AU2020244887A1 - Compositions and methods comprising a TTR guide RNA and a polynucleotide encoding an RNA-guided DNA binding agent - Google Patents

Compositions and methods comprising a TTR guide RNA and a polynucleotide encoding an RNA-guided DNA binding agent Download PDF

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Publication number
AU2020244887A1
AU2020244887A1 AU2020244887A AU2020244887A AU2020244887A1 AU 2020244887 A1 AU2020244887 A1 AU 2020244887A1 AU 2020244887 A AU2020244887 A AU 2020244887A AU 2020244887 A AU2020244887 A AU 2020244887A AU 2020244887 A1 AU2020244887 A1 AU 2020244887A1
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lipid
composition
seq
mol
rna
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AU2020244887A
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Inventor
Seth C. Alexander
Yong Chang
Arti Mahendra Prakash KANJOLIA
Reynald Michael LESCARBEAU
Shobu ODATE
Jessica Lynn SEITZER
Walter Strapps
Kristy M. WOOD
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Intellia Therapeutics Inc
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Intellia Therapeutics Inc
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Publication of AU2020244887A1 publication Critical patent/AU2020244887A1/en
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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AU2020244887A 2019-03-28 2020-03-27 Compositions and methods comprising a TTR guide RNA and a polynucleotide encoding an RNA-guided DNA binding agent Pending AU2020244887A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962825637P 2019-03-28 2019-03-28
US62/825,637 2019-03-28
PCT/US2020/025513 WO2020198697A1 (en) 2019-03-28 2020-03-27 Compositions and methods comprising a ttr guide rna and a polynucleotide encoding an rna-guided dna binding agent

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AU2020244887A1 true AU2020244887A1 (en) 2021-11-11

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US (2) US20230044994A1 (enExample)
EP (1) EP3946598A1 (enExample)
JP (2) JP7631215B2 (enExample)
KR (1) KR20220004648A (enExample)
CN (1) CN113874076A (enExample)
AU (1) AU2020244887A1 (enExample)
BR (1) BR112021019196A2 (enExample)
CA (1) CA3134271A1 (enExample)
CO (1) CO2021014559A2 (enExample)
EA (1) EA202192636A1 (enExample)
IL (1) IL286524A (enExample)
MX (1) MX2021011565A (enExample)
PH (1) PH12021552301A1 (enExample)
SG (1) SG11202110434PA (enExample)
WO (1) WO2020198697A1 (enExample)

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WO2023185697A2 (en) 2022-03-29 2023-10-05 Accuredit Therapeutics (Suzhou) Co., Ltd. Compositions and methods for treatment of transthyretin amyloidosis
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WO2024061296A2 (en) 2022-09-22 2024-03-28 Accuredit Therapeutics (Suzhou) Co., Ltd. Compositions and methods for treatment of hypercholesterolemia and/or cardiovascular disease
EP4627083A1 (en) * 2022-11-30 2025-10-08 Arbor Biotechnologies, Inc. Reverse transcriptase-mediated genetic editing of transthyretin (ttr) and uses thereof
WO2025128871A2 (en) 2023-12-13 2025-06-19 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents

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JP7631215B2 (ja) 2025-02-18
JP2022525428A (ja) 2022-05-13
MX2021011565A (es) 2021-11-12
PH12021552301A1 (en) 2022-07-04
WO2020198697A1 (en) 2020-10-01
IL286524A (en) 2021-10-31
US20230044994A1 (en) 2023-02-09
JP2025072483A (ja) 2025-05-09
CN113874076A (zh) 2021-12-31
CA3134271A1 (en) 2020-10-01
CO2021014559A2 (es) 2021-11-19
SG11202110434PA (en) 2021-10-28
BR112021019196A2 (pt) 2022-01-18
EA202192636A1 (ru) 2022-03-17
US20240124897A1 (en) 2024-04-18
KR20220004648A (ko) 2022-01-11
EP3946598A1 (en) 2022-02-09

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