CA3136737A1 - Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods - Google Patents

Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods Download PDF

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Publication number
CA3136737A1
CA3136737A1 CA3136737A CA3136737A CA3136737A1 CA 3136737 A1 CA3136737 A1 CA 3136737A1 CA 3136737 A CA3136737 A CA 3136737A CA 3136737 A CA3136737 A CA 3136737A CA 3136737 A1 CA3136737 A1 CA 3136737A1
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Prior art keywords
cell
sequence
receptor
domain
tgfbr2
Prior art date
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Pending
Application number
CA3136737A
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English (en)
French (fr)
Inventor
Stephen Michael BURLEIGH
Cedric CLEYRAT
Melissa CHIN
Fred HARBINSKI
Christopher Heath NYE
Blythe D. SATHER
Queenie VONG
G. Grant Welstead
Christopher Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Juno Therapeutics Inc
Editas Medicine Inc
Original Assignee
Juno Therapeutics Inc
Editas Medicine Inc
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Application filed by Juno Therapeutics Inc, Editas Medicine Inc filed Critical Juno Therapeutics Inc
Publication of CA3136737A1 publication Critical patent/CA3136737A1/en
Pending legal-status Critical Current

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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CA3136737A 2019-05-01 2020-04-30 Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods Pending CA3136737A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962841575P 2019-05-01 2019-05-01
US62/841,575 2019-05-01
PCT/US2020/030815 WO2020223535A1 (en) 2019-05-01 2020-04-30 Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods

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CA3136737A1 true CA3136737A1 (en) 2020-11-05

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US (1) US20220184131A1 (https=)
EP (1) EP3962520A1 (https=)
JP (1) JP2022531222A (https=)
KR (1) KR20220016475A (https=)
CN (1) CN114025788A (https=)
AU (1) AU2020265741A1 (https=)
BR (1) BR112021021075A2 (https=)
CA (1) CA3136737A1 (https=)
IL (1) IL287207A (https=)
MA (1) MA55811A (https=)
MX (1) MX2021013219A (https=)
SG (1) SG11202111360YA (https=)
WO (1) WO2020223535A1 (https=)

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WO2020231882A2 (en) 2019-05-10 2020-11-19 The Regents Of The University Of California Modified pluripotent cells
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
EP4313087A4 (en) * 2021-03-30 2025-03-19 The Regents of the University of California PROTECTION OF TRANSPLANTED CELLS VIA MODIFIED FC RECEPTORS
WO2022232277A1 (en) * 2021-04-27 2022-11-03 TCR2 Therapeutics Inc. COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS AND TGFβR SWITCH
WO2022232840A1 (en) * 2021-04-29 2022-11-03 The Regents Of The University Of California Systems and methods for genetic editing with increased efficiency
EP4355879A4 (en) * 2021-06-14 2025-07-23 Kamau Therapeutics Inc METHODS FOR GENETIC MODIFICATION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS FOR ERYTHROCYTE-SPECIFIC EXPRESSION OF THERAPEUTIC PROTEINS
WO2023007373A1 (en) * 2021-07-26 2023-02-02 Crispr Therapeutics Ag Methods for manufacturing genetically engineered car-t cells
WO2023010436A1 (zh) * 2021-08-05 2023-02-09 卡瑞济(北京)生命科技有限公司 Tcr表达构建体以及其制备方法和用途
CN115918611B (zh) * 2021-10-25 2025-06-27 百奥赛图(北京)医药科技股份有限公司 Tgfbr2基因人源化非人动物及其构建方法和应用
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