JP2020536121A - 駆出率が保持された心不全を治療する方法 - Google Patents

駆出率が保持された心不全を治療する方法 Download PDF

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JP2020536121A
JP2020536121A JP2020539153A JP2020539153A JP2020536121A JP 2020536121 A JP2020536121 A JP 2020536121A JP 2020539153 A JP2020539153 A JP 2020539153A JP 2020539153 A JP2020539153 A JP 2020539153A JP 2020536121 A JP2020536121 A JP 2020536121A
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imegrimin
patient
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JP2020536121A5 (OSRAM
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アラクウ−ボゼック ソフィー
アラクウ−ボゼック ソフィー
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Poxel SA
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Poxel SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020539153A 2017-10-02 2018-10-02 駆出率が保持された心不全を治療する方法 Pending JP2020536121A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762566668P 2017-10-02 2017-10-02
US62/566,668 2017-10-02
PCT/IB2018/057648 WO2019069230A1 (en) 2017-10-02 2018-10-02 METHODS OF TREATING CARDIAC INSUFFICIENCY WITH PRESERVED EJECTION FRACTION

Publications (2)

Publication Number Publication Date
JP2020536121A true JP2020536121A (ja) 2020-12-10
JP2020536121A5 JP2020536121A5 (OSRAM) 2021-12-02

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JP2020539153A Pending JP2020536121A (ja) 2017-10-02 2018-10-02 駆出率が保持された心不全を治療する方法

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US (1) US11617754B2 (OSRAM)
EP (1) EP3691650A1 (OSRAM)
JP (1) JP2020536121A (OSRAM)
KR (1) KR20200102982A (OSRAM)
CN (1) CN111163782A (OSRAM)
BR (1) BR112020006472A2 (OSRAM)
CA (1) CA3078163A1 (OSRAM)
IL (1) IL273723A (OSRAM)
MX (1) MX2020003243A (OSRAM)
TW (1) TW201924689A (OSRAM)
WO (1) WO2019069230A1 (OSRAM)
ZA (1) ZA202002292B (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020006472A2 (pt) 2017-10-02 2020-10-06 Poxel método para tratamento ou prevenção de insuficiência cardíaca com fração de ejeção preservada (icfep)
CN111918655B (zh) 2018-06-06 2024-05-31 博希尔公司 治疗患有慢性肾脏疾病的糖尿病受试者的方法
KR20210003786A (ko) 2018-06-14 2021-01-12 폭셀 당뇨병의 치료에서 사용하기 위한 트리아진 유도체를 포함하는 필름 코팅정
CN115770062B (zh) * 2021-09-07 2025-10-10 深圳迈瑞生物医疗电子股份有限公司 一种超声波数据的处理方法、成像装置
CN116440075B (zh) * 2023-06-01 2025-05-06 苏州中化药品工业有限公司 一种干混悬剂及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017507956A (ja) * 2014-02-28 2017-03-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用

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FR2804113B1 (fr) 2000-01-26 2004-06-18 Lipha Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique
FR2853650B1 (fr) 2003-04-10 2006-07-07 Merck Sante Sas Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance
FR2896161B1 (fr) 2006-01-13 2008-04-04 Merck Sante Soc Par Actions Si Utilisation de derives de triazines pour fabriquer un medicament ayant un effet cicatrisant ou angiogenique.
FR2896157B1 (fr) 2006-01-13 2008-09-12 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agents de stimulation de secretion d'insuline.
FR2896159B1 (fr) 2006-01-13 2008-09-12 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline.
DE102008007314A1 (de) 2008-02-02 2009-08-06 Merck Patent Gmbh Verfahren zur Herstellung von 3,6-Dihydro-1,3,5-triazinderivaten
SI2300444T1 (sl) 2008-05-23 2016-10-28 Poxel Sas Proces za sintezo derivatov 3,6-dihidro-1,3,5-triazina
ES2569105T3 (es) 2008-07-29 2016-05-06 Poxel Procedimiento para aislar componentes enantiómeros a partir de mezclas de enantiómeros por cristalización controlada por tamaño de partícula
AU2009326965A1 (en) 2008-12-12 2011-06-23 Poxel Tetrahydrotriazine compounds for treating diseases associated with AMPK activity
EA021395B1 (ru) 2008-12-12 2015-06-30 Поксель Сас Комбинация инсулина с триазиновыми производными и их применение для лечения диабета
US8742102B2 (en) 2009-03-26 2014-06-03 Poxel Process for enantiomeric separation of racemic dihydro-1,3,5 triazines via preferential crystallization
FR2948027A1 (fr) 2009-07-17 2011-01-21 Merck Sante Sas Derives amines de dihydro-1,3,5-triazine pour leur utilisation dans le traitement des maladies associees a une ischemie et/ou une reperfusion
EP2579879B1 (en) 2010-06-09 2016-03-23 Poxel Triazine derivatives for delaying the onset of type 1 diabetes
TWI436768B (zh) 2010-06-09 2014-05-11 Poxel 第２型糖尿病之治療
CN103228635B (zh) 2010-12-01 2016-03-30 珀科赛尔 利用酒石酸分离三嗪衍生物对映异构体
US9211263B2 (en) 2012-01-06 2015-12-15 Elcelyx Therapeutics, Inc. Compositions and methods of treating metabolic disorders
WO2014160524A1 (en) * 2013-03-14 2014-10-02 The Trustees Of The University Of Pennsylvania Cardio- metabolic and cascular effects of glp-1 metabolites
CA2812519A1 (en) 2013-04-05 2014-10-05 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
EP3217987A4 (en) 2014-11-10 2018-06-20 Merck Sharp & Dohme Corp. Sglt-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease
MA43709A (fr) * 2016-03-16 2018-11-28 Boehringer Ingelheim Int Composition pharmaceutique comprenant de l'empagliflozine et ses utilisations
BR112020006472A2 (pt) 2017-10-02 2020-10-06 Poxel método para tratamento ou prevenção de insuficiência cardíaca com fração de ejeção preservada (icfep)
CN111918655B (zh) 2018-06-06 2024-05-31 博希尔公司 治疗患有慢性肾脏疾病的糖尿病受试者的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017507956A (ja) * 2014-02-28 2017-03-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用

Non-Patent Citations (3)

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J CLIN MED RES, vol. 10, no. 11, JPN6022030872, 2018, pages 799 - 805, ISSN: 0004838526 *
LACHAUX M; ET AL: "P577 | BENCH: SHORT- AND LONG-TERM IMEGLIMIN TREATMENT REDUCES METABOLIC SYNDROME-RELATED DIABETIC C", EUROPEAN HEART JOURNAL, vol. VOL:38, NR:SUPPL1, JPN5021001821, 29 August 2017 (2017-08-29), GB, pages 101, ISSN: 0005043412 *
LACHAUX, MARIANNE ET AL.: "Short- and long-term imeglimin treatment reduces metabolic syndrome-related diabetic cardiomyopathy", EASD (EUROPEAN ASSOCIATION FOR THE STUDY OF DIABETES) [ONLINE], JPN6022030875, August 2017 (2017-08-01), ISSN: 0005043413 *

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Publication number Publication date
WO2019069230A1 (en) 2019-04-11
IL273723A (en) 2020-05-31
ZA202002292B (en) 2022-12-21
CA3078163A1 (en) 2019-04-11
US11617754B2 (en) 2023-04-04
CN111163782A (zh) 2020-05-15
EP3691650A1 (en) 2020-08-12
KR20200102982A (ko) 2020-09-01
BR112020006472A2 (pt) 2020-10-06
TW201924689A (zh) 2019-07-01
US20200316078A1 (en) 2020-10-08
MX2020003243A (es) 2020-09-18

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