CA3078163A1 - Methods of treating heart failure with preserved ejection fraction - Google Patents
Methods of treating heart failure with preserved ejection fraction Download PDFInfo
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- CA3078163A1 CA3078163A1 CA3078163A CA3078163A CA3078163A1 CA 3078163 A1 CA3078163 A1 CA 3078163A1 CA 3078163 A CA3078163 A CA 3078163A CA 3078163 A CA3078163 A CA 3078163A CA 3078163 A1 CA3078163 A1 CA 3078163A1
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201762566668P | 2017-10-02 | 2017-10-02 | |
| US62/566,668 | 2017-10-02 | ||
| PCT/IB2018/057648 WO2019069230A1 (en) | 2017-10-02 | 2018-10-02 | METHODS OF TREATING CARDIAC INSUFFICIENCY WITH PRESERVED EJECTION FRACTION |
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| CA3078163A1 true CA3078163A1 (en) | 2019-04-11 |
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| EP (1) | EP3691650A1 (OSRAM) |
| JP (1) | JP2020536121A (OSRAM) |
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| TW (1) | TW201924689A (OSRAM) |
| WO (1) | WO2019069230A1 (OSRAM) |
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| CN111918655B (zh) | 2018-06-06 | 2024-05-31 | 博希尔公司 | 治疗患有慢性肾脏疾病的糖尿病受试者的方法 |
| KR20210003786A (ko) | 2018-06-14 | 2021-01-12 | 폭셀 | 당뇨병의 치료에서 사용하기 위한 트리아진 유도체를 포함하는 필름 코팅정 |
| CN115770062B (zh) * | 2021-09-07 | 2025-10-10 | 深圳迈瑞生物医疗电子股份有限公司 | 一种超声波数据的处理方法、成像装置 |
| CN116440075B (zh) * | 2023-06-01 | 2025-05-06 | 苏州中化药品工业有限公司 | 一种干混悬剂及其制备方法 |
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| FR2804113B1 (fr) | 2000-01-26 | 2004-06-18 | Lipha | Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique |
| FR2853650B1 (fr) | 2003-04-10 | 2006-07-07 | Merck Sante Sas | Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance |
| FR2896161B1 (fr) | 2006-01-13 | 2008-04-04 | Merck Sante Soc Par Actions Si | Utilisation de derives de triazines pour fabriquer un medicament ayant un effet cicatrisant ou angiogenique. |
| FR2896157B1 (fr) | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agents de stimulation de secretion d'insuline. |
| FR2896159B1 (fr) | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. |
| DE102008007314A1 (de) | 2008-02-02 | 2009-08-06 | Merck Patent Gmbh | Verfahren zur Herstellung von 3,6-Dihydro-1,3,5-triazinderivaten |
| SI2300444T1 (sl) | 2008-05-23 | 2016-10-28 | Poxel Sas | Proces za sintezo derivatov 3,6-dihidro-1,3,5-triazina |
| ES2569105T3 (es) | 2008-07-29 | 2016-05-06 | Poxel | Procedimiento para aislar componentes enantiómeros a partir de mezclas de enantiómeros por cristalización controlada por tamaño de partícula |
| AU2009326965A1 (en) | 2008-12-12 | 2011-06-23 | Poxel | Tetrahydrotriazine compounds for treating diseases associated with AMPK activity |
| EA021395B1 (ru) | 2008-12-12 | 2015-06-30 | Поксель Сас | Комбинация инсулина с триазиновыми производными и их применение для лечения диабета |
| US8742102B2 (en) | 2009-03-26 | 2014-06-03 | Poxel | Process for enantiomeric separation of racemic dihydro-1,3,5 triazines via preferential crystallization |
| FR2948027A1 (fr) | 2009-07-17 | 2011-01-21 | Merck Sante Sas | Derives amines de dihydro-1,3,5-triazine pour leur utilisation dans le traitement des maladies associees a une ischemie et/ou une reperfusion |
| EP2579879B1 (en) | 2010-06-09 | 2016-03-23 | Poxel | Triazine derivatives for delaying the onset of type 1 diabetes |
| TWI436768B (zh) | 2010-06-09 | 2014-05-11 | Poxel | 第２型糖尿病之治療 |
| CN103228635B (zh) | 2010-12-01 | 2016-03-30 | 珀科赛尔 | 利用酒石酸分离三嗪衍生物对映异构体 |
| US9211263B2 (en) | 2012-01-06 | 2015-12-15 | Elcelyx Therapeutics, Inc. | Compositions and methods of treating metabolic disorders |
| WO2014160524A1 (en) * | 2013-03-14 | 2014-10-02 | The Trustees Of The University Of Pennsylvania | Cardio- metabolic and cascular effects of glp-1 metabolites |
| CA2812519A1 (en) | 2013-04-05 | 2014-10-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| EP3110449B1 (en) * | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
| EP3217987A4 (en) | 2014-11-10 | 2018-06-20 | Merck Sharp & Dohme Corp. | Sglt-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease |
| MA43709A (fr) * | 2016-03-16 | 2018-11-28 | Boehringer Ingelheim Int | Composition pharmaceutique comprenant de l'empagliflozine et ses utilisations |
| BR112020006472A2 (pt) | 2017-10-02 | 2020-10-06 | Poxel | método para tratamento ou prevenção de insuficiência cardíaca com fração de ejeção preservada (icfep) |
| CN111918655B (zh) | 2018-06-06 | 2024-05-31 | 博希尔公司 | 治疗患有慢性肾脏疾病的糖尿病受试者的方法 |
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- 2018-10-02 CN CN201880063705.4A patent/CN111163782A/zh active Pending
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Also Published As
| Publication number | Publication date |
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| WO2019069230A1 (en) | 2019-04-11 |
| IL273723A (en) | 2020-05-31 |
| ZA202002292B (en) | 2022-12-21 |
| JP2020536121A (ja) | 2020-12-10 |
| US11617754B2 (en) | 2023-04-04 |
| CN111163782A (zh) | 2020-05-15 |
| EP3691650A1 (en) | 2020-08-12 |
| KR20200102982A (ko) | 2020-09-01 |
| BR112020006472A2 (pt) | 2020-10-06 |
| TW201924689A (zh) | 2019-07-01 |
| US20200316078A1 (en) | 2020-10-08 |
| MX2020003243A (es) | 2020-09-18 |
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