CA3078253A1 - Anti-cd47 agent-based ovarian cancer therapy - Google Patents
Anti-cd47 agent-based ovarian cancer therapy Download PDFInfo
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- CA3078253A1 CA3078253A1 CA3078253A CA3078253A CA3078253A1 CA 3078253 A1 CA3078253 A1 CA 3078253A1 CA 3078253 A CA3078253 A CA 3078253A CA 3078253 A CA3078253 A CA 3078253A CA 3078253 A1 CA3078253 A1 CA 3078253A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Molecular Biology (AREA)
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- Biophysics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762573835P | 2017-10-18 | 2017-10-18 | |
| US62/573,835 | 2017-10-18 | ||
| PCT/US2018/056441 WO2019079548A1 (en) | 2017-10-18 | 2018-10-18 | OVARIAN CANCER THERAPY BASED ON ANTI-CD47 AGENT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3078253A1 true CA3078253A1 (en) | 2019-04-25 |
Family
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Family Applications (1)
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|---|---|---|---|
| CA3078253A Pending CA3078253A1 (en) | 2017-10-18 | 2018-10-18 | Anti-cd47 agent-based ovarian cancer therapy |
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|---|---|
| US (2) | US11802153B2 (enExample) |
| EP (2) | EP3697817B1 (enExample) |
| JP (2) | JP7308191B2 (enExample) |
| KR (1) | KR102776457B1 (enExample) |
| CN (2) | CN117771364A (enExample) |
| AU (1) | AU2018351006B2 (enExample) |
| CA (1) | CA3078253A1 (enExample) |
| ES (2) | ES2932286T3 (enExample) |
| PL (2) | PL4177270T3 (enExample) |
| PT (2) | PT3697817T (enExample) |
| SI (2) | SI4177270T1 (enExample) |
| WO (1) | WO2019079548A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3402820T1 (sl) | 2016-01-11 | 2021-04-30 | Forty Seven, Inc. | Humanizirana, mišja ali himerna monoklonska protitelesa proti-CD47 |
| AU2018351006B2 (en) | 2017-10-18 | 2024-08-29 | Forty Seven, LLC | Anti-CD47 agent-based ovarian cancer therapy |
| PT3752190T (pt) | 2018-02-12 | 2022-11-18 | Forty Seven Inc | Regime anticancerígeno usando anticorpos anti-cd47 e anti-cd20 |
| CN112739384A (zh) * | 2018-09-04 | 2021-04-30 | 延龄草治疗公司 | 用于疾病治疗的cd47阻断和parp抑制 |
| IL293926A (en) | 2019-12-17 | 2022-08-01 | Pfizer | Antibodies specific for cd47, pd-l1, and uses thereof |
| CN115361971A (zh) * | 2020-04-06 | 2022-11-18 | 里兰斯坦福初级大学理事会 | 抗体制剂 |
| CN115956088A (zh) * | 2020-06-22 | 2023-04-11 | 莫佛塞斯公司 | 包括抗-CD19抗体和阻断SIRPα-CD47先天免疫检查点的多肽的抗肿瘤组合疗法 |
| US20240139198A1 (en) * | 2021-02-10 | 2024-05-02 | Curon Biopharmaceutical (Shanghai) Co., Limited | Method and combination for treating tumors |
| AU2022258273A1 (en) * | 2021-04-14 | 2023-09-14 | Akeso Biopharma, Inc | Anti-cd47 monoclonal antibody and use thereof |
| AU2022289317A1 (en) * | 2021-06-10 | 2023-12-14 | Ono Pharmaceutical Co., Ltd. | Method for treating cancer through combination of cd47 inhibitor, immune checkpoint inhibitor, and standard therapy |
| CN115245516A (zh) * | 2021-12-31 | 2022-10-28 | 郑州大学第一附属医院 | 一种抗卵巢癌肿瘤药物联用方法、体外和体内验证方法 |
| WO2023172643A1 (en) * | 2022-03-08 | 2023-09-14 | Whitehead Institute For Biomedical Research | The combination of macrophage-directed immunotherapy and targeted agents for treatment of cancer |
| TWI876305B (zh) * | 2022-04-05 | 2025-03-11 | 美商基利科學股份有限公司 | 用於治療結腸直腸癌之組合療法 |
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| PT3056515T (pt) | 2008-01-15 | 2019-07-19 | Univ Leland Stanford Junior | Métodos para manipulação da fagocitose mediada por cd47 |
| EP4134095A1 (en) | 2009-09-15 | 2023-02-15 | The Board of Trustees of the Leland Stanford Junior University | Synergistic anti-cd47 therapy for hematologic cancers |
| US9151760B2 (en) | 2009-09-29 | 2015-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Isolation and use of melanoma cancer stem cells |
| HUE060541T2 (hu) | 2010-05-14 | 2023-03-28 | Univ Leland Stanford Junior | Humanizált és kiméra monoklonális CD47 elleni ellenanyagok |
| US20140271683A1 (en) | 2010-12-21 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Therapeutic and Diagnostic Methods for Manipulating Phagocytosis Through Calreticulin and Low Density Lipoprotein-Related Receptor |
| PT2804617T (pt) | 2012-01-17 | 2020-09-10 | Univ Leland Stanford Junior | Reagentes sirp-alfa de alta afinidade |
| JP6572131B2 (ja) | 2012-12-12 | 2019-09-04 | バスキュロックス インコーポレイテッド | 治療用ｃｄ４７抗体 |
| CN112245586A (zh) | 2013-03-15 | 2021-01-22 | 小利兰·斯坦福大学托管委员会 | 用于实现治疗有效剂量的抗cd47剂的方法 |
| US10064925B2 (en) | 2013-04-29 | 2018-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Use of anti-CD47 agents to enhance immunization |
| WO2014186761A2 (en) | 2013-05-17 | 2014-11-20 | The Board Of Trustes Of The Leland Stanford Junior University | Methods for determining responsiveness to an anti-cd47 agent |
| CA2939293C (en) | 2014-03-11 | 2023-10-03 | The Board Of Trustees Of The Leland Standford Junior University | Anti sirp-alpha antibodies and bi-specific macrophage enhancing antibodies |
| PL3177640T3 (pl) | 2014-08-08 | 2020-11-02 | The Board Of Trustees Of The Leland Stanford Junior University | Charakteryzujące się wysokim powinowactwem środki terapeutyczne naśladujące PD-11 i sposoby ich wykorzystania |
| WO2016023001A1 (en) | 2014-08-08 | 2016-02-11 | The Board Of Trustees Of The Leland Stanford Junior University | Multispecific high affinity pd-1 agents and methods of use |
| PL3204018T3 (pl) | 2014-10-07 | 2022-01-03 | Immunomedics, Inc. | Neoadiuwantowe zastosowanie koniugatów przeciwciało-lek |
| US10316094B2 (en) | 2014-10-24 | 2019-06-11 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for inducing phagocytosis of MHC class I positive cells and countering anti-CD47/SIRPA resistance |
| TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗ｐｄ－１抗體類和使用彼等之方法 |
| ES2761861T3 (es) | 2015-01-21 | 2020-05-21 | Univ Leland Stanford Junior | Uso de agonistas de TLR y agente anti-CD47 para mejorar la fagocitosis de las células cancerosas |
| US10358472B2 (en) | 2015-05-06 | 2019-07-23 | The Board Of Trustees Of The Leland Stanford Junior University | High affinity CD47 analogs |
| US20180147257A1 (en) | 2015-05-22 | 2018-05-31 | The Board Of Trustees Of The Leland Stanford Junior University | Btn3a ectodomain proteins and methods of use |
| WO2017019767A1 (en) | 2015-07-27 | 2017-02-02 | Myosotis, Llc | Inhibition of CXCL12 in Cancer Immunotherapy |
| JP7198083B2 (ja) | 2015-08-26 | 2022-12-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Ｃｄ４７遮断及び免疫同時刺激アゴニストを用いた標的細胞の枯渇亢進 |
| JP6885606B2 (ja) * | 2015-09-18 | 2021-06-16 | アーチ オンコロジー, インコーポレイテッドArch Oncology, Inc. | 治療用ｃｄ４７抗体 |
| WO2017100462A2 (en) * | 2015-12-11 | 2017-06-15 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of cancer with dual targeting of cd47 and egfr |
| CA3004369A1 (en) | 2015-12-28 | 2017-07-06 | Syndax Pharmaceuticals, Inc. | Combination of hdac inhibitor and anti-pd-l1 antibody for treatment of ovarian cancer |
| SI3402820T1 (sl) * | 2016-01-11 | 2021-04-30 | Forty Seven, Inc. | Humanizirana, mišja ali himerna monoklonska protitelesa proti-CD47 |
| CA3011429A1 (en) * | 2016-01-21 | 2017-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of cancer with combinations of immunoregulatory agents |
| ES2909835T3 (es) | 2016-04-15 | 2022-05-10 | Univ Leland Stanford Junior | Métodos para determinar y alcanzar dosis terapéuticamente efectivas de agentes anti-CD47 en el tratamiento del cáncer |
| EP3493845A4 (en) | 2016-08-03 | 2020-04-15 | The Board of Trustees of the Leland Stanford Junior University | INTERRUPTION OF FC RECEPTOR USE ON MACROPHAGES TO IMPROVE THE EFFECTIVENESS OF ANTI-SIRPALPHA ANTIBODY THERAPY |
| WO2018031419A1 (en) | 2016-08-12 | 2018-02-15 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for enhancing immunogenic cross-presentation of tumor antigens |
| US10995152B2 (en) | 2016-10-26 | 2021-05-04 | The Board Of Trustees Of The Leland Stanford Junior University | Modified immunoglobulin hinge regions to reduce hemagglutination |
| WO2018165015A1 (en) | 2017-03-09 | 2018-09-13 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of pediatric brain tumors with targeting of cd47 pathway |
| AU2018351006B2 (en) | 2017-10-18 | 2024-08-29 | Forty Seven, LLC | Anti-CD47 agent-based ovarian cancer therapy |
| WO2019079549A1 (en) | 2017-10-18 | 2019-04-25 | Forty Seven, Inc. | TREATMENT OF OVARY CANCER BY ANTI-CD47 AND ANTI-PD-L1 |
| EP3807319A4 (en) | 2018-06-13 | 2022-05-25 | The Board of Trustees of the Leland Stanford Junior University | Compositions and methods for inducing phagocytosis |
| US20220091104A1 (en) | 2018-09-28 | 2022-03-24 | The Board Of Trustees Of The Leland Stanford Junior University | Analysis of polymorphisms in sirp-alpha for evaluating response to immunotherapy |
| WO2020160285A1 (en) | 2019-02-01 | 2020-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | SIRPα EXPRESSION ON T CELLS IS A BIOMARKER FOR FUNCTIONAL T CELLS DURING EXHAUSTION |
| US20220119523A1 (en) | 2019-02-08 | 2022-04-21 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of cutaneous t cell lymphoma with targeting of cd47 pathway |
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2018
- 2018-10-18 AU AU2018351006A patent/AU2018351006B2/en active Active
- 2018-10-18 CA CA3078253A patent/CA3078253A1/en active Pending
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- 2018-10-18 PL PL22199536.8T patent/PL4177270T3/pl unknown
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2022
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2023
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| AU2018351006B2 (en) | 2024-08-29 |
| US20200283520A1 (en) | 2020-09-10 |
| CN111247172A (zh) | 2020-06-05 |
| JP2021500349A (ja) | 2021-01-07 |
| JP2023018062A (ja) | 2023-02-07 |
| WO2019079548A1 (en) | 2019-04-25 |
| PT3697817T (pt) | 2023-01-02 |
| PL4177270T3 (pl) | 2024-11-18 |
| ES2932286T3 (es) | 2023-01-17 |
| AU2018351006A1 (en) | 2020-05-07 |
| KR20200068730A (ko) | 2020-06-15 |
| JP7308191B2 (ja) | 2023-07-13 |
| US20240150461A1 (en) | 2024-05-09 |
| KR102776457B1 (ko) | 2025-03-06 |
| EP4177270A1 (en) | 2023-05-10 |
| PL3697817T3 (pl) | 2023-01-23 |
| CN117771364A (zh) | 2024-03-29 |
| SI4177270T1 (sl) | 2024-10-30 |
| EP3697817A1 (en) | 2020-08-26 |
| EP3697817B1 (en) | 2022-10-05 |
| US11802153B2 (en) | 2023-10-31 |
| CN111247172B (zh) | 2023-11-14 |
| SI3697817T1 (sl) | 2023-01-31 |
| PT4177270T (pt) | 2024-10-23 |
| ES2989007T3 (es) | 2024-11-25 |
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