CA3093078A1 - Prostate-specific membrane antigen cars and methods of use thereof - Google Patents

Prostate-specific membrane antigen cars and methods of use thereof Download PDF

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Publication number
CA3093078A1
CA3093078A1 CA3093078A CA3093078A CA3093078A1 CA 3093078 A1 CA3093078 A1 CA 3093078A1 CA 3093078 A CA3093078 A CA 3093078A CA 3093078 A CA3093078 A CA 3093078A CA 3093078 A1 CA3093078 A1 CA 3093078A1
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Prior art keywords
acid sequence
domain
seq
set forth
cell
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CA3093078A
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English (en)
French (fr)
Inventor
Yangbing Zhao
Szu Hua Sharon LIN
Xiaojun Liu
Anne Chew
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University of Pennsylvania Penn
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University of Pennsylvania Penn
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Publication of CA3093078A1 publication Critical patent/CA3093078A1/en
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K40/4276—Prostate specific membrane antigen [PSMA]
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CA3093078A 2018-03-06 2019-03-05 Prostate-specific membrane antigen cars and methods of use thereof Pending CA3093078A1 (en)

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US201862639321P 2018-03-06 2018-03-06
US62/639,321 2018-03-06
PCT/US2019/020729 WO2019173324A1 (en) 2018-03-06 2019-03-05 Prostate-specific membrane antigen cars and methods of use thereof

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EP (2) EP3762410A4 (enExample)
JP (4) JP7526097B2 (enExample)
KR (1) KR20200130709A (enExample)
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AU (2) AU2019231205A1 (enExample)
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MX (1) MX2020009272A (enExample)
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Families Citing this family (35)

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WO2010099205A1 (en) * 2009-02-24 2010-09-02 The Trustees Of The University Of Pennsylvania Methods for treating progressive multifocal leukoencephalopathy (pml)
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
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