CA3077475A1 - Electronic breath actuated in-line droplet delivery device and methods of use - Google Patents
Electronic breath actuated in-line droplet delivery device and methods of use Download PDFInfo
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- CA3077475A1 CA3077475A1 CA3077475A CA3077475A CA3077475A1 CA 3077475 A1 CA3077475 A1 CA 3077475A1 CA 3077475 A CA3077475 A CA 3077475A CA 3077475 A CA3077475 A CA 3077475A CA 3077475 A1 CA3077475 A1 CA 3077475A1
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- delivery device
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- airflow
- droplet delivery
- mouthpiece
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/587—Lighting arrangements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6054—Magnetic identification systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8237—Charging means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/11—Laminar flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Anesthesiology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762568057P | 2017-10-04 | 2017-10-04 | |
| US62/568,057 | 2017-10-04 | ||
| US201762575165P | 2017-10-20 | 2017-10-20 | |
| US62/575,165 | 2017-10-20 | ||
| US201862622022P | 2018-01-25 | 2018-01-25 | |
| US62/622,022 | 2018-01-25 | ||
| US201862732455P | 2018-09-17 | 2018-09-17 | |
| US62/732,455 | 2018-09-17 | ||
| PCT/US2018/054417 WO2019071008A1 (en) | 2017-10-04 | 2018-10-04 | ELECTRONIC DEVICE FOR DELIVERY OF LINEAR SHAPE ADMINISTRATION OPERATED BY BREATHING AND METHODS OF USE |
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| CA3077475A1 true CA3077475A1 (en) | 2019-04-11 |
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| EP (1) | EP3691728B1 (cg-RX-API-DMAC7.html) |
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| WO (1) | WO2019071008A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017192773A1 (en) | 2016-05-03 | 2017-11-09 | Pneuma Respiratory, Inc. | Methods for treatment of pulmonary lung diseases with improved therapeutic efficacy and improved dose efficiency |
| US11285274B2 (en) | 2016-05-03 | 2022-03-29 | Pneuma Respiratory, Inc. | Methods for the systemic delivery of therapeutic agents to the pulmonary system using a droplet delivery device |
| WO2017192782A1 (en) | 2016-05-03 | 2017-11-09 | Pneuma Respiratory, Inc. | Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment |
| JP6774508B2 (ja) * | 2016-05-03 | 2020-10-28 | ニューマ・リスパイラトリー・インコーポレイテッド | 流体を肺系に供給するための液滴送達装置、及びその使用方法 |
| CN109475709B (zh) | 2016-05-03 | 2022-12-27 | 精呼吸股份有限公司 | 使用液滴输送装置生成液滴并将其输送到肺部系统的方法 |
| EP3634552A4 (en) | 2017-05-19 | 2021-03-03 | Pneuma Respiratory, Inc. | DRY POWDER ADMINISTRATION DEVICE AND METHODS OF USE |
| EP4344719B1 (en) | 2017-10-17 | 2025-12-31 | Pneuma Respiratory, Inc. | NASAL MEDICATION ADMINISTRATION DEVICE |
| US11771852B2 (en) | 2017-11-08 | 2023-10-03 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device with small volume ampoule and methods of use |
| CA3087769A1 (en) * | 2018-01-08 | 2019-07-11 | Pneuma Respiratory, Inc. | Treatment of pulmonary cancers using an electronic breath actuated droplet delivery device |
| US11690963B2 (en) | 2018-08-22 | 2023-07-04 | Qnovia, Inc. | Electronic device for producing an aerosol for inhalation by a person |
| US11517685B2 (en) | 2019-01-18 | 2022-12-06 | Qnovia, Inc. | Electronic device for producing an aerosol for inhalation by a person |
| US12501929B2 (en) | 2018-08-22 | 2025-12-23 | Qnovia, Inc. | Electronic device for producing an aerosol for inhalation by a person |
| EP3829370A4 (en) | 2018-08-22 | 2022-04-27 | Respira Technologies, Inc. | Electronic device for producing an aerosol for inhalation by a person |
| WO2020072478A1 (en) * | 2018-10-01 | 2020-04-09 | Pneuma Respiratory, Inc. | Delivery of low surface tension compositions to the pulmonary system via electronic breath actuated droplet delivery device |
| US20210077753A1 (en) * | 2019-04-01 | 2021-03-18 | Bn Intellectual Properties, Inc. | Nebulizer delivery systems and methods |
| US11406786B2 (en) * | 2019-04-22 | 2022-08-09 | Sunovion Pharmaceuticals Inc. | Nebulizer monitoring device, system and method |
| CA3137375A1 (en) * | 2019-05-03 | 2020-11-12 | Jt International S.A. | Aerosol generation device having a moveable closure with a detector |
| CN114144217A (zh) * | 2019-05-07 | 2022-03-04 | 金德瓦药物控释有限公司 | 警告系统、吸入器和产生警告的方法 |
| JP2022538120A (ja) * | 2019-06-27 | 2022-08-31 | ニューマ・リスパイラトリー・インコーポレイテッド | 電子呼吸作動式液滴送達デバイスによる呼吸器系への小液滴の送達 |
| US11889861B2 (en) | 2019-09-23 | 2024-02-06 | Rai Strategic Holdings, Inc. | Arrangement of atomization assemblies for aerosol delivery device |
| EP3967347B1 (de) * | 2020-09-09 | 2023-05-31 | Pulmotree Medical GmbH | Vernebler |
| US20230390507A1 (en) * | 2020-10-16 | 2023-12-07 | Vectura Delivery Devices Limited | Method for detecting the presence of liquid in a vibrating membrane nebulizer |
| US12471625B2 (en) | 2020-11-01 | 2025-11-18 | Qnovia, Inc. | Electronic devices and liquids for aerosolizing and inhaling therewith |
| US11969545B2 (en) | 2020-12-01 | 2024-04-30 | Rai Strategic Holdings, Inc. | Liquid feed systems for an aerosol delivery device |
| US11793945B2 (en) | 2021-06-22 | 2023-10-24 | Pneuma Respiratory, Inc. | Droplet delivery device with push ejection |
| TW202404490A (zh) | 2022-04-22 | 2024-02-01 | 美商奎諾維亞公司 | 用於霧化和吸入液體的電子設備 |
| WO2024020041A1 (en) | 2022-07-18 | 2024-01-25 | Pneuma Respiratory, Inc. | Small step size and high resolution aerosol generation system and method |
| WO2025129612A1 (en) * | 2023-12-22 | 2025-06-26 | Imperial Tobacco Limited | Aerosol generating apparatus |
| CN120287550B (zh) * | 2025-06-13 | 2025-08-19 | 西安高达新材料科技有限公司 | 一种聚酯型抗静电粉末涂料的制备方法 |
Family Cites Families (268)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3934585A (en) | 1970-08-13 | 1976-01-27 | Maurice David M | Method and apparatus for application of eye drops |
| DE2445791C2 (de) | 1974-09-25 | 1984-04-19 | Siemens AG, 1000 Berlin und 8000 München | Ultraschall-Flüssigkeitszerstäuber |
| US5021701A (en) | 1988-10-20 | 1991-06-04 | Tdk Corporation | Piezoelectric vibrator mounting system for a nebulizer |
| US5487378A (en) * | 1990-12-17 | 1996-01-30 | Minnesota Mining And Manufacturing Company | Inhaler |
| US5404871A (en) | 1991-03-05 | 1995-04-11 | Aradigm | Delivery of aerosol medications for inspiration |
| US7628339B2 (en) | 1991-04-24 | 2009-12-08 | Novartis Pharma Ag | Systems and methods for controlling fluid feed to an aerosol generator |
| US5164740A (en) | 1991-04-24 | 1992-11-17 | Yehuda Ivri | High frequency printing mechanism |
| US5938117A (en) | 1991-04-24 | 1999-08-17 | Aerogen, Inc. | Methods and apparatus for dispensing liquids as an atomized spray |
| US5363842A (en) | 1991-12-20 | 1994-11-15 | Circadian, Inc. | Intelligent inhaler providing feedback to both patient and medical professional |
| JP2546439B2 (ja) | 1992-04-09 | 1996-10-23 | オムロン株式会社 | 超音波霧化装置,超音波式吸入器およびその制御方法 |
| GB2272389B (en) | 1992-11-04 | 1996-07-24 | Bespak Plc | Dispensing apparatus |
| US5888477A (en) | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
| US5607410A (en) | 1993-02-16 | 1997-03-04 | Branch; John D. | Vision directed eye wash |
| US5497763A (en) | 1993-05-21 | 1996-03-12 | Aradigm Corporation | Disposable package for intrapulmonary delivery of aerosolized formulations |
| CN100566769C (zh) | 1993-06-29 | 2009-12-09 | 茵捷特数码浮质有限公司 | 利用吸入方式服用物质的方法和器具 |
| DE69430196T2 (de) | 1993-06-29 | 2002-10-31 | Ponwell Enterprises Ltd., Hongkong | Spender |
| GB9405952D0 (en) | 1994-03-25 | 1994-05-11 | Zeneca Ltd | Aqueous ophthalmic sprays |
| US5522385A (en) | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
| EP0789629A1 (en) | 1994-11-02 | 1997-08-20 | Danmist ApS | A method and device for atomizing fluids |
| US6011062A (en) | 1994-12-22 | 2000-01-04 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| US20020121274A1 (en) * | 1995-04-05 | 2002-09-05 | Aerogen, Inc. | Laminated electroformed aperture plate |
| US5586550A (en) | 1995-08-31 | 1996-12-24 | Fluid Propulsion Technologies, Inc. | Apparatus and methods for the delivery of therapeutic liquids to the respiratory system |
| US5758637A (en) | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
| US6085740A (en) | 1996-02-21 | 2000-07-11 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
| IL122494A (en) | 1995-06-21 | 2001-08-08 | Asta Medica Ag | A cartridge for pharmaceutical powder with a measuring device and an integral inhaler for powdered medicines |
| US5828394A (en) | 1995-09-20 | 1998-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Fluid drop ejector and method |
| DE19535010C2 (de) | 1995-09-21 | 1998-01-22 | Pelikan Produktions Ag | Verwendung eines Tropfenerzeugers in einem medizinischen Gerät zum dosierten Zuführen eines Medikamentes zu einem Fluidstrom |
| US5823179A (en) | 1996-02-13 | 1998-10-20 | 1263152 Ontario Inc. | Nebulizer apparatus and method |
| IL118191A (en) | 1996-05-08 | 2001-04-30 | Card Guard Scient Survival Ltd | System and method for remote respiratory examination |
| US5997642A (en) | 1996-05-21 | 1999-12-07 | Symetrix Corporation | Method and apparatus for misted deposition of integrated circuit quality thin films |
| JP3557595B2 (ja) | 1996-10-22 | 2004-08-25 | 日本光電工業株式会社 | フローセンサ |
| US5906202A (en) * | 1996-11-21 | 1999-05-25 | Aradigm Corporation | Device and method for directing aerosolized mist to a specific area of the respiratory tract |
| JPH1142219A (ja) | 1997-07-28 | 1999-02-16 | Omron Corp | 肺活量測定装置 |
| DE69802252T2 (de) | 1997-11-19 | 2002-07-04 | Microflow Engineering S.A., Neuenburg/Neuchatel | Tröpfchen-Vernebler und Zerstäubungsdüse für einen therapeutischen Inhalator |
| US6358058B1 (en) | 1998-01-30 | 2002-03-19 | 1263152 Ontario Inc. | Aerosol dispensing inhaler training device |
| US6158431A (en) | 1998-02-13 | 2000-12-12 | Tsi Incorporated | Portable systems and methods for delivery of therapeutic material to the pulmonary system |
| US6257234B1 (en) | 1998-08-21 | 2001-07-10 | Respironics, Inc. | Apparatus and method for determining respiratory mechanics of a patient and for controlling a ventilator based thereon |
| US6397838B1 (en) | 1998-12-23 | 2002-06-04 | Battelle Pulmonary Therapeutics, Inc. | Pulmonary aerosol delivery device and method |
| US6378780B1 (en) | 1999-02-09 | 2002-04-30 | S. C. Johnson & Son, Inc. | Delivery system for dispensing volatiles |
| US6196218B1 (en) | 1999-02-24 | 2001-03-06 | Ponwell Enterprises Ltd | Piezo inhaler |
| US6615826B1 (en) | 1999-02-26 | 2003-09-09 | 3M Innovative Properties Company | Slow spray metered dose inhaler |
| WO2000053337A1 (en) | 1999-03-08 | 2000-09-14 | S. C. Johnson & Son, Inc. | Improved attachment method for piezoelectric elements |
| US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
| PE20010720A1 (es) | 1999-12-11 | 2001-07-26 | Glaxo Group Ltd | Distribuidor de medicamento |
| JP4777574B2 (ja) | 2000-02-11 | 2011-09-21 | レスピロニクス・レスピラトリー・ドラッグ・デリバリー・(ユーケー)・リミテッド | 薬剤投与装置 |
| US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
| MXPA02010884A (es) * | 2000-05-05 | 2003-03-27 | Aerogen Ireland Ltd | Aparato y metodo para el suministro de medicamentos al sistema respiratorio. |
| US7971588B2 (en) * | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
| US7600511B2 (en) | 2001-11-01 | 2009-10-13 | Novartis Pharma Ag | Apparatus and methods for delivery of medicament to a respiratory system |
| WO2001087378A2 (en) | 2000-05-12 | 2001-11-22 | Dura Pharmaceuticals, Inc. | Compressed gas dry powder inhaler |
| US6637430B1 (en) | 2000-06-16 | 2003-10-28 | Ponwell Enterprises Limited | Respiratory delivery system with power/medicament recharge assembly |
| US6629524B1 (en) | 2000-07-12 | 2003-10-07 | Ponwell Enterprises Limited | Inhaler |
| HK1056125A1 (zh) | 2000-07-15 | 2004-02-06 | Glaxo Group Limited | 藥劑分配器 |
| WO2002009669A2 (en) | 2000-08-01 | 2002-02-07 | Inhale Therapeutic Systems, Inc. | Apparatus and process to produce particles having a narrow size distribution and particles made thereby |
| US7121275B2 (en) * | 2000-12-18 | 2006-10-17 | Xerox Corporation | Method of using focused acoustic waves to deliver a pharmaceutical product |
| ATE502623T1 (de) | 2000-12-27 | 2011-04-15 | Gilead Sciences Inc | Inhalierbares aztreonam zur behandlung und vorbeugung von bakteriellen lungeninfektionen |
| US6758837B2 (en) | 2001-02-08 | 2004-07-06 | Pharmacia Ab | Liquid delivery device and method of use thereof |
| US20030072717A1 (en) | 2001-02-23 | 2003-04-17 | Vapotronics, Inc. | Inhalation device having an optimized air flow path |
| US6732944B2 (en) | 2001-05-02 | 2004-05-11 | Aerogen, Inc. | Base isolated nebulizing device and methods |
| KR20020087298A (ko) | 2001-05-15 | 2002-11-22 | 김원규 | 야생삼을 주성분으로 함유하는 자양강장용 조성물 |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| WO2003020349A2 (en) | 2001-08-31 | 2003-03-13 | Rosti A/S | Inhaler |
| JP2003159332A (ja) | 2001-11-27 | 2003-06-03 | Omron Corp | ネブライザ、サーバ、ネブライザシステム、ネブライザにおける薬剤判別方法、ネブライザにおける薬量検出方法、ネブライザシステムにおける情報管理方法、ネブライザ情報管理プログラム、および該プログラムを記録する記録媒体 |
| US6684880B2 (en) | 2001-12-04 | 2004-02-03 | Hewlett-Packard Development Company, L.P. | Applicator for dispensing bioactive compositions and methods for using the same |
| US6851626B2 (en) | 2002-01-07 | 2005-02-08 | Aerogen, Inc. | Methods and devices for nebulizing fluids |
| US7458373B2 (en) | 2002-01-15 | 2008-12-02 | Philip Morris Usa Inc. | Aerosol generator for drug formulation |
| WO2003059424A1 (en) | 2002-01-15 | 2003-07-24 | Aerogen, Inc. | Methods and systems for operating an aerosol generator |
| JP2003265994A (ja) | 2002-03-13 | 2003-09-24 | Olympus Optical Co Ltd | 噴霧ヘッド |
| WO2003079993A2 (en) | 2002-03-20 | 2003-10-02 | Advanced Inhalation Research, Inc. | hGH (HUMAN GROWTH HORMONE) FORMULATIONS FOR PULMONARY ADMINISTRATION |
| ES2382038T3 (es) | 2002-04-19 | 2012-06-04 | 3M Innovative Properties Company | Un separador o dispositivo de accionamiento para la eliminación inercial de la fracción no respirable de aerosoles medicinales |
| JP2006507921A (ja) | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
| JP4719465B2 (ja) | 2002-09-04 | 2011-07-06 | ディーエスエム アイピー アセッツ ビー.ブイ. | インスリン感受性増強剤およびペプチド画分を含む栄養補給用および治療用組成物 |
| US7070071B2 (en) | 2002-09-23 | 2006-07-04 | Agouron Pharmaceuticals, Inc. | Dispensing apparatus and method for liquid products, particularly medicinal products |
| DE10244795A1 (de) | 2002-09-26 | 2004-04-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator |
| US20040230090A1 (en) | 2002-10-07 | 2004-11-18 | Hegde Anant V. | Vascular assist device and methods |
| US6886557B2 (en) | 2002-10-31 | 2005-05-03 | Hewlett-Packard Development Company, L.P. | Inhalation device and method for delivering variable amounts of different components |
| GB2396825B (en) * | 2002-11-20 | 2004-12-08 | Profile Respiratory Systems Lt | Improved inhalation method and apparatus |
| US7849850B2 (en) | 2003-02-28 | 2010-12-14 | Battelle Memorial Institute | Nozzle for handheld pulmonary aerosol delivery device |
| US8545463B2 (en) | 2003-05-20 | 2013-10-01 | Optimyst Systems Inc. | Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device |
| WO2004103478A1 (en) | 2003-05-20 | 2004-12-02 | Collins James F | Ophthalmic drug delivery system |
| US8616195B2 (en) | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
| JP4411901B2 (ja) | 2003-08-11 | 2010-02-10 | セイコーエプソン株式会社 | 霧化装置 |
| US20050172958A1 (en) | 2003-08-20 | 2005-08-11 | The Brigham And Women's Hospital, Inc. | Inhalation device and system for the remote monitoring of drug administration |
| US20050133024A1 (en) | 2003-11-25 | 2005-06-23 | Coifman Robert E. | Devices for measuring inspiratory airflow |
| US20050121025A1 (en) | 2003-12-04 | 2005-06-09 | Gamard Stephan C.F. | Portable gas operating inhaler |
| US20050150489A1 (en) | 2004-01-12 | 2005-07-14 | Steve Dunfield | Dispensing medicaments based on rates of medicament action |
| US9022027B2 (en) | 2004-02-20 | 2015-05-05 | Pneumoflex Systems, Llc | Nebulizer with intra-oral vibrating mesh |
| US8109266B2 (en) | 2004-02-20 | 2012-02-07 | Pneumoflex Systems, Llc | Nebulizer having flow meter function |
| RU2372105C2 (ru) | 2004-02-24 | 2009-11-10 | Майкродоуз Текнолоджиз, Инк. | Ингалятор с направленным датчиком потока |
| EP1737517B1 (en) | 2004-04-02 | 2010-10-06 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services | Aerosol delivery systems |
| US8056556B2 (en) | 2004-04-12 | 2011-11-15 | Hewlett-Packard Development Company, L.P. | Inhaler nozzle maintenance apparatus and method |
| US20080059228A1 (en) | 2004-04-24 | 2008-03-06 | Christopher Bossi | Operation Of A Remote Medication Management System |
| RU2362593C2 (ru) | 2004-08-02 | 2009-07-27 | Кэнон Кабусики Кайся | Ингаляционное устройство (варианты) |
| JP4695940B2 (ja) | 2004-08-02 | 2011-06-08 | キヤノン株式会社 | 吸入装置 |
| ES2314354T3 (es) | 2004-11-09 | 2009-03-16 | Novagali Pharma S.A. | Emulsion de tipo aceite en agua con baja concentracion de agente cationico y potencial zeta positivo. |
| GB0427858D0 (en) | 2004-12-20 | 2005-01-19 | Glaxo Group Ltd | Manifold for use in medicament dispenser |
| US8361026B2 (en) | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
| JP2006212203A (ja) | 2005-02-03 | 2006-08-17 | Canon Inc | 吸入装置、及び液剤吐出カートリッジ |
| DE102005006374B3 (de) | 2005-02-11 | 2006-07-20 | Pari GmbH Spezialisten für effektive Inhalation | Aerosolerzeugungsvorrichtung und Inhalationstherapiegerät mit einer derartigen Vorrichtung |
| CN101151060B (zh) | 2005-03-30 | 2010-05-19 | 佳能株式会社 | 药液喷射装置 |
| DE102005016100B3 (de) | 2005-04-08 | 2006-10-26 | Altana Pharma Ag | Vorrichtung zur Dosierung und Trockenvernebelung |
| US7219664B2 (en) | 2005-04-28 | 2007-05-22 | Kos Life Sciences, Inc. | Breath actuated inhaler |
| JP5087539B2 (ja) | 2005-05-18 | 2012-12-05 | ネクター セラピューティックス | 気管支内治療のためのバルブ、デバイス、および方法 |
| EA012656B1 (ru) | 2005-05-25 | 2009-12-30 | Аэроджен, Инк. | Вибрационные системы и их применение |
| WO2007008825A2 (en) | 2005-07-11 | 2007-01-18 | Emory University | System and method for optimized delivery of an aerosol to the respiratory tract |
| IL169807A (en) | 2005-07-21 | 2015-03-31 | Steadymed Ltd | Device for administering a drug |
| US8367734B1 (en) | 2005-08-11 | 2013-02-05 | Amphastar Pharmaceuticals Inc. | Stable epinephrine suspension formulation with high inhalation delivery efficiency |
| US7900625B2 (en) | 2005-08-26 | 2011-03-08 | North Carolina State University | Inhaler system for targeted maximum drug-aerosol delivery |
| KR100802149B1 (ko) | 2005-09-16 | 2008-02-11 | 주식회사 진생사이언스 | 혈관 손상에 의한 질환 예방 및 치료용 조성물 |
| EP1937337A1 (en) | 2005-10-18 | 2008-07-02 | EQUINE NEBULIZER ApS | Inhalation device for providing a mist of nebulised liquid medical solution to a user |
| US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| DE102006006183A1 (de) * | 2006-02-10 | 2007-08-16 | Pari GmbH Spezialisten für effektive Inhalation | Inhalationstherapievorrichtung für die Anwendung bei Frühgeborenen und Kleinkindern |
| US20100154794A1 (en) | 2006-03-21 | 2010-06-24 | Valentin Boris N | Inhaler Flow Channel |
| US7841338B2 (en) | 2006-04-13 | 2010-11-30 | Boehringer Ingelheim International Gmbh | Dispensing device |
| US20090114218A1 (en) | 2006-04-13 | 2009-05-07 | Ada Technologies, Inc. | Electrotherapeutic treatment device and method |
| US8376525B2 (en) | 2006-09-08 | 2013-02-19 | Canon Kabushiki Kaisha | Liquid discharge head and method of manufacturing the same |
| US20080142010A1 (en) | 2006-09-20 | 2008-06-19 | Next Safety, Inc. | Systems, methods, and apparatuses for pulmonary drug delivery |
| NL2000309C2 (nl) | 2006-11-09 | 2008-05-13 | Indes Holding Bv | Systeem voor het kunstmatig beademen van personen. |
| FR2908329B1 (fr) | 2006-11-14 | 2011-01-07 | Telemaq | Dispositif et methode de distribution de fluide par ultrasons |
| US8196576B2 (en) * | 2007-02-28 | 2012-06-12 | Microdose Therapeutx, Inc. | Inhaler |
| WO2008116165A2 (en) | 2007-03-21 | 2008-09-25 | Next Safety, Inc. | Methods and systems of delivering medication via inhalation |
| JP4877011B2 (ja) | 2007-03-28 | 2012-02-15 | ブラザー工業株式会社 | 液滴噴射装置 |
| US20090235925A1 (en) | 2007-03-28 | 2009-09-24 | John Sylvester Power | Aerosolisation system |
| EP2139409A1 (en) | 2007-03-28 | 2010-01-06 | Stamford Devices Limited | Insufflation of body cavities |
| US20080271732A1 (en) | 2007-05-01 | 2008-11-06 | Next Safety, Inc. | Pulmonary Drug Delivery Devices Configured to Control the Size of Administered Droplets |
| EP1992380A1 (en) | 2007-05-16 | 2008-11-19 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device |
| US8528544B2 (en) | 2007-05-30 | 2013-09-10 | Canon Kabushiki Kaisha | Inhaler |
| AU2008305591A1 (en) | 2007-09-25 | 2009-04-02 | Nektar Therapeutics | Treatment of pulmonary disorders with aerosolized medicaments such as vancomycin |
| AU2012258488A1 (en) | 2007-09-25 | 2013-01-10 | Nektar Therapeutics | Treatment of pulmonary disorders with aerosolized medicaments such as vancomycin |
| EP2214660A2 (en) | 2007-10-12 | 2010-08-11 | Resolvyx Pharmaceuticals, Inc. | Omega-3 fatty acids, hydroxy polyunsaturated fatty acids, lipoxin compounds, or oxylipin compounds for the treatment of ophthalmic conditions |
| JP2009106467A (ja) | 2007-10-30 | 2009-05-21 | Canon Inc | 吸入装置 |
| US20090212133A1 (en) | 2008-01-25 | 2009-08-27 | Collins Jr James F | Ophthalmic fluid delivery device and method of operation |
| WO2009111612A1 (en) | 2008-03-07 | 2009-09-11 | Novartis Ag | Aerosolization device |
| DK2285439T3 (en) * | 2008-04-04 | 2014-03-24 | Nektar Therapeutics | Aerosoliseringsanorning |
| US7891580B2 (en) | 2008-04-30 | 2011-02-22 | S.C. Johnson & Son, Inc. | High volume atomizer for common consumer spray products |
| RU2470681C2 (ru) | 2008-06-20 | 2012-12-27 | Маннкайнд Корпорейшн | Интерактивное устройство и способ профилирования усилий при ингаляции в реальном масштабе времени |
| US8517010B2 (en) | 2008-09-26 | 2013-08-27 | Stamford Devices Limited | Nebuliser system |
| PL2337600T3 (pl) | 2008-09-26 | 2020-04-30 | Stamford Devices Limited | System podawania tlenu uzupełniającego |
| US20090192443A1 (en) | 2008-10-06 | 2009-07-30 | Collins Jr James F | Ophthalmic fluid delivery device and method of operation |
| CN104856679B (zh) | 2008-12-01 | 2019-02-22 | 创控科技股份有限公司 | 用于哮喘、肺结核及肺癌诊断及疾病管控的呼吸分析系统及方法 |
| EP2373367B1 (en) * | 2008-12-02 | 2015-10-21 | Qool Therapeutics, Inc. | Systems and methods for delivery of a breathing gas with fine ice particles |
| DE102008054431B3 (de) | 2008-12-09 | 2010-06-17 | Pari Pharma Gmbh | Aerosoltherapievorrichtung |
| JP2010143048A (ja) | 2008-12-18 | 2010-07-01 | Fuji Xerox Co Ltd | 液滴吐出ヘッドおよび液滴吐出装置 |
| WO2010078428A1 (en) | 2008-12-30 | 2010-07-08 | Optimyst Systems, Inc. | Ophthalmic fluid delivery system |
| JP5801794B2 (ja) | 2009-04-28 | 2015-10-28 | ジネルバ ファーマシューティカルズ, インコーポレイティド | カンナビジオールの製剤及びその使用方法 |
| AU2010246984A1 (en) | 2009-05-11 | 2012-01-19 | Koninklijke Philips Electronics N.V. | Aerosol drug delivery apparatus and method |
| WO2011039638A2 (en) | 2009-10-02 | 2011-04-07 | Foamix Ltd. | Topical tetracycline compositions |
| EP3117859B1 (en) | 2009-10-09 | 2020-07-15 | Philip Morris Products S.a.s. | Aerosol generator including multi-component wick |
| US8596263B2 (en) * | 2009-11-16 | 2013-12-03 | Samuel David Piper | Inhalation actuated nebulizer with impingement shield |
| EP2501492B1 (en) | 2009-11-18 | 2019-12-25 | Reckitt Benckiser LLC | Ultrasonic surface treatment device and method |
| US20100181387A1 (en) * | 2009-12-01 | 2010-07-22 | Zaffaroni Alejandro C | Aerosol delivery system and uses thereof |
| US10173019B2 (en) | 2009-12-26 | 2019-01-08 | Inspiro Medical Ltd. | Dry powder delivery device |
| US9352107B2 (en) | 2010-01-07 | 2016-05-31 | Koninklijke Philips N.V. | Respiratory drug delivery apparatus including a feedback and compliance device |
| CN102971755A (zh) | 2010-01-21 | 2013-03-13 | 阿斯玛西格诺斯公司 | 用于慢性病管理的早期告警方法和系统 |
| US20110230820A1 (en) | 2010-03-18 | 2011-09-22 | Aerosurgical Limited | Insufflation of body cavities |
| WO2011127669A1 (zh) | 2010-04-14 | 2011-10-20 | Lee Jui-Jen | 雾化清洗保健装置及其雾化方法 |
| US20110253139A1 (en) | 2010-04-15 | 2011-10-20 | Spectrum Health Innovations, LLC | Inhaler module and related system |
| US10159278B2 (en) | 2010-05-15 | 2018-12-25 | Rai Strategic Holdings, Inc. | Assembly directed airflow |
| JP6385673B2 (ja) | 2010-06-21 | 2018-09-05 | マンカインド コーポレイション | 乾燥粉末薬物送達システム |
| KR20170129298A (ko) | 2010-07-15 | 2017-11-24 | 아이노비아 인코포레이티드 | 안과용 약물 전달 |
| EP2593055A1 (en) | 2010-07-15 | 2013-05-22 | Corinthian Ophthalmic, Inc. | Method and system for performing remote treatment and monitoring |
| US10154923B2 (en) | 2010-07-15 | 2018-12-18 | Eyenovia, Inc. | Drop generating device |
| ES2835886T3 (es) | 2010-07-15 | 2021-06-23 | Eyenovia Inc | Dispositivo generador de gotas |
| EP3950028B1 (en) | 2010-08-23 | 2024-08-07 | Darren Rubin | Systems of aerosol delivery with airflow regulation |
| US9757528B2 (en) | 2010-08-23 | 2017-09-12 | Darren Rubin | Nebulizer having different negative pressure threshold settings |
| GB201018796D0 (en) | 2010-11-08 | 2010-12-22 | British American Tobacco Co | Aerosol generator |
| AU2011328332A1 (en) | 2010-11-08 | 2013-05-23 | British American Tobacco (Investments) Limited | Liquid droplet spray device |
| EP2457609A1 (en) | 2010-11-24 | 2012-05-30 | PARI Pharma GmbH | Aerosol generator |
| EP3437872B1 (en) * | 2010-12-28 | 2020-12-09 | Stamford Devices Limited | Photodefined aperture plate and method for producing the same |
| US9452274B2 (en) | 2011-01-20 | 2016-09-27 | Pneumoflex Systems, Llc | Metered dose atomizer |
| CN106730186B (zh) | 2011-09-07 | 2020-06-09 | 康森特里克斯药物公司 | 干粉吸入装置 |
| HK1201037A1 (en) | 2011-09-20 | 2015-08-21 | Isonea Limited | Systems, methods and kits for measuring respiratory rate and dynamically predicting respiratory episodes |
| JP5652790B2 (ja) | 2011-09-22 | 2015-01-14 | オムロンヘルスケア株式会社 | 液体噴霧装置 |
| US20130150812A1 (en) | 2011-12-12 | 2013-06-13 | Corinthian Ophthalmic, Inc. | High modulus polymeric ejector mechanism, ejector device, and methods of use |
| JP6368247B2 (ja) | 2011-12-21 | 2018-08-01 | スタムフォード・ディバイセズ・リミテッド | エーロゾル発生装置 |
| US10046121B2 (en) | 2011-12-27 | 2018-08-14 | Vectura Gmbh | Inhalation device with feedback system |
| EP2724741B1 (en) | 2012-10-26 | 2017-06-14 | Vectura GmbH | Inhalation device for use in aerosol therapy |
| WO2014124699A1 (en) | 2012-02-27 | 2014-08-21 | Laerdal Global Health As | Resuscitation assembly with peep valve |
| IN2014DN08290A (cg-RX-API-DMAC7.html) | 2012-03-09 | 2015-05-15 | Vectura Gmbh | |
| EP2836306B1 (en) | 2012-04-10 | 2018-04-04 | Eyenovia, Inc. | Spray ejector mechanisms and devices providing charge isolation and controllable droplet charge, and low dosage volume opthalmic administration |
| US20130269694A1 (en) | 2012-04-16 | 2013-10-17 | Dance Pharmaceuticals, Inc. | Inhaler controlled by mobile device |
| AU2013249108A1 (en) | 2012-04-20 | 2014-12-04 | Eyenovia, Inc. | Spray ejector device and methods of use |
| WO2013163527A1 (en) | 2012-04-27 | 2013-10-31 | Medstar Health | System and method for treating a medical condition using an aerosolized solution |
| CA2873276A1 (en) | 2012-05-14 | 2013-11-21 | Eyenovia, Inc. | Laminar flow droplet generator device and methods of use |
| EA201492094A1 (ru) | 2012-05-15 | 2015-04-30 | Айновиа, Инк. | Эжекторные устройства, способы, возбудители и схемы для них |
| CA2870860C (en) | 2012-05-21 | 2021-07-27 | Insmed Incorporated | Systems for treating pulmonary infections |
| WO2013177621A1 (en) | 2012-05-30 | 2013-12-05 | Resmed Sensor Technologies Limited | Method and apparatus for monitoring cardio-pulmonary health |
| JP2015517865A (ja) * | 2012-05-30 | 2015-06-25 | コーニンクレッカ フィリップス エヌ ヴェ | ポータブル手持ち式混合気体富化圧力支援システム及び方法 |
| RU2637737C2 (ru) | 2012-06-11 | 2017-12-06 | Стэмфорд Девайсиз Лимитед | Способ изготовления дырчатой пластины для распылителя |
| JP6438393B2 (ja) * | 2012-08-13 | 2018-12-12 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 薬物送達及び気体供給を含む手持ち式呼吸困難治療装置 |
| EP2914320B1 (en) | 2012-10-31 | 2019-12-04 | Inhaletech LLC | Systems for administering pulmonary medication |
| EP2925395B1 (en) | 2012-11-28 | 2019-03-06 | Fontem Holdings 1 B.V. | Device for generating a condensation aerosol from a liquid formulation |
| JP6620085B2 (ja) | 2013-03-21 | 2019-12-11 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 呼吸薬剤供給デバイスの使用をモニタリングするシステム及び方法 |
| US8807131B1 (en) | 2013-06-18 | 2014-08-19 | Isonea Limited | Compliance monitoring for asthma inhalers |
| EP3016708A4 (en) | 2013-07-03 | 2017-03-08 | MEway Pharma Ltd. | Metered dose inhaler and methods thereof |
| WO2015005958A1 (en) | 2013-07-09 | 2015-01-15 | Pulmone Advanced Medical Devices, Ltd. | Determining respiratory parameters |
| CN105377346B (zh) | 2013-07-09 | 2020-10-30 | 皇家飞利浦有限公司 | 在呼吸药物递送设备中通过指示流量变化的超声测量结果来监测呼吸参数 |
| WO2016049066A1 (en) | 2014-09-23 | 2016-03-31 | Oscillari Llc | Vibration sensor based drug delivery monitor |
| EP3022548B1 (en) | 2013-07-16 | 2025-04-23 | Freespira, Inc. | Methods and systems for quantitative colorimetric capnometry |
| WO2015042412A1 (en) | 2013-09-20 | 2015-03-26 | E-Nicotine Technology. Inc. | Devices and methods for modifying delivery devices |
| TW201511782A (zh) | 2013-09-30 | 2015-04-01 | Healthkare Entpr Co Ltd | 拋棄式保健器物之結構 |
| WO2015066562A2 (en) | 2013-10-31 | 2015-05-07 | Knox Medical Diagnostics | Systems and methods for monitoring respiratory function |
| EP3068244A4 (en) | 2013-11-15 | 2017-07-05 | VMR Products, LLC | Vaporizer with cover sleeve |
| RU2675912C1 (ru) | 2013-12-19 | 2018-12-25 | Конинклейке Филипс Н.В. | Устройство для применения в жидкостном капельном аппарате |
| AU2015204558B2 (en) | 2014-01-10 | 2020-04-30 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| WO2015114139A1 (en) | 2014-01-31 | 2015-08-06 | Eye-Go Labs Aps | A device for applying an ophthalmic fluid |
| US10709173B2 (en) | 2014-02-06 | 2020-07-14 | Juul Labs, Inc. | Vaporizer apparatus |
| EP2910268A1 (en) | 2014-02-25 | 2015-08-26 | PARI Pharma GmbH | Inhalator and inhalator set |
| NO2709641T3 (cg-RX-API-DMAC7.html) | 2014-03-10 | 2018-05-12 | ||
| CA2949121A1 (en) | 2014-05-15 | 2015-11-19 | Bristol-Myers Squibb Company | Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
| US10610651B2 (en) | 2014-06-09 | 2020-04-07 | Aerami Therapeutics, Inc. | Self-puncturing liquid drug cartridges and associated dispenser |
| WO2015193871A1 (en) * | 2014-06-16 | 2015-12-23 | MEway Pharma LTD | A novel operated nebulizer and means thereof |
| JP6747988B2 (ja) | 2014-06-30 | 2020-08-26 | サイケ メディカル リミテッドSyqe Medical Ltd. | 活性薬剤肺送達のための方法、装置及びシステム |
| JP6980388B2 (ja) | 2014-06-30 | 2021-12-15 | サイケ メディカル リミテッドSyqe Medical Ltd. | 気流調節吸入装置 |
| EP3160565B1 (en) | 2014-06-30 | 2021-08-18 | Syqe Medical Ltd. | Devices and systems for pulmonary delivery of active agents |
| US10857313B2 (en) | 2014-07-01 | 2020-12-08 | Aerami Therapeutics, Inc. | Liquid nebulization systems and methods |
| US11273271B2 (en) * | 2014-07-01 | 2022-03-15 | Aerami Therapeutics, Inc. | Aerosolization system with flow restrictor and feedback device |
| US10471222B2 (en) * | 2014-07-01 | 2019-11-12 | Dance Biopharm Inc. | Aerosolization system with flow restrictor and feedback device |
| FR3023735B1 (fr) | 2014-07-17 | 2016-07-29 | Areco Finances Et Tech - Arfitec | Nebuliseur compact pour rafraichir l'air |
| CN112891688A (zh) | 2014-08-28 | 2021-06-04 | 诺顿(沃特福特)有限公司 | 吸入器的依从性辅助模块 |
| US11033694B2 (en) | 2014-09-22 | 2021-06-15 | Koninklijke Philips N.V. | Inhaler with orientation sensor |
| SI3204095T1 (sl) | 2014-10-10 | 2019-08-30 | Ablynx N.V. | Inhalacijska naprava za uporabo pri zdravljenju bolezni dihal z aerosolom |
| RU2017115670A (ru) | 2014-10-10 | 2018-11-15 | Аблинкс Н.В. | Лечение инфекции рсв |
| CN104586396B (zh) | 2014-12-12 | 2017-04-26 | 歌尔股份有限公司 | 一种肺活量的测试方法和设备 |
| JP6531183B2 (ja) | 2015-01-23 | 2019-06-12 | タン、ウィリアム | 超音波気化素子 |
| US20160325055A1 (en) | 2015-05-08 | 2016-11-10 | Lunatech, Llc | Device To Deliver Cannabidiol And Associated Compounds To Promote Health |
| JP6818008B2 (ja) | 2015-07-20 | 2021-01-20 | パール セラピューティクス,インコーポレイテッド | エアロゾル送達システムおよび関連する方法 |
| CN205019058U (zh) | 2015-07-31 | 2016-02-10 | 天津信仁科技发展有限公司 | 一种基于云平台的肺功能检测训练数据服务系统 |
| US10664572B2 (en) | 2015-08-06 | 2020-05-26 | Microsoft Technology Licensing, Llc | Recommendations for health benefit resources |
| CN204995458U (zh) | 2015-09-15 | 2016-01-27 | 南京瀚雅健康科技有限公司 | 运动心肺测试仪 |
| WO2017056103A1 (en) | 2015-10-01 | 2017-04-06 | Anuraag Reddy Kuchukulla | A controlled nicotine delivery system which restricts, and gradually attenuates the dosage |
| US9352108B1 (en) * | 2015-10-15 | 2016-05-31 | George Ashford Reed | Respiratory medicament nebulizer system |
| US10328218B2 (en) | 2015-10-15 | 2019-06-25 | Engineered Medical Systems, Inc. | Respiratory medicament nebulizer system |
| CN109475709B (zh) | 2016-05-03 | 2022-12-27 | 精呼吸股份有限公司 | 使用液滴输送装置生成液滴并将其输送到肺部系统的方法 |
| CN109414178B (zh) | 2016-05-03 | 2022-05-31 | 精呼吸股份有限公司 | 用于肺部健康管理的系统和方法 |
| WO2017192773A1 (en) | 2016-05-03 | 2017-11-09 | Pneuma Respiratory, Inc. | Methods for treatment of pulmonary lung diseases with improved therapeutic efficacy and improved dose efficiency |
| WO2017192782A1 (en) | 2016-05-03 | 2017-11-09 | Pneuma Respiratory, Inc. | Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment |
| JP6774508B2 (ja) * | 2016-05-03 | 2020-10-28 | ニューマ・リスパイラトリー・インコーポレイテッド | 流体を肺系に供給するための液滴送達装置、及びその使用方法 |
| US11285274B2 (en) | 2016-05-03 | 2022-03-29 | Pneuma Respiratory, Inc. | Methods for the systemic delivery of therapeutic agents to the pulmonary system using a droplet delivery device |
| ES2760943T3 (es) | 2016-05-23 | 2020-05-18 | Presspart Mfg Ltd | Inhalador de polvo seco |
| CN109496146A (zh) | 2016-05-27 | 2019-03-19 | 优尼瓦健康公司 | 用于使用药剂装置的装置和方法 |
| US10463077B2 (en) | 2016-06-24 | 2019-11-05 | Altria Client Services Llc | Cartridge for e-vaping device with open-microchannels |
| US11110232B2 (en) | 2016-07-19 | 2021-09-07 | Microbase Technology Corp. | Nebulization generating apparatus |
| US20180056018A1 (en) | 2016-08-31 | 2018-03-01 | Cephalon, Inc. | Inhalation Systems, Devices and Methods |
| EP3518921B1 (en) | 2016-09-28 | 2021-08-11 | Novaliq GmbH | Compositions comprising a cannabinoid receptor binding ligand |
| US10758380B2 (en) | 2016-12-30 | 2020-09-01 | Bvw Holding Ag | Stents with improved fixation |
| EP3634552A4 (en) | 2017-05-19 | 2021-03-03 | Pneuma Respiratory, Inc. | DRY POWDER ADMINISTRATION DEVICE AND METHODS OF USE |
| EP4344719B1 (en) | 2017-10-17 | 2025-12-31 | Pneuma Respiratory, Inc. | NASAL MEDICATION ADMINISTRATION DEVICE |
| JP6988365B2 (ja) | 2017-10-20 | 2022-01-05 | オムロンヘルスケア株式会社 | メッシュ式ネブライザおよび交換部材 |
| US11771852B2 (en) | 2017-11-08 | 2023-10-03 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device with small volume ampoule and methods of use |
| CA3083219A1 (en) | 2017-12-08 | 2019-06-13 | Reynaldo Quintana | Fluid delivery alignment system |
| CA3087769A1 (en) | 2018-01-08 | 2019-07-11 | Pneuma Respiratory, Inc. | Treatment of pulmonary cancers using an electronic breath actuated droplet delivery device |
| US20200345588A1 (en) | 2018-01-16 | 2020-11-05 | The Trustees Of Indiana University | Monitor device for real time compliance instructions and user feedback and clinician communication |
| WO2019195239A1 (en) | 2018-04-02 | 2019-10-10 | Pneuma Respiratory, Inc. | Handheld digital nebulizer device and methods of use |
| KR20190122453A (ko) | 2018-04-20 | 2019-10-30 | (의료)길의료재단 | 진세노사이드 Re를 함유하는 호흡기 질환 예방 또는 치료용 약학적 조성물 |
| BR112020019992B1 (pt) | 2018-05-16 | 2023-03-07 | Philip Morris Products S.A | Malha para um conjunto atomizador, conjunto atomizador para um dispositivo gerador de aerossol e dispositivo gerador de aerossol |
| US11517685B2 (en) | 2019-01-18 | 2022-12-06 | Qnovia, Inc. | Electronic device for producing an aerosol for inhalation by a person |
| WO2020072478A1 (en) | 2018-10-01 | 2020-04-09 | Pneuma Respiratory, Inc. | Delivery of low surface tension compositions to the pulmonary system via electronic breath actuated droplet delivery device |
| CA3119536A1 (en) | 2018-11-14 | 2020-05-22 | Loop Laboratories, LLC | Inhalant dispensing system and apparatus |
| GB201821331D0 (en) | 2018-12-31 | 2019-02-13 | 3M Innovative Properties Co | Inhaler detection |
| US20220080137A1 (en) | 2019-01-24 | 2022-03-17 | Pneuma Respiratory, Inc. | Electronic breath actuated droplet delivery systems with dose metering capabilities, inhalation topography methods, and related methods of use |
| CH715947B1 (de) | 2019-03-04 | 2020-11-13 | Sensirion Ag | Überwachungssystem zum Überwachen der Handhabung eines Inhalators, Verfahren zum Betrieb des Systems und Computerprogrammprodukt zur Nutzung in der Umsetzung des Verfahrens |
| EP3965955A4 (en) | 2019-05-09 | 2023-05-10 | Pneuma Respiratory, Inc. | Ultrasonic breath actuated respiratory droplet delivery device and methods of use |
| JP2022538120A (ja) | 2019-06-27 | 2022-08-31 | ニューマ・リスパイラトリー・インコーポレイテッド | 電子呼吸作動式液滴送達デバイスによる呼吸器系への小液滴の送達 |
| EP4054494A1 (en) | 2019-11-05 | 2022-09-14 | Novartis AG | Method for delivering the fluid formulation as a spray or a jet of droplets to a target area on an eye |
| WO2021203038A1 (en) | 2020-04-03 | 2021-10-07 | Pneuma Respiratory, Inc. | Delivery of ginsenosides to the respiratory system via electronic breath actuated droplet delivery device |
| WO2022226407A1 (en) | 2021-04-24 | 2022-10-27 | Pneuma Respiratory, Inc. | Respiratory droplet delivery device with face seal and methods of use |
| US20250228876A1 (en) | 2021-10-13 | 2025-07-17 | Pneuma Respiratory, Inc. | Compositions for delivery of cannabinoids |
-
2018
- 2018-10-04 WO PCT/US2018/054417 patent/WO2019071008A1/en not_active Ceased
- 2018-10-04 EP EP18865088.1A patent/EP3691728B1/en active Active
- 2018-10-04 CN CN202410176111.1A patent/CN118203735A/zh active Pending
- 2018-10-04 US US16/651,715 patent/US11738158B2/en active Active
- 2018-10-04 CA CA3077475A patent/CA3077475A1/en active Pending
- 2018-10-04 JP JP2020519068A patent/JP2020536614A/ja active Pending
- 2018-10-04 CN CN201880073105.6A patent/CN111526914A/zh active Pending
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2023
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|---|---|
| WO2019071008A1 (en) | 2019-04-11 |
| EP3691728A4 (en) | 2021-06-30 |
| CN118203735A (zh) | 2024-06-18 |
| US20200276398A1 (en) | 2020-09-03 |
| EP3691728B1 (en) | 2024-05-22 |
| US11738158B2 (en) | 2023-08-29 |
| EP3691728A1 (en) | 2020-08-12 |
| CN111526914A (zh) | 2020-08-11 |
| US20240181175A1 (en) | 2024-06-06 |
| EP3691728C0 (en) | 2024-05-22 |
| JP2020536614A (ja) | 2020-12-17 |
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