CA3086665A1 - Heavy chain antibodies binding to cd22 - Google Patents

Heavy chain antibodies binding to cd22 Download PDF

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Publication number
CA3086665A1
CA3086665A1 CA3086665A CA3086665A CA3086665A1 CA 3086665 A1 CA3086665 A1 CA 3086665A1 CA 3086665 A CA3086665 A CA 3086665A CA 3086665 A CA3086665 A CA 3086665A CA 3086665 A1 CA3086665 A1 CA 3086665A1
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CA
Canada
Prior art keywords
heavy chain
antibody
seq
sequence
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3086665A
Other languages
English (en)
French (fr)
Inventor
Shelley Force Aldred
Wim Van Schooten
Heather Anne N. OGANA
Laura Marie DAVISON
Katherine HARRIS
Udaya RANGASWAMY
Nathan D. Trinklein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TeneoBio Inc
Original Assignee
TeneoBio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TeneoBio Inc filed Critical TeneoBio Inc
Publication of CA3086665A1 publication Critical patent/CA3086665A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3086665A 2017-12-22 2018-12-21 Heavy chain antibodies binding to cd22 Pending CA3086665A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762609759P 2017-12-22 2017-12-22
US62/609,759 2017-12-22
PCT/US2018/067299 WO2019126756A1 (en) 2017-12-22 2018-12-21 Heavy chain antibodies binding to cd22

Publications (1)

Publication Number Publication Date
CA3086665A1 true CA3086665A1 (en) 2019-06-27

Family

ID=65041936

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3086665A Pending CA3086665A1 (en) 2017-12-22 2018-12-21 Heavy chain antibodies binding to cd22

Country Status (24)

Country Link
US (2) US11873336B2 (https=)
EP (1) EP3728319A1 (https=)
JP (2) JP7486421B2 (https=)
KR (2) KR102823263B1 (https=)
CN (1) CN111683966B (https=)
AU (1) AU2018392088A1 (https=)
BR (1) BR112020012554A2 (https=)
CA (1) CA3086665A1 (https=)
CL (3) CL2020001703A1 (https=)
CO (1) CO2020008925A2 (https=)
CR (1) CR20200322A (https=)
EA (1) EA202091557A1 (https=)
EC (1) ECSP20042489A (https=)
IL (1) IL275498B1 (https=)
JO (1) JOP20200157B1 (https=)
MX (1) MX2020006494A (https=)
MY (1) MY204744A (https=)
NI (1) NI202000050A (https=)
PE (1) PE20201171A1 (https=)
PH (1) PH12020550964A1 (https=)
SA (1) SA520412283B1 (https=)
SG (1) SG11202005880XA (https=)
UA (1) UA128757C2 (https=)
WO (1) WO2019126756A1 (https=)

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CO2020008925A2 (es) 2020-10-30
JP7486421B2 (ja) 2024-05-17
CL2022002247A1 (es) 2023-02-24
SG11202005880XA (en) 2020-07-29
EA202091557A1 (ru) 2020-11-18
WO2019126756A1 (en) 2019-06-27
IL275498B1 (en) 2026-01-01
US11873336B2 (en) 2024-01-16
BR112020012554A2 (pt) 2020-11-24
NI202000050A (es) 2020-12-04
MX2020006494A (es) 2020-11-24
RU2020124188A (ru) 2022-01-24
CN111683966B (zh) 2023-07-11
EP3728319A1 (en) 2020-10-28
CL2024002319A1 (es) 2024-12-06
KR20250093583A (ko) 2025-06-24
PE20201171A1 (es) 2020-10-28
US20210095022A1 (en) 2021-04-01
IL275498A (en) 2020-08-31
KR102823263B1 (ko) 2025-06-24
SA520412283B1 (ar) 2024-08-05
US20240117046A1 (en) 2024-04-11
JOP20200157B1 (ar) 2024-12-22
CL2020001703A1 (es) 2020-11-06
CN111683966A (zh) 2020-09-18
UA128757C2 (uk) 2024-10-16
WO2019126756A9 (en) 2019-10-17
PH12020550964A1 (en) 2021-03-22
KR20200104342A (ko) 2020-09-03
JP2024062992A (ja) 2024-05-10
JP2021506325A (ja) 2021-02-22
JOP20200157A1 (ar) 2022-10-30
AU2018392088A2 (en) 2020-08-27
ECSP20042489A (es) 2020-11-30
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MY204744A (en) 2024-09-11
CR20200322A (es) 2021-01-12

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