CA3138367A1 - Methods for preparing analytes and related kits - Google Patents

Methods for preparing analytes and related kits Download PDF

Info

Publication number
CA3138367A1
CA3138367A1 CA3138367A CA3138367A CA3138367A1 CA 3138367 A1 CA3138367 A1 CA 3138367A1 CA 3138367 A CA3138367 A CA 3138367A CA 3138367 A CA3138367 A CA 3138367A CA 3138367 A1 CA3138367 A1 CA 3138367A1
Authority
CA
Canada
Prior art keywords
nucleic acid
analyte
bait
capture
solid support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3138367A
Other languages
English (en)
French (fr)
Inventor
Mark S. Chee
Kevin L. Gunderson
Norihito MURANAKA
Brian T. WEINERT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Encodia Inc
Original Assignee
Encodia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Encodia Inc filed Critical Encodia Inc
Publication of CA3138367A1 publication Critical patent/CA3138367A1/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1065Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1093General methods of preparing gene libraries, not provided for in other subgroups

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA3138367A 2019-04-30 2020-04-10 Methods for preparing analytes and related kits Pending CA3138367A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962840675P 2019-04-30 2019-04-30
US62/840,675 2019-04-30
PCT/US2020/027840 WO2020223000A1 (en) 2019-04-30 2020-04-10 Methods for preparing analytes and related kits

Publications (1)

Publication Number Publication Date
CA3138367A1 true CA3138367A1 (en) 2020-11-05

Family

ID=73029247

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3138367A Pending CA3138367A1 (en) 2019-04-30 2020-04-10 Methods for preparing analytes and related kits

Country Status (7)

Country Link
US (2) US11634709B2 (https=)
EP (1) EP3963070A4 (https=)
JP (1) JP7582676B2 (https=)
CN (1) CN114072499B (https=)
AU (1) AU2020267119A1 (https=)
CA (1) CA3138367A1 (https=)
WO (1) WO2020223000A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7390027B2 (ja) 2017-10-31 2023-12-01 エンコディア, インコーポレイテッド 核酸エンコーディングおよび/または標識を使用する解析のためのキット
CN114072499B (zh) 2019-04-30 2024-08-06 Encodia公司 用于制备分析物的方法和相关试剂盒
WO2021141924A1 (en) 2020-01-07 2021-07-15 Encodia, Inc. Methods for stable complex formation and related kits
EP4196581B1 (en) 2020-08-19 2026-02-25 Encodia, Inc. Sequential encoding methods and related kits
WO2022094148A1 (en) 2020-10-30 2022-05-05 Encodia, Inc. Conjugation reagents and methods using 1,2-cyclohexanediones
US12474346B2 (en) 2021-11-05 2025-11-18 Encodia, Inc. Methods and kits for multicycle encoding assay
EP4430206A1 (en) 2021-11-10 2024-09-18 Encodia, Inc. Methods for barcoding macromolecules in individual cells
US12043862B2 (en) 2021-12-28 2024-07-23 Encodia, Inc. High-throughput serotyping and antibody profiling assays
US20240003886A1 (en) * 2022-06-15 2024-01-04 Quantum-Si Incorporated Directed protein evolution
EP4565882A1 (en) 2022-08-02 2025-06-11 Glyphic Biotechnologies, Inc. Protein sequencing via coupling of polymerizable molecules
WO2026002230A1 (en) * 2024-06-28 2026-01-02 Syncell (Taiwan) Inc. Kits for biotin-streptavidin pulldown system and method

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863870A (en) 1988-03-10 1989-09-05 Bio-Affinity Systems, Inc. Method of thioacylation peptide sequencing with alcoholysis of thiazolinones
US5049507A (en) 1989-12-21 1991-09-17 Applied Biosystems, Inc. Method of C-terminal peptide sequencing
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
CA2176414A1 (en) 1995-05-18 1996-11-19 S. David Kimball Acyl guanidine and amidine prodrugs
WO1997005900A1 (en) 1995-08-03 1997-02-20 Rijksuniversiteit Te Leiden Cell derived antigen presenting vesicles
US5770365A (en) 1995-08-25 1998-06-23 Tm Technologies, Inc. Nucleic acid capture moieties
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US6306588B1 (en) 1997-02-07 2001-10-23 Invitrogen Corporation Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof
CA2323638A1 (en) 1998-04-03 1999-10-14 Phylos, Inc. Addressable protein arrays
US6875851B1 (en) 1999-03-05 2005-04-05 University Of Georgia Research Foundation, Inc. Prolyl tripeptidyl peptidases nucleic acid of Porphyromonas gingivalis
WO2000057183A1 (en) 1999-03-23 2000-09-28 Biovation Limited Protein isolation and analysis
AU5723700A (en) 1999-05-25 2000-12-12 Praelux Incorporated Method for sequency and characterizing polymeric biomolecules using aptamers anda method for producing aptamers
GB9927320D0 (en) 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US7306904B2 (en) 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
AU2001241939A1 (en) * 2000-02-28 2001-09-12 Maxygen, Inc. Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation
US6511809B2 (en) * 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
CA2314398A1 (en) 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
US20030087232A1 (en) 2001-01-25 2003-05-08 Fred Christians Methods for screening polypeptides
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
US7169894B2 (en) 2001-11-14 2007-01-30 Mirari Biosciences, Inc. Methods and compositions for reverse translation
JP2005509444A (ja) 2001-11-23 2005-04-14 シモン・フレデリックソン 多価近接プローブにより近接プロービングするための方法およびキット
MX282672B (es) 2002-10-10 2011-01-10 Diversa Corp Proteasas, acidos nucleicos que los codifican, y metodos de hacer y usar los mismos.
US20090246879A1 (en) 2002-12-20 2009-10-01 Callida Genomics Materials and Methods Relating to Nano-Tags and Nano-Brands
WO2005015239A2 (en) 2003-08-07 2005-02-17 Cornell Research Foundation, Inc. Method for n-terminal labeling of proteins
US7198900B2 (en) 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
US11118215B2 (en) 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
US7579165B2 (en) 2003-10-16 2009-08-25 Shimadzu Corporation Methods for derivatizing protein or peptide with sulfonic acid groups
GB0326073D0 (en) * 2003-11-07 2003-12-10 Solexa Ltd Improvements in or relating to polynucleotide arrays
EP1694693A2 (en) 2003-12-17 2006-08-30 Praecis Pharmaceuticals Inc. Methods for synthesis of encoded libraries
GB0404187D0 (en) 2004-02-25 2004-03-31 Biotransformations Ltd Binding agents
DE602005017370D1 (de) 2004-03-22 2009-12-10 Nuevolution As Ligationscodierung unter verwendung von oligonukleotidbausteinen
CN1296492C (zh) * 2004-11-18 2007-01-24 博奥生物有限公司 一种基于生物芯片检测能结合特异序列的核酸结合蛋白的方法
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US20060199279A1 (en) 2005-03-07 2006-09-07 Viorica Lopez-Avila Methods for identifying post-translationally modified polypeptides
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
JP2009505106A (ja) * 2005-08-19 2009-02-05 ナノスフェアー インコーポレイテッド Dna及び抗体を含むハイブリッド基板を調製するための方法及びその使用
US7611834B2 (en) 2005-09-30 2009-11-03 Sandia Corporation Methods and devices for protein assays
PT3305900T (pt) 2005-12-01 2021-10-27 Nuevolution As Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes
US20070218503A1 (en) 2006-02-13 2007-09-20 Mitra Robi D Methods of polypeptide identification, and compositions therefor
DE102006015001A1 (de) 2006-03-31 2007-10-11 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Verfahren zum Nachweis und/oder zur Anreicherung von Analytproteinen und/oder Analytpeptiden aus einer komplexen Proteinmischung
WO2007127848A1 (en) 2006-04-26 2007-11-08 University Of Louisville Research Foundation, Inc Isolation of membrane vesicles from biological fluids and methods of using same
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US20110136099A1 (en) * 2007-01-16 2011-06-09 Somalogic, Inc. Multiplexed Analyses of Test Samples
WO2008115556A2 (en) * 2007-03-19 2008-09-25 Cold Spring Harbor Laboratory Identification of genetic alterations that modulate drug sensitivity in cancer treatments
CN101849021A (zh) * 2007-06-14 2010-09-29 浦项工科大学校产学协力团 作为用于生物芯片的分析工具的原子力显微镜
WO2009019215A1 (en) 2007-08-03 2009-02-12 Dkfz Deutsches Krebsforschungszentrum Method for prenatal diagnosis using exosomes and cd24 as a marker
US20100311114A1 (en) 2007-10-19 2010-12-09 Pronota N.V. Preparation of samples for proteome analysis
WO2010065531A1 (en) 2008-12-01 2010-06-10 Robi David Mitra Single molecule protein screening
CA2745197A1 (en) 2008-12-01 2010-06-10 Research Triangle Institute Concurrent identification of multitudes of polypeptides
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US9566335B1 (en) 2009-09-25 2017-02-14 The Governing Council Of The University Of Toronto Protein sequencing method and reagents
WO2011056185A2 (en) 2009-11-04 2011-05-12 President And Fellows Of Harvard College Reactivity-dependent and interaction-dependent pcr
WO2011127099A1 (en) 2010-04-05 2011-10-13 Prognosys Biosciences, Inc. Spatially encoded biological assays
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
US20130059741A1 (en) 2010-05-13 2013-03-07 Illumina, Inc. Binding assays for markers
WO2012041633A1 (en) 2010-09-27 2012-04-05 Vipergen A method for making an enriched library
CA2817111C (en) 2010-11-10 2019-03-05 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
ES2986436T3 (es) 2011-04-15 2024-11-11 Univ Johns Hopkins Sistema de secuenciación segura
CA2835641C (en) 2011-05-11 2019-05-28 Exosome Diagnostics, Inc. Nucleic acid extraction from heterogeneous biological materials
CA2839702C (en) 2011-06-23 2021-04-20 Board Of Regents, The University Of Texas System Identifying peptides at the single molecule level
EP3492606B1 (en) 2011-08-22 2023-10-04 Exosome Diagnostics, Inc. Urine biomarkers
US20130052665A1 (en) 2011-08-25 2013-02-28 Bruce Xuefeng Ling Methods for diagnosis of systemic juvenile idiopathic arthritis
US9335292B2 (en) 2011-10-13 2016-05-10 Auburn University Electrochemical proximity assay
US10174361B2 (en) 2011-11-10 2019-01-08 Exosome Diagnostics, Inc. Cerebrospinal fluid assay
US20150087526A1 (en) 2012-01-24 2015-03-26 The Regents Of The University Of Colorado, A Body Corporate Peptide identification and sequencing by single-molecule detection of peptides undergoing degradation
WO2013123442A1 (en) 2012-02-17 2013-08-22 Fred Hutchinson Cancer Research Center Compositions and methods for accurately identifying mutations
WO2013138510A1 (en) 2012-03-13 2013-09-19 Patel Abhijit Ajit Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
PT2828218T (pt) 2012-03-20 2020-11-11 Univ Washington Through Its Center For Commercialization Métodos para baixar a taxa de erro da sequenciação paralela massiva de adn utilizando sequenciação duplex de consensus
US9005888B2 (en) 2012-06-14 2015-04-14 System Biosciences, Llc Methods for microvesicle isolation and selective removal
NL2009191C2 (en) 2012-07-16 2014-01-20 Univ Delft Tech Single molecule protein sequencing.
US20140378322A1 (en) 2012-08-14 2014-12-25 10X Technologies, Inc. Compositions and methods for sample processing
WO2014055775A1 (en) 2012-10-03 2014-04-10 Exosome Diagnostics, Inc. Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions
EP4170031A1 (en) 2012-10-23 2023-04-26 Caris Science, Inc. Aptamers and uses thereof
WO2014142981A1 (en) 2013-03-15 2014-09-18 Illumina, Inc. Enzyme-linked nucleotides
US9435810B2 (en) 2013-03-15 2016-09-06 Washington University Molecules and methods for iterative polypeptide analysis and processing
US10053725B2 (en) 2013-04-23 2018-08-21 President And Fellows Of Harvard College In situ interaction determination
CA2916662C (en) 2013-06-25 2022-03-08 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
CN105980615A (zh) 2013-08-28 2016-09-28 卡里斯生命科学瑞士控股有限公司 寡核苷酸探针及其用途
US10466248B2 (en) 2013-09-23 2019-11-05 The Trustees Of Columbia University In The City Of New York High-throughput single molecule protein identification
CN106030304B (zh) 2014-02-27 2018-02-06 得克萨斯大学体系董事会 用于分离外来体的方法和组合物
US10858698B2 (en) 2014-03-25 2020-12-08 President And Fellows Of Harvard College Barcoded protein array for multiplex single-molecule interaction profiling
AU2015250034B2 (en) 2014-04-21 2019-06-20 President And Fellows Of Harvard College Systems and methods for barcoding nucleic acids
WO2015163818A1 (en) 2014-04-24 2015-10-29 Nanyang Technological University Asx-specific protein ligase
WO2015166768A1 (ja) 2014-05-02 2015-11-05 国立大学法人金沢大学 単一細胞由来核酸の解析方法
WO2015176034A1 (en) 2014-05-15 2015-11-19 Two Pore Guys, Inc. Scaffold data storage and target detection in a sample using a nanopore
CA2953469A1 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Analysis of nucleic acid sequences
WO2015200893A2 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
US11229607B2 (en) 2014-06-30 2022-01-25 President And Fellows Of Harvard College Hydrogel compositions comprising encapsulated cells and methods of use thereof
CA3084920C (en) 2014-07-09 2023-02-28 Exosome Diagnostics, Inc. Methods for isolating microvesicles and extracting nucleic acids from biological samples
US10526641B2 (en) 2014-08-01 2020-01-07 Dovetail Genomics, Llc Tagging nucleic acids for sequence assembly
CA3208970A1 (en) 2014-09-15 2016-05-06 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
RU2736728C2 (ru) 2014-10-17 2020-11-19 Иллумина Кембридж Лимитед Транспозиция с сохранением сцепления генов
US9771412B2 (en) 2014-10-31 2017-09-26 Wisconsin Alumni Research Foundation Engineered intein for improved production of protein-intein fusions
KR102699584B1 (ko) * 2015-02-02 2024-08-28 메이라지티엑스 유케이 Ii 리미티드 대안적 스플라이싱의 압타머 매개 조절에 의한 유전자 발현 제어
CN107406890B (zh) 2015-02-10 2023-07-18 亿明达股份有限公司 用于分析细胞组分的方法和组合物
WO2016138496A1 (en) 2015-02-27 2016-09-01 Cellular Research, Inc. Spatially addressable molecular barcoding
WO2016145416A2 (en) 2015-03-11 2016-09-15 The Broad Institute, Inc. Proteomic analysis with nucleic acid identifiers
WO2016164530A1 (en) 2015-04-07 2016-10-13 University Of Maryland, College Park Compositions and methods for high throughput protein sequencing
CA2988771A1 (en) 2015-06-09 2016-12-15 The Board Of Regents Of The University Of Texas System Diagnostic test for early stage cancer
EP3387128A4 (en) * 2015-12-07 2019-12-04 Bio-Rad Laboratories, Inc. MULTIPLEXING IN PARTITIONS ON THE BASIS OF MICROPARTICLES
EP4239079B1 (en) 2016-02-17 2025-12-17 President And Fellows Of Harvard College Molecular programming tools
EP3452591B1 (en) * 2016-05-02 2023-08-16 Encodia, Inc. Macromolecule analysis employing nucleic acid encoding
EP4108781A1 (en) 2016-05-27 2022-12-28 President and Fellows of Harvard College Conditional primer extension for single-molecule detection
WO2018005720A1 (en) 2016-06-30 2018-01-04 President And Fellows Of Harvard College Method of determining the molecular binding between libraries of molecules
FR3054039B1 (fr) * 2016-07-12 2020-05-29 Universite De Montpellier Biocapteur pour detecter la presence de bacteries
WO2018017914A1 (en) 2016-07-22 2018-01-25 President And Fellows Of Harvard College Methods and compositions for protein identification
GB201616313D0 (en) * 2016-09-26 2016-11-09 Oslo Universitetssykehus Hf And Universitetet I Oslo Method
EP4029939B1 (en) 2017-01-30 2023-06-28 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
CN117887804A (zh) 2017-02-02 2024-04-16 纽约基因组研究中心公司 用于识别或量化在生物样品中的靶标的方法和组合物
US11072816B2 (en) * 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers
JP7390027B2 (ja) 2017-10-31 2023-12-01 エンコディア, インコーポレイテッド 核酸エンコーディングおよび/または標識を使用する解析のためのキット
SG11202003923PA (en) 2017-10-31 2020-05-28 Encodia Inc Methods and kits using nucleic acid encoding and/or label
CA3081446A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Methods and compositions for polypeptide analysis
KR20250152680A (ko) 2017-12-29 2025-10-23 노틸러스 서브시디어리, 인크. 단백질 식별을 위한 디코딩 접근법
EP3740567A4 (en) 2018-01-18 2022-03-09 Nanosomix Inc. DETECTION OF EXOSOMES AND EXOSOMAL BIOMARKERS FOR DIAGNOSIS AND PROGNOSIS OF DISEASES AND DISORDERS
US12270741B2 (en) 2018-04-03 2025-04-08 Tymora Analytical Operations, Llc Methods for affinity-based non-antibody capture and purification of extracellular vesicles
EP3775196A4 (en) * 2018-04-04 2021-12-22 Nautilus Biotechnology, Inc. METHOD FOR GENERATING NANOARRAYS AND MICROARRAYS
JP7590955B2 (ja) * 2018-08-17 2024-11-27 ベクトン・ディキンソン・アンド・カンパニー アプタマーバーコーディング
US11549135B2 (en) * 2018-09-14 2023-01-10 The Broad Institute, Inc. Oligonucleotide-coupled antibodies for single cell or single complex protein measurements
US11078480B2 (en) * 2018-09-19 2021-08-03 California Institute Of Technology High-throughput identification of intermolecular interactions
CN114072499B (zh) 2019-04-30 2024-08-06 Encodia公司 用于制备分析物的方法和相关试剂盒

Also Published As

Publication number Publication date
US11634709B2 (en) 2023-04-25
CN114072499B (zh) 2024-08-06
AU2020267119A1 (en) 2021-11-18
CN114072499A (zh) 2022-02-18
US20230279386A1 (en) 2023-09-07
EP3963070A4 (en) 2023-02-22
US20220049246A1 (en) 2022-02-17
EP3963070A1 (en) 2022-03-09
JP2022530966A (ja) 2022-07-05
WO2020223000A1 (en) 2020-11-05
JP7582676B2 (ja) 2024-11-13

Similar Documents

Publication Publication Date Title
US11634709B2 (en) Methods for preparing analytes and related kits
JP7333975B2 (ja) 核酸エンコーディングを使用した巨大分子解析
KR102567902B1 (ko) 변형된 클리바아제, 이의 용도 및 관련 키트
KR20200093557A (ko) 핵산 암호화 및/또는 표지를 이용한 분석용 키트
US11169157B2 (en) Methods for stable complex formation and related kits
EP4196581B1 (en) Sequential encoding methods and related kits
WO2020154208A1 (en) Methods and compositions of accelerating reactions for polypeptide analysis and related uses
US20220214350A1 (en) Methods for stable complex formation and related kits
WO2021141922A1 (en) Methods for information transfer and related kits
AU2021329812B2 (en) Sequential encoding methods and related kits
CA3134776C (en) Modified cleavases, uses thereof and related kits
WO2021141924A1 (en) Methods for stable complex formation and related kits

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20220907

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20241031

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION

Effective date: 20250227

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20250228

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD

Year of fee payment: 5

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250404

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250404

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20250612

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20250612

R00 Party data change recorded

Free format text: ST27 STATUS EVENT CODE: A-2-2-R10-R00-R119 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REVOCATION OF AGENT REQUEST

Effective date: 20260220

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20260220

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD

Year of fee payment: 6

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20260402

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20260402