CA3134271A1 - Compositions and methods comprising a ttr guide rna and a polynucleotide encoding an rna-guided dna binding agent - Google Patents

Compositions and methods comprising a ttr guide rna and a polynucleotide encoding an rna-guided dna binding agent Download PDF

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Publication number
CA3134271A1
CA3134271A1 CA3134271A CA3134271A CA3134271A1 CA 3134271 A1 CA3134271 A1 CA 3134271A1 CA 3134271 A CA3134271 A CA 3134271A CA 3134271 A CA3134271 A CA 3134271A CA 3134271 A1 CA3134271 A1 CA 3134271A1
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Prior art keywords
composition
lipid
seq
ttr
rna
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CA3134271A
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English (en)
French (fr)
Inventor
Yong Chang
Seth C. Alexander
Kristy M. WOOD
Arti Mahendra Prakash KANJOLIA
Shobu ODATE
Jessica Lynn SEITZER
Reynald Michael LESCARBEAU
Walter Strapps
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Intellia Therapeutics Inc
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Intellia Therapeutics Inc
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Publication of CA3134271A1 publication Critical patent/CA3134271A1/en
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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CA3134271A 2019-03-28 2020-03-27 Compositions and methods comprising a ttr guide rna and a polynucleotide encoding an rna-guided dna binding agent Pending CA3134271A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962825637P 2019-03-28 2019-03-28
US62/825,637 2019-03-28
PCT/US2020/025513 WO2020198697A1 (en) 2019-03-28 2020-03-27 Compositions and methods comprising a ttr guide rna and a polynucleotide encoding an rna-guided dna binding agent

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CA3134271A1 true CA3134271A1 (en) 2020-10-01

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CA3134271A Pending CA3134271A1 (en) 2019-03-28 2020-03-27 Compositions and methods comprising a ttr guide rna and a polynucleotide encoding an rna-guided dna binding agent

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US (3) US20230044994A1 (enExample)
EP (1) EP3946598A1 (enExample)
JP (2) JP7631215B2 (enExample)
KR (1) KR20220004648A (enExample)
CN (1) CN113874076A (enExample)
AU (1) AU2020244887A1 (enExample)
BR (1) BR112021019196A2 (enExample)
CA (1) CA3134271A1 (enExample)
CO (1) CO2021014559A2 (enExample)
EA (1) EA202192636A1 (enExample)
IL (1) IL286524A (enExample)
MX (1) MX2021011565A (enExample)
PH (1) PH12021552301A1 (enExample)
SG (1) SG11202110434PA (enExample)
WO (1) WO2020198697A1 (enExample)

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