CA3106271A1 - Methods, compositions, kits, and systems for selective enrichment of target cells - Google Patents

Methods, compositions, kits, and systems for selective enrichment of target cells Download PDF

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Publication number
CA3106271A1
CA3106271A1 CA3106271A CA3106271A CA3106271A1 CA 3106271 A1 CA3106271 A1 CA 3106271A1 CA 3106271 A CA3106271 A CA 3106271A CA 3106271 A CA3106271 A CA 3106271A CA 3106271 A1 CA3106271 A1 CA 3106271A1
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CA
Canada
Prior art keywords
cell
cells
target cell
subpopulation
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3106271A
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English (en)
French (fr)
Inventor
James Lim
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Xcell Biosciences Inc
Original Assignee
Xcell Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xcell Biosciences Inc filed Critical Xcell Biosciences Inc
Publication of CA3106271A1 publication Critical patent/CA3106271A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Sustainable Development (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3106271A 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells Abandoned CA3106271A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361756993P 2013-01-25 2013-01-25
US61/756,993 2013-01-25
US201361760626P 2013-02-04 2013-02-04
US61/760,626 2013-02-04
CA2895791A CA2895791A1 (en) 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2895791A Division CA2895791A1 (en) 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells

Publications (1)

Publication Number Publication Date
CA3106271A1 true CA3106271A1 (en) 2014-07-31

Family

ID=51223330

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3106271A Abandoned CA3106271A1 (en) 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells
CA2895791A Abandoned CA2895791A1 (en) 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2895791A Abandoned CA2895791A1 (en) 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells

Country Status (8)

Country Link
US (2) US9857360B2 (enExample)
EP (1) EP2948776B8 (enExample)
JP (1) JP6509745B2 (enExample)
CN (2) CN104956226B (enExample)
AU (1) AU2014209218B2 (enExample)
CA (2) CA3106271A1 (enExample)
GB (1) GB2516196B (enExample)
WO (1) WO2014117021A2 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012213838A1 (de) 2012-08-03 2014-02-06 Katharina Pachmann Verfahren zur Kultivierung einer Subpopulation zirkulierender epithelialer Tumorzellen aus einer Körperflüssigkeit
WO2016081554A1 (en) * 2014-11-18 2016-05-26 Neostem Oncology, Llc Immunogenic compositions prepared from tumor cells derived from peripheral blood and originating from a solid tumor and their use
US10696937B2 (en) 2015-03-31 2020-06-30 Thrive Bioscience, Inc. Cell culture incubators with integrated cell manipulation systems
WO2016161155A2 (en) 2015-03-31 2016-10-06 Thrive Bioscience, Inc. Automated cell culture incubator
US20180066223A1 (en) 2015-04-17 2018-03-08 Xcell Biosciences, Inc. Cancer cell enrichment system
US20180100134A1 (en) * 2015-04-17 2018-04-12 Xcell Biosciences, Inc. Cancer cell enrichment system
TWI737631B (zh) 2015-10-01 2021-09-01 美商柏克萊燈光有限公司 多槽盤培養器
WO2017070353A1 (en) * 2015-10-20 2017-04-27 Celcuity Llc Methods of preparing a primary cell sample
CN105866412A (zh) * 2015-11-22 2016-08-17 李静 一种子宫内膜癌特异性检测的试剂盒
US11753626B2 (en) 2016-03-09 2023-09-12 Beijing Percans Oncology Co., Ltd. Tumor cell suspension cultures and related methods
US10941374B2 (en) 2016-09-29 2021-03-09 Sumitomo Rubber Industries, Ltd. Medical analysis device and cell analysis method
JP6485783B2 (ja) * 2016-09-29 2019-03-20 住友ゴム工業株式会社 医療用検査装置及び細胞検査方法
JP6779483B2 (ja) 2016-09-29 2020-11-04 住友ゴム工業株式会社 医療用検査装置及び細胞検査方法
WO2018218485A1 (en) * 2017-05-31 2018-12-06 Beijing Percans Oncology Co. Ltd. Epithelial tumor cell cultures
WO2018090375A1 (en) * 2016-11-21 2018-05-24 Beijing Percans Oncology Co. Ltd. Epithelial tumor cell cultures
KR102546384B1 (ko) * 2016-12-01 2023-06-21 버클리 라잇츠, 인크. 웰 플레이트 인큐베이터
IT201700024609A1 (it) * 2017-03-06 2018-09-06 Mollace Vincenzo Metodo e kit per la diagnosi e/o prognosi di tumori non ematologici
TWI616526B (zh) * 2017-05-15 2018-03-01 Cell separation and purification device
WO2019040646A2 (en) * 2017-08-24 2019-02-28 Nano Global Corp. DETECTION OF BIOLOGICAL CELLS OR BIOLOGICAL SUBSTANCES
KR101996218B1 (ko) * 2017-09-05 2019-10-01 주식회사 싸이토젠 Axl 기반 암환자 스크리닝 방법
WO2019074886A1 (en) 2017-10-09 2019-04-18 Terumo Bct Biotechnologies, Llc LYOPHILIZATION CONTAINER AND METHOD OF USE
WO2019090355A1 (en) * 2017-11-06 2019-05-09 Children's National Medical Center Cells expressing antibodies and methods of treatment using the same
CN111630604A (zh) * 2017-11-20 2020-09-04 纳诺全球公司 基于生物细胞或生物物质的检测的数据收集和分析
CN107858433B (zh) * 2017-12-15 2019-01-25 武汉迈特维尔生物科技有限公司 一种用于检测精原细胞瘤的试剂盒
US11365390B2 (en) 2017-12-19 2022-06-21 Xcell Biosciences, Inc. Methods of modulating cell phenotype by way of regulating the gaseous environment
JP7109719B2 (ja) 2018-02-14 2022-08-01 住友ゴム工業株式会社 特定細胞捕捉方法
CN108641956A (zh) * 2018-06-19 2018-10-12 张起 一种贴壁型细胞培养系统
CN109593720A (zh) * 2018-11-20 2019-04-09 叶春玲 一种永生化人鳞状乳头型颅咽管瘤细胞株及其应用
US12220465B2 (en) * 2018-11-28 2025-02-11 Washington University Compositions and methods for targeted treatment and imaging of cancer or tumors
US12642786B2 (en) 2018-12-07 2026-06-02 The Johns Hopkins University Methods, compositions and kits for treating multiple sclerosis and other disorders
CN109652376B (zh) * 2019-01-08 2021-10-15 创芯国际生物科技(广州)有限公司 一种用于卵巢癌组织3d培养的培养基
US11614440B2 (en) 2019-01-24 2023-03-28 Sumitomo Rubber Industries, Ltd. Specific cell fractionating and capturing methods
WO2020159879A2 (en) * 2019-01-28 2020-08-06 Nano Global Corp. Amelioration based on detection of biological cells or biological substances
CN111487404B (zh) * 2019-01-28 2024-01-05 猎源(上海)生物医药科技有限公司 体液肿瘤细胞dna提取试剂盒
CN109738309B (zh) * 2019-01-31 2021-07-20 河北超威电源有限公司 基于数值分析的铅炭动力电池极板检测方法
US11609042B2 (en) 2019-03-14 2023-03-21 Terumo Bct Biotechnologies, Llc Multi-part lyophilization container and method of use
CN111751543A (zh) * 2019-03-27 2020-10-09 南方医科大学南方医院 一种稀有肿瘤细胞富集方法及试剂盒
EP3962604A4 (en) * 2019-04-30 2023-02-08 Xcell Biosciences Inc. SYSTEMS AND METHODS FOR MODULATION OF A CELL PHENOTYPE
TWI790399B (zh) * 2019-08-30 2023-01-21 長庚大學 循環腫瘤細胞資訊評估方法及其分析方法
WO2021183900A1 (en) * 2020-03-12 2021-09-16 eXo Cell, LLC Methods and systems for transportation and culture of buoyant tissue
KR102400263B1 (ko) * 2020-04-08 2022-05-20 이엔셀 주식회사 줄기세포 초기 수율 촉진을 위한 줄기세포 배양 방법
CN111754457B (zh) * 2020-05-15 2023-08-18 中山大学 一种基于角膜共聚焦图像的菌丝筛查系统
CN113025712A (zh) * 2021-02-09 2021-06-25 中国人民解放军海军军医大学 一种检测肿瘤干细胞中遗传和表观遗传变化的方法
CN113981148A (zh) * 2021-11-18 2022-01-28 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) 一种鉴别rv感染以及鉴定病毒基因型的方法及其应用
CN115170848B (zh) * 2022-06-08 2025-12-19 皖南医学院第一附属医院(皖南医学院弋矶山医院) 一种基于骨髓活检图像的造血组织比例确定方法
CN117448270B (zh) * 2023-12-22 2024-07-26 上海元戊医学技术有限公司 一种高效诱导多能干细胞分化为中脑多巴胺能神经前体细胞的方法

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034062A (en) 1975-03-20 1977-07-05 Borden, Inc. Removal of oxygen from gas stream with copper catalyst
US5330915A (en) 1991-10-18 1994-07-19 Endotronics, Inc. Pressure control system for a bioreactor
US6322989B1 (en) 1991-11-25 2001-11-27 Yoreh Biotechnologies, Ltd. Whole blood/mitogen assay for the early detection of a subject with ovarian or breast cancer and kit
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US5922687A (en) 1995-05-04 1999-07-13 Board Of Trustees Of The Leland Stanford Junior University Intracellular delivery of nucleic acids using pressure
US5882914A (en) * 1995-06-06 1999-03-16 The Johns Hopkins University School Of Medicine Nucleic acids encoding the hypoxia inducible factor-1
US20040072722A1 (en) 2002-10-10 2004-04-15 Kornblith Paul L. Methods for assessing efficacy of chemotherapeutic agents
CA2306090A1 (en) 1997-10-24 1999-05-06 Christopher W. Mcdaniel Delivery vehicles for bioactive agents and uses thereof
US7282350B2 (en) 1998-02-12 2007-10-16 Immunivest Corporation Labeled cell sets for use as functional controls in rare cell detection assays
WO1999041613A1 (en) 1998-02-12 1999-08-19 Immunivest Methods and reagents for the rapid and efficient isolation of circulating cancer cells
EP1064353B1 (en) 1998-03-18 2002-11-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US6610540B1 (en) * 1998-11-18 2003-08-26 California Institute Of Technology Low oxygen culturing of central nervous system progenitor cells
US6184035B1 (en) 1998-11-18 2001-02-06 California Institute Of Technology Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells
US8131053B2 (en) 1999-01-25 2012-03-06 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US6656683B1 (en) 2000-07-05 2003-12-02 Board Of Regents, The University Of Texas System Laser scanning cytology with digital image capture
US7785810B2 (en) 2000-09-09 2010-08-31 The Research Foundation Of State University Of New York Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof
US20040151705A1 (en) 2002-03-22 2004-08-05 Shuichi Mizuno Neo-cartilage constructs and a method for preparation thereof
US7863012B2 (en) 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
US20030092178A1 (en) 2001-11-15 2003-05-15 Biospherix, Ltd. Cell culture incubator with dynamic oxygen control
US20050244843A1 (en) 2001-11-16 2005-11-03 Wen-Tien Chen Blood test prototypes and methods for the detection of circulating tumor and endothelial cells
US7435587B2 (en) 2002-03-01 2008-10-14 Memorial Sloan-Kettering Cancer Center Apparatus for growing cells under variable hydrostatic pressures
ATE331958T1 (de) 2002-03-13 2006-07-15 Biomerieux Sa Verfahren zum nachweis und zur quantifizierung von -aus soliden tumoren abstammenden- zirkulierenden tumorzellen
JP2004180675A (ja) 2002-11-19 2004-07-02 Sanyo Electric Co Ltd インキュベータ
US7367550B2 (en) 2003-11-18 2008-05-06 Massachusetts Institute Of Technology Peristaltic mixing and oxygenation system
ATE527369T1 (de) 2003-12-23 2011-10-15 Monsanto Technology Llc Verwendung einer sauerstoffarmen umgebung bei der transformation von pflanzen
GB0403611D0 (en) 2004-02-18 2004-03-24 Univ Glasgow Analysis of cell morphology and motility
PT1773978E (pt) 2004-05-19 2014-05-29 Massachusetts Inst Technology Modelo de doença com células/tecidos tri-dimensionais perfundidos
US7629128B2 (en) * 2004-08-30 2009-12-08 Prolx Pharmaceuticals Corp. Methods of identifying respondents to hypoxia inducible factor 1-α inhibitors
US20060094109A1 (en) 2004-11-02 2006-05-04 Immunivest Corporation Device and method for analytical cell imaging
WO2006100987A1 (ja) 2005-03-18 2006-09-28 Nippon Shokubai Co., Ltd. 酸素除去触媒および当該触媒を用いた酸素除去方法
US7476541B1 (en) 2005-03-29 2009-01-13 Timothy F. Dutra Bioreactor system and method for the production and collection of blood cells from engineered bone marrow tissue
US20070026417A1 (en) 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US8367405B2 (en) * 2005-04-12 2013-02-05 Mesoblast, Inc. Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase
JP4744187B2 (ja) * 2005-05-10 2011-08-10 オリンパス株式会社 細胞観察装置
WO2007012071A1 (en) 2005-07-20 2007-01-25 Government Of The United States Of America, As Represented By The Secretary, Department Of Health Bioreactor device, and method and system for fabricating tissues in the bioreactor device
WO2007089911A2 (en) 2006-01-30 2007-08-09 The Scripps Research Institute Methods for detection of circulating tumor cells and methods of diagnosis of cancer in a mammalian subject
CN101500512B (zh) 2006-02-07 2011-08-24 脊柱赛特有限公司 使用生物反应器的修复软骨的方法和组合物
CA2647280A1 (en) 2006-03-13 2007-09-20 Veridex, Llc Propagation of primary cells
US20090304644A1 (en) 2006-05-30 2009-12-10 Cytori Therapeutics, Inc. Systems and methods for manipulation of regenerative cells separated and concentrated from adipose tissue
AU2007255110B8 (en) 2006-06-02 2014-04-10 Pfizer Products Inc. Circulating tumor cell assay
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2049646A2 (en) 2006-07-14 2009-04-22 Xcellerex, Inc. Environmental containment systems
US7735670B2 (en) 2006-10-17 2010-06-15 Honeywell International Inc. Oxygen removal system
EP2136630A4 (en) * 2007-03-23 2010-06-02 Precision Therapeutics Inc METHOD FOR EVALUATING THE ANGIOGENIC POTENTIAL IN CULTURE
MX348010B (es) 2007-04-07 2017-05-23 Whitehead Inst Biomedical Res Reprogramacion de celulas somaticas.
WO2008131048A2 (en) 2007-04-16 2008-10-30 Cellpoint Diagnotics, Inc. Devices and methods for diagnosing, prognosing, or theranosing a condition by enriching rare cells
WO2008156708A2 (en) 2007-06-15 2008-12-24 Massachusetts Institute Of Technology Methods and compositions for enhanced differentiation from embryonic stem cells
GB0713121D0 (en) * 2007-07-06 2007-08-15 Univ Keele Refrigerated gas equilibration device
US8303522B2 (en) 2007-10-18 2012-11-06 The Curators Of The University Of Missouri Device for transfecting cells using shock waves generated by the ignition of nanoenergetic materials
US8071395B2 (en) 2007-12-12 2011-12-06 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for magnetic separation of cells
US20090186006A1 (en) * 2008-01-16 2009-07-23 Murphy Michael P Placental vascular lobule stem cells
KR101685209B1 (ko) 2008-07-30 2016-12-09 고쿠리츠 다이가쿠 호진 교토 다이가쿠 유도된 다능성 줄기 세포의 효율적인 확립 방법
EP2335075A4 (en) 2008-09-05 2011-12-14 Scripps Research Inst METHOD FOR DETECTING CIRCULATING TUMOR CELLS
KR102428795B1 (ko) * 2008-11-12 2022-08-04 인리젠 분리된 신장 세포 및 이의 용도
WO2010057013A1 (en) 2008-11-14 2010-05-20 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
GB201111244D0 (en) * 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
US20120100538A1 (en) 2009-03-24 2012-04-26 Biocept, Inc. Devices and methods of cell capture and analysis
KR101109125B1 (ko) 2009-03-24 2012-02-15 한국과학기술연구원 줄기세포를 혈관세포로 분화시키는 방법 및 이를 이용한 생체 내 혈관신생 유도
WO2010115187A1 (en) 2009-04-03 2010-10-07 Duke University Methods of making cell sheets, tissue sheets and tissue engineered blood vessels
US8551425B2 (en) 2009-05-20 2013-10-08 California Institute Of Technology Method for cancer detection, diagnosis and prognosis
AU2010271212B2 (en) 2009-07-10 2015-07-16 Histogen, Inc. Conditioned medium and extracellular matrix compositions from cells cultured under hypoxic conditions
US8501397B2 (en) * 2009-07-24 2013-08-06 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Enrichment of stem cells from adult tissues
US8900860B2 (en) 2009-11-30 2014-12-02 National Yang-Ming University Method for expanding mesenchymal stem cells in low-density and hypoxic culture
WO2011113036A2 (en) * 2010-03-12 2011-09-15 Whitehead Institute For Biomedical Research Compositions and methods for expanding bfu-e cells
JP5703302B2 (ja) 2010-09-08 2015-04-15 株式会社島津製作所 細胞培養容器及びその容器を用いた細胞培養方法
EP2638149B1 (en) 2010-11-12 2019-05-15 Georgetown University Immortalization of epithelial cells and methods of use
US9404986B2 (en) * 2011-05-06 2016-08-02 The Regents Of The University Of California Measuring biological tissue parameters using diffusion magnetic resonance imaging
AU2013214187B2 (en) 2012-02-03 2017-02-09 Technische Universitat Munchen - Klinikum Rechts Der Isar Device-based methods for localised delivery of cell-free carriers with stress-induced cellular factors
AU2013251649B2 (en) 2012-04-24 2019-04-04 Vcell Therapeutics, Inc. Generating pluripotent cells de novo
US9447378B2 (en) 2012-04-27 2016-09-20 Massachusetts Institute Of Technology Method for differentiating human embryonic stem cells into β-cells for the treatment of type I diabetes
CN103014118B (zh) * 2013-01-10 2014-05-14 贵州大学 一种用于抗癌药物筛选的细胞共培养方法
CN103387963B (zh) * 2013-08-12 2015-05-20 厦门大学附属中山医院 一株Ming氏人膨胀型胃癌细胞系及其应用
EP3059299B1 (en) 2013-10-15 2020-05-13 Hitachi, Ltd. Cell culturing device
US20150247112A1 (en) 2014-03-03 2015-09-03 Kiyatec Inc. 3D Tissue Culture Devices and Systems

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