CA3095582A1 - Heterotandem bicyclic peptide complexes - Google Patents

Info

Publication number

CA3095582A1

CA3095582A1 CA3095582A CA3095582A CA3095582A1 CA 3095582 A1 CA3095582 A1 CA 3095582A1 CA 3095582 A CA3095582 A CA 3095582A CA 3095582 A CA3095582 A CA 3095582A CA 3095582 A1 CA3095582 A1 CA 3095582A1

Authority

CA

Canada

Prior art keywords

pmol

compound

seq

bicyclic peptide

hereinafter referred

Prior art date

2018-04-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• CIPO
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• 108010074708 B7-H1 Antigen Proteins 0.000 claims description 34
• 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 34
• 150000003839 salts Chemical class 0.000 claims description 34
• ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 30
• 210000004881 tumor cell Anatomy 0.000 claims description 30
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 29
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• 239000002062 molecular scaffold Substances 0.000 claims description 24
• LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims description 23
• 150000001413 amino acids Chemical group 0.000 claims description 21
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• UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical group NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims description 16
• MLBYLEUJXUBIJJ-UHFFFAOYSA-N pent-4-ynoic acid Chemical group OC(=O)CCC#C MLBYLEUJXUBIJJ-UHFFFAOYSA-N 0.000 claims description 12
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 11
• PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 10
• QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 claims description 10
• QUOGESRFPZDMMT-YFKPBYRVSA-N L-homoarginine Chemical compound OC(=O)[C@@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-YFKPBYRVSA-N 0.000 claims description 10
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