CA3105099A1 - Inhibiting creb binding protein (cbp) - Google Patents

Inhibiting creb binding protein (cbp) Download PDF

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Publication number
CA3105099A1
CA3105099A1 CA3105099A CA3105099A CA3105099A1 CA 3105099 A1 CA3105099 A1 CA 3105099A1 CA 3105099 A CA3105099 A CA 3105099A CA 3105099 A CA3105099 A CA 3105099A CA 3105099 A1 CA3105099 A1 CA 3105099A1
Authority
CA
Canada
Prior art keywords
c6alkyl
methyl
compound
aryl
heterocyclyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3105099A
Other languages
English (en)
French (fr)
Inventor
Shawn E.R. Schiller
Torsten Herbertz
Hongbin Li
Bradford Graves
Steven Mischke
Angela V. West
Anna Ericsson
Jennifer R. DOWNING
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forma Therapeutics Inc
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2018/051214 external-priority patent/WO2019055869A1/en
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of CA3105099A1 publication Critical patent/CA3105099A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3105099A 2018-06-29 2019-06-28 Inhibiting creb binding protein (cbp) Pending CA3105099A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862692593P 2018-06-29 2018-06-29
US62/692,593 2018-06-29
USPCT/US2018/051214 2018-09-14
PCT/US2018/051214 WO2019055869A1 (en) 2017-09-15 2018-09-14 TETRAHYDROIMIDAZO QUINOLINE COMPOSITIONS AS INHIBITORS OF CBP / P300
PCT/US2018/051235 WO2019055877A1 (en) 2017-09-15 2018-09-14 TETRAHYDROIMIDAZO QUINOLINE COMPOSITIONS AS INHIBITORS OF CBP / P300
USPCT/US2018/051235 2018-09-14
US201962819490P 2019-03-15 2019-03-15
US62/819,490 2019-03-15
PCT/US2019/039936 WO2020006483A1 (en) 2018-06-29 2019-06-28 Inhibiting creb binding protein (cbp)

Publications (1)

Publication Number Publication Date
CA3105099A1 true CA3105099A1 (en) 2020-01-02

Family

ID=68987627

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3105099A Pending CA3105099A1 (en) 2018-06-29 2019-06-28 Inhibiting creb binding protein (cbp)

Country Status (26)

Country Link
US (3) US10870648B2 (https=)
EP (1) EP3998266A1 (https=)
JP (4) JP6781806B2 (https=)
KR (2) KR20250067962A (https=)
CN (2) CN112513038B (https=)
AU (3) AU2019295790B2 (https=)
BR (1) BR112020026783A2 (https=)
CA (1) CA3105099A1 (https=)
CY (1) CY1124762T1 (https=)
DK (1) DK3587418T3 (https=)
ES (1) ES2900105T3 (https=)
HR (1) HRP20211698T1 (https=)
HU (1) HUE056885T2 (https=)
IL (3) IL279734B2 (https=)
LT (1) LT3587418T (https=)
MA (1) MA50675B1 (https=)
MX (2) MX2023013508A (https=)
PL (1) PL3587418T3 (https=)
PT (1) PT3587418T (https=)
RS (1) RS62732B1 (https=)
SA (1) SA520420909B1 (https=)
SG (1) SG11202012767UA (https=)
SI (1) SI3587418T1 (https=)
SM (1) SMT202100636T1 (https=)
WO (1) WO2020006483A1 (https=)
ZA (2) ZA202100509B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL279734B2 (en) * 2018-06-29 2024-11-01 Forma Therapeutics Inc Inhibiting creb binding protein (cbp)
US12351577B2 (en) 2019-03-15 2025-07-08 Forma Therapeutics, Inc. Inhibiting cyclic AMP-responsive element-binding protein (CREB)
AU2020241709B2 (en) * 2019-03-15 2025-12-04 Forma Therapeutics, Inc. Compositions and methods for treating androgen receptor positive forms of cancer
IL299344A (en) 2020-06-25 2023-02-01 Tolremo Therapeutics Ag Combination of a cbp/p300 bromodomain inhibitor and a kras inhibitor for the treatment of cancer
AU2021298153A1 (en) 2020-06-25 2023-02-23 Tolremo Therapeutics Ag A combination of a CBP/p300 bromodomain inhibitor and an EGFR inhibitor for use in treating EGFR-mutant NSCLC
US11795168B2 (en) 2020-09-23 2023-10-24 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)
US11801243B2 (en) 2020-09-23 2023-10-31 Forma Therapeutics, Inc. Bromodomain inhibitors for androgen receptor-driven cancers

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Also Published As

Publication number Publication date
AU2023226653B2 (en) 2025-09-04
US12378242B2 (en) 2025-08-05
SG11202012767UA (en) 2021-01-28
CN112513038B (zh) 2023-01-10
SMT202100636T1 (it) 2022-01-10
BR112020026783A2 (pt) 2021-03-30
US10870648B2 (en) 2020-12-22
ZA202210560B (en) 2025-12-17
JP2020002135A (ja) 2020-01-09
MA50675B1 (fr) 2021-09-30
JP2021042255A (ja) 2021-03-18
LT3587418T (lt) 2021-11-25
MA50675A (fr) 2021-04-07
IL279734B1 (en) 2024-07-01
PL3587418T3 (pl) 2022-02-21
HUE056885T2 (hu) 2022-03-28
MX2020014303A (es) 2021-03-25
JP2025094157A (ja) 2025-06-24
IL313466B1 (en) 2025-07-01
JP6781806B2 (ja) 2020-11-04
HRP20211698T1 (hr) 2022-02-18
DK3587418T3 (da) 2021-10-11
CY1124762T1 (el) 2022-07-22
JP2020128426A (ja) 2020-08-27
EP3998266A1 (en) 2022-05-18
US20220162207A1 (en) 2022-05-26
ES2900105T3 (es) 2022-03-15
KR102805503B1 (ko) 2025-05-09
ZA202100509B (en) 2022-12-21
IL279734A (en) 2021-03-01
SI3587418T1 (sl) 2022-03-31
IL313466A (en) 2024-08-01
US20200299295A1 (en) 2020-09-24
AU2025210762A1 (en) 2025-08-21
RS62732B1 (sr) 2022-01-31
PT3587418T (pt) 2021-12-02
AU2019295790B2 (en) 2023-07-13
IL321337A (en) 2025-08-01
AU2019295790A1 (en) 2021-01-28
US11254674B2 (en) 2022-02-22
JP7017801B2 (ja) 2022-02-09
KR20250067962A (ko) 2025-05-15
MX2023013508A (es) 2023-12-13
WO2020006483A1 (en) 2020-01-02
IL279734B2 (en) 2024-11-01
SA520420909B1 (ar) 2024-11-12
CN112513038A (zh) 2021-03-16
IL313466B2 (en) 2025-11-01
AU2023226653A1 (en) 2023-09-21
KR20210025631A (ko) 2021-03-09
CN116178369A (zh) 2023-05-30
US20200002332A1 (en) 2020-01-02

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