CA3109572A1 - Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them - Google Patents
Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them Download PDFInfo
- Publication number
- CA3109572A1 CA3109572A1 CA3109572A CA3109572A CA3109572A1 CA 3109572 A1 CA3109572 A1 CA 3109572A1 CA 3109572 A CA3109572 A CA 3109572A CA 3109572 A CA3109572 A CA 3109572A CA 3109572 A1 CA3109572 A1 CA 3109572A1
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- Prior art keywords
- clofazimine
- pharmaceutical composition
- composition according
- infection
- suspension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- WDQPAMHFFCXSNU-BGABXYSRSA-N clofazimine Chemical group C12=CC=CC=C2N=C2C=C(NC=3C=CC(Cl)=CC=3)C(=N/C(C)C)/C=C2N1C1=CC=C(Cl)C=C1 WDQPAMHFFCXSNU-BGABXYSRSA-N 0.000 title claims abstract description 229
- 229960004287 clofazimine Drugs 0.000 title claims abstract description 223
- 239000000203 mixture Substances 0.000 title claims abstract description 129
- 238000000034 method Methods 0.000 title claims abstract description 62
- 230000008569 process Effects 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 208000015181 infectious disease Diseases 0.000 claims abstract description 98
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 83
- 239000000725 suspension Substances 0.000 claims abstract description 66
- 238000011282 treatment Methods 0.000 claims abstract description 63
- 239000000443 aerosol Substances 0.000 claims abstract description 59
- 230000002685 pulmonary effect Effects 0.000 claims abstract description 38
- 238000011321 prophylaxis Methods 0.000 claims abstract description 32
- 208000013606 Fungal Lung disease Diseases 0.000 claims abstract description 15
- 241000192125 Firmicutes Species 0.000 claims abstract description 12
- 239000002245 particle Substances 0.000 claims description 140
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 139
- 239000011780 sodium chloride Substances 0.000 claims description 71
- 238000000265 homogenisation Methods 0.000 claims description 61
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 47
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- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
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| US201862722048P | 2018-08-23 | 2018-08-23 | |
| US62/722,048 | 2018-08-23 | ||
| US201962796822P | 2019-01-25 | 2019-01-25 | |
| US62/796,822 | 2019-01-25 | ||
| PCT/US2019/025538 WO2020040818A1 (en) | 2018-08-23 | 2019-04-03 | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
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| CA3109572A1 true CA3109572A1 (en) | 2020-02-27 |
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| CA3109572A Pending CA3109572A1 (en) | 2018-08-23 | 2019-04-03 | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
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| EP (1) | EP3840737A1 (ja) |
| JP (2) | JP7377259B2 (ja) |
| KR (1) | KR20210090607A (ja) |
| CN (1) | CN112804993A (ja) |
| AU (1) | AU2019324330A1 (ja) |
| CA (1) | CA3109572A1 (ja) |
| WO (1) | WO2020040818A1 (ja) |
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| CN114828828A (zh) * | 2019-11-06 | 2022-07-29 | 曼金德公司 | 氯法齐明的组合物，含它们的组合，它们的制备方法，含它们的用途和治疗方法 |
| CN111634940B (zh) * | 2020-05-27 | 2021-10-29 | 中国地质大学（武汉） | 一种单质金均匀负载钛酸盐纳米材料的制备方法 |
| CN112521339A (zh) * | 2020-11-20 | 2021-03-19 | 山西立业制药有限公司 | 一种氯苯吩嗪的制备方法 |
| US11793808B2 (en) * | 2021-02-22 | 2023-10-24 | Mannkind Corp. | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
| CN114507189A (zh) * | 2021-12-08 | 2022-05-17 | 余述南 | 一种化学合成的原料药及其治疗结核病及耐药性结核病的用途 |
| CN115737560A (zh) * | 2022-12-27 | 2023-03-07 | 四川农业大学 | 一种酸响应的一氧化氮/活性氧纳米发生器及其制备方法 |
| CN116283970B (zh) * | 2023-03-06 | 2024-09-06 | 贵州大学 | 水杨羰基烯拼接莫西沙星衍生物及其制备方法及应用 |
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| US3826255A (en) | 1972-06-22 | 1974-07-30 | Hudson Oxygen Therapy Sales Co | Intermittent positive pressure breathing manifold |
| YU41046B (en) | 1974-08-22 | 1986-10-31 | Schering Ag | Medicine inholating device |
| US4268460A (en) | 1977-12-12 | 1981-05-19 | Warner-Lambert Company | Nebulizer |
| US4253468A (en) | 1978-08-14 | 1981-03-03 | Steven Lehmbeck | Nebulizer attachment |
| US4263907A (en) | 1979-05-14 | 1981-04-28 | Lindsey Joseph W | Respirator nebulizer |
| US4510929A (en) | 1982-04-30 | 1985-04-16 | Bordoni Maurice E | Disposable radioactive aerosol inhalation apparatus |
| US4649911A (en) | 1983-09-08 | 1987-03-17 | Baylor College Of Medicine | Small particle aerosol generator for treatment of respiratory disease including the lungs |
| US4624251A (en) | 1984-09-13 | 1986-11-25 | Riker Laboratories, Inc. | Apparatus for administering a nebulized substance |
| US5164740A (en) | 1991-04-24 | 1992-11-17 | Yehuda Ivri | High frequency printing mechanism |
| EP0540775B1 (de) | 1991-11-07 | 1997-07-23 | PAUL RITZAU PARI-WERK GmbH | Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie |
| US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
| US5558085A (en) | 1993-01-29 | 1996-09-24 | Aradigm Corporation | Intrapulmonary delivery of peptide drugs |
| US5709202A (en) | 1993-05-21 | 1998-01-20 | Aradigm Corporation | Intrapulmonary delivery of aerosolized formulations |
| AU4990696A (en) | 1995-02-24 | 1996-09-11 | Nanosystems L.L.C. | Aerosols containing nanoparticle dispersions |
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| US6083922A (en) | 1996-04-02 | 2000-07-04 | Pathogenesis, Corp. | Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis |
| US5906202A (en) | 1996-11-21 | 1999-05-25 | Aradigm Corporation | Device and method for directing aerosolized mist to a specific area of the respiratory tract |
| US6349719B2 (en) | 1997-02-24 | 2002-02-26 | Aradigm Corporation | Formulation and devices for monitoring the efficacy of the delivery of aerosols |
| US5855564A (en) | 1997-08-20 | 1999-01-05 | Aradigm Corporation | Aerosol extrusion mechanism |
| WO1999017754A1 (en) | 1997-10-08 | 1999-04-15 | Sepracor Inc. | Dosage form for aerosol administration |
| DE1129741T1 (de) | 1997-11-19 | 2002-02-21 | Microflow Engineering S.A., Neuenburg/Neuchatel | Sprühvorrichtung für einen Inhalator |
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| US6070575A (en) | 1998-11-16 | 2000-06-06 | Aradigm Corporation | Aerosol-forming porous membrane with certain pore structure |
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| DE60114393T2 (de) | 2000-04-11 | 2006-04-27 | Trudell Medical International, London | Aerosolspender mit einer möglichkeit für positiven ausatemdruck |
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| US9540336B2 (en) | 2011-12-22 | 2017-01-10 | The Trustees Of The University Of Pennsylvania | Therapeutic agents |
| AU2015244275B2 (en) | 2014-04-08 | 2019-08-29 | Aradigm Corporation | Liposomal ciprofloxacin formulations with activity against non-tuberculous mycobacteria |
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| Publication number | Publication date |
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| JP7377259B2 (ja) | 2023-11-09 |
| EP3840737A1 (en) | 2021-06-30 |
| KR20210090607A (ko) | 2021-07-20 |
| WO2020040818A1 (en) | 2020-02-27 |
| AU2019324330A1 (en) | 2021-03-04 |
| JP2024012393A (ja) | 2024-01-30 |
| CN112804993A (zh) | 2021-05-14 |
| JP2021535124A (ja) | 2021-12-16 |
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