹患判定方法、疾患の特徴抽出装置及び疾患の特徴抽出方法
CN110709936A (zh) 2017-04-04 2020-01-17 肺癌蛋白质组学有限责任公司 用于早期肺癌预后的基于血浆的蛋白质概况分析
WO2019046814A1 (en) 2017-09-01 2019-03-07 Venn Biosciences Corporation IDENTIFICATION AND USE OF GLYCOPEPTIDES AS BIOMARKERS FOR THE DIAGNOSIS AND MONITORING OF TREATMENT
US11885815B2 (en) 2017-11-22 2024-01-30 Gritstone Bio, Inc. Reducing junction epitope presentation for neoantigens
US12227808B2 (en) 2017-12-19 2025-02-18 The Wistar Institute Of Anatomy And Biology Compostions and methods for diagnosing lung cancers using gene expression profiles
CN112638845B (zh) * 2018-06-22 2024-07-30 私募蛋白质体运营有限公司 改进的蛋白质组学多重测定
JP7691373B2 (ja) * 2019-06-21 2025-06-11 ナショナル ユニヴァーシティー オブ シンガポール 肺癌の可能性を判定するための方法
CN110579611B (zh) * 2019-09-18 2023-01-31 郑州大学 一种用于肺癌早期筛查和诊断的联合检测血清标志物、试剂盒及检测方法
CN111047609B (zh) * 2020-03-13 2020-07-24 北京深睿博联科技有限责任公司 肺炎病灶分割方法和装置
WO2022073502A1 (zh) * 2020-10-10 2022-04-14 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 生物标志物在制备肺癌检测试剂中的用途和方法
CN112557514B (zh) * 2020-12-22 2021-09-21 中国海洋大学 手持式海底沉积物样品剖面声学全自动测量装置
WO2025137139A1 (en) * 2023-12-18 2025-06-26 Caris Mpi, Inc. Dynamic tissue typing

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US6596503B1 (en) * 2000-08-18 2003-07-22 East Carolina University Monoclonal antibody DS6, tumor-associated antigen CA6, and methods of use thereof
US20030190602A1 (en) * 2001-03-12 2003-10-09 Monogen, Inc. Cell-based detection and differentiation of disease states
CA2440753A1 (en) * 2001-03-12 2002-09-19 Monogen, Inc Cell-based detection and differentiation of disease states
EP1463928A2 (en) * 2001-04-18 2004-10-06 Protein Design Labs Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer
US8014952B2 (en) * 2002-12-18 2011-09-06 Queen Elizabeth Hospital Serum biomarkers in lung cancer
CN1225477C (zh) * 2003-03-28 2005-11-02 上海市疾病预防控制中心 肺癌早期血清特异蛋白及其应用
CN1455257A (zh) * 2003-05-23 2003-11-12 北京师范大学 一种利用表面修饰蛋白芯片进行肺癌诊断方法
CN1977052B (zh) * 2004-03-23 2012-09-05 肿瘤疗法科学股份有限公司 与kif11基因相关的双-链分子及载体
JP2005304497A (ja) * 2004-03-25 2005-11-04 Joji Inasawa 特定の癌関連遺伝子を用いる癌の検出方法及び癌の抑制方法
US7456027B2 (en) * 2004-04-15 2008-11-25 University Of Florida Research Foundation, Inc. Proteolytic biomarkers for traumatic injury to the nervous system
BRPI0510266A (pt) * 2004-04-26 2007-10-30 Childrens Medical Center métodos para a detecção de uma doença ou distúrbio angiogênico em um indivìduo, para a detecção de cáncer em um indivìduo, para o tratamento de um indivìduo afetado com uma doença ou distúrbio angiogênico, para a determinação da probabilidade de eficácia de uma terapia anti-angiogênica, para a determinação da eficácia de uma terapia de teste na modulação dos nìveis de reguladores angiogênicos de plaqueta, para a criação de um registro ou perfil de plaqueta para uma doença ou distúrbio angiogênico e para a monitoração da eficácia de uma terapia em um indivìduo com uma doença ou distúrbio angiogênico
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EP2155908A4 (en) * 2007-05-18 2010-12-01 Univ Southern California GERMINAL LINEAR POLYMORPHISMS IN THE ANGIOGENIC PATHWAY AS PREDICTORS OF A TUMOR RECIPIENT IN THE TREATMENT OF CANCER
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Also Published As

Publication number Publication date
CN104198709A (zh) 2014-12-10
AU2015249113B2 (en) 2017-09-07
EP2340506B1 (en) 2015-11-11
HRP20160127T1 (hr) 2016-03-11
CA2734535C (en) 2018-08-28
SI2340506T1 (sl) 2016-02-29
EP2340506A1 (en) 2011-07-06
KR20110063753A (ko) 2011-06-14
MX2011002322A (es) 2011-05-10
CN102209968B (zh) 2016-05-04
ES2559758T3 (es) 2016-02-15
CA3011730C (en) 2022-05-17
DK2340506T3 (en) 2016-02-08
CA3011730A1 (en) 2010-03-18
AU2009291811A1 (en) 2010-03-18
GB201106053D0 (en) 2011-05-25
AU2009291811B2 (en) 2015-10-29
HK1204062A1 (en) 2015-11-06
CA3152591A1 (en) 2010-03-18
GB2478441A (en) 2011-09-07
CN102209968A (zh) 2011-10-05
EP2340506A4 (en) 2012-02-15
JP5701212B2 (ja) 2015-04-15
GB2478441B (en) 2013-03-27
AU2015249113A1 (en) 2015-11-12
CA2734535A1 (en) 2010-03-18
WO2010030697A1 (en) 2010-03-18
JP2012502281A (ja) 2012-01-26
HK1153834A1 (en) 2012-04-05
KR101658347B1 (ko) 2016-09-21

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