CA3120695A1 - Mononuclear cell derived nk cells - Google Patents
Mononuclear cell derived nk cells Download PDFInfo
- Publication number
- CA3120695A1 CA3120695A1 CA3120695A CA3120695A CA3120695A1 CA 3120695 A1 CA3120695 A1 CA 3120695A1 CA 3120695 A CA3120695 A CA 3120695A CA 3120695 A CA3120695 A CA 3120695A CA 3120695 A1 CA3120695 A1 CA 3120695A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- mixture
- antibody
- mononuclear
- activated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000822 natural killer cell Anatomy 0.000 title claims abstract description 106
- 210000005087 mononuclear cell Anatomy 0.000 title claims abstract description 64
- 238000000034 method Methods 0.000 claims abstract description 93
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- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
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- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 2
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- 230000006051 NK cell activation Effects 0.000 description 2
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- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
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- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 description 1
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 description 1
- 102100021462 Natural killer cells antigen CD94 Human genes 0.000 description 1
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- 238000000684 flow cytometry Methods 0.000 description 1
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- 210000002865 immune cell Anatomy 0.000 description 1
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- 229940079322 interferon Drugs 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
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- 210000004698 lymphocyte Anatomy 0.000 description 1
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- 229930192851 perforin Natural products 0.000 description 1
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- 210000004976 peripheral blood cell Anatomy 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2019/040867 WO2021006875A1 (en) | 2019-07-08 | 2019-07-08 | Mononuclear cell derived nk cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3120695A1 true CA3120695A1 (en) | 2021-01-14 |
Family
ID=74114919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3120695A Pending CA3120695A1 (en) | 2019-07-08 | 2019-07-08 | Mononuclear cell derived nk cells |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP3853354A4 (ja) |
| JP (2) | JP7213976B2 (ja) |
| KR (1) | KR20210080566A (ja) |
| CN (1) | CN113166726A (ja) |
| AU (1) | AU2019456283B2 (ja) |
| CA (1) | CA3120695A1 (ja) |
| IL (1) | IL283998A (ja) |
| SG (1) | SG11202104339WA (ja) |
| WO (1) | WO2021006875A1 (ja) |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2411507T (pt) * | 2009-03-26 | 2020-01-09 | Cellprotect Nordic Pharmaceuticals Ab | Expansão de células nk |
| KR20210120136A (ko) | 2009-12-04 | 2021-10-06 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 인간 배아줄기세포 유래된 혈액모세포로부터 자연 살해 세포 및 수지상 세포를 생성하는 방법 |
| EP2539442A1 (en) | 2010-02-24 | 2013-01-02 | Ingo Schmidt-Wolf | Method for the generation of a cik cell and nk cell population |
| KR102070098B1 (ko) | 2010-09-21 | 2020-01-28 | 알토 바이오사이언스 코포레이션 | 다량체성 아이엘 15 용해성 융합 분자 및 그의 제조 및 사용 방법 |
| US20130295671A1 (en) | 2011-01-21 | 2013-11-07 | Biotherapy Institute Of Japan | Method for producing nk cell-enriched blood preparation |
| ES2856825T3 (es) | 2011-03-18 | 2021-09-28 | Glycostem Therapeutics B V | Generación de células NK y progenitores de células NK |
| WO2013119118A1 (en) | 2012-02-08 | 2013-08-15 | Ipd-Therapeutics B.V. | Ex vivo nk cell differentiation from cd34+ hematopoietic cells |
| CN102988415B (zh) | 2012-08-15 | 2014-11-19 | 中航（宁夏）生物有限责任公司 | 人异基因有核细胞工业化制备自然杀伤性细胞(nk)及注射液 |
| WO2015154012A1 (en) * | 2014-04-03 | 2015-10-08 | Memorial Sloan-Kettering Cancer Center | Clonogenic natural killer (nk) cell populations and methods of producing and using such populations |
| WO2015165700A1 (en) | 2014-04-28 | 2015-11-05 | Vivabiocell Spa | Automated cell culturing and harvesting device |
| KR101683614B1 (ko) * | 2016-02-15 | 2016-12-07 | 신동혁 | Nk세포배양용 배지첨가키트 및 상기 키트를 이용한 nk세포배양방법 |
| EP3515471A4 (en) * | 2016-09-23 | 2020-07-01 | The Regents of The University of California | SELF-MODIFIED LENTIVIRAL-MODIFIED IRRADIATED WHOLE CELL ANTI-TUMOR VACCINES TO EXPRESS CD80, IL-15 AND THE IL-15 ALPHA RECEPTOR |
| RU2019114175A (ru) | 2016-10-14 | 2020-11-16 | Ксенкор, Инк. | Биспецифические гетеродимерные слитые белки, содержащие fc-слитые белки il-15/il-15ra и фрагменты антитела к pd-1 |
| WO2018158350A1 (en) * | 2017-02-28 | 2018-09-07 | Affimed Gmbh | Combination of an anti-cd16a antibody with a cytokine |
| AU2018231170B2 (en) | 2017-03-06 | 2020-07-16 | Altor Bioscience Corporation | IL-15-based fusions to IL-12 and IL-18 |
| WO2018209208A1 (en) * | 2017-05-11 | 2018-11-15 | Nantkwest, Inc. | Anti-egfr/high affinity nk-cells compositions and methods for chordoma treatment |
| US12060577B2 (en) * | 2017-05-19 | 2024-08-13 | Case Western Reserve University | Compositions for expanding natural killer cells |
| CN108070556A (zh) * | 2017-07-26 | 2018-05-25 | 深圳市北科生物科技有限公司 | 用于免疫细胞培养的方法和组合物 |
| CA3074635A1 (en) * | 2017-08-28 | 2019-03-07 | Altor Bioscience Llc | Il-15-based fusions to il-7 and il-21 |
-
2019
- 2019-07-08 WO PCT/US2019/040867 patent/WO2021006875A1/en unknown
- 2019-07-08 CN CN201980078702.2A patent/CN113166726A/zh active Pending
- 2019-07-08 EP EP19936966.1A patent/EP3853354A4/en active Pending
- 2019-07-08 KR KR1020217018216A patent/KR20210080566A/ko not_active Application Discontinuation
- 2019-07-08 CA CA3120695A patent/CA3120695A1/en active Pending
- 2019-07-08 SG SG11202104339WA patent/SG11202104339WA/en unknown
- 2019-07-08 JP JP2021527968A patent/JP7213976B2/ja active Active
- 2019-07-08 AU AU2019456283A patent/AU2019456283B2/en active Active
-
2021
- 2021-06-14 IL IL283998A patent/IL283998A/en unknown
-
2023
- 2023-01-10 JP JP2023001780A patent/JP2023040184A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL283998A (en) | 2021-07-29 |
| CN113166726A (zh) | 2021-07-23 |
| WO2021006875A1 (en) | 2021-01-14 |
| EP3853354A1 (en) | 2021-07-28 |
| EP3853354A4 (en) | 2022-04-20 |
| JP2023040184A (ja) | 2023-03-22 |
| JP2022513614A (ja) | 2022-02-09 |
| AU2019456283B2 (en) | 2023-06-08 |
| AU2019456283A1 (en) | 2021-05-20 |
| KR20210080566A (ko) | 2021-06-30 |
| JP7213976B2 (ja) | 2023-01-27 |
| SG11202104339WA (en) | 2021-05-28 |
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| EEER | Examination request |
Effective date: 20210520 |