CA3069197A1 - Recombinant uricase enzyme - Google Patents
Recombinant uricase enzyme Download PDFInfo
- Publication number
- CA3069197A1 CA3069197A1 CA3069197A CA3069197A CA3069197A1 CA 3069197 A1 CA3069197 A1 CA 3069197A1 CA 3069197 A CA3069197 A CA 3069197A CA 3069197 A CA3069197 A CA 3069197A CA 3069197 A1 CA3069197 A1 CA 3069197A1
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- Prior art keywords
- uricase
- recombinant mutant
- substituted
- subject
- utilis
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| PCT/US2018/041015 WO2019010369A1 (en) | 2017-07-07 | 2018-07-06 | RECOMBINANT ENZYME URICASE |
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| CN112646790A (zh) * | 2019-10-11 | 2021-04-13 | 上海君实生物医药科技股份有限公司 | 改进的尿酸酶及其用于治疗高尿酸血症的方法 |
| WO2021173808A1 (en) * | 2020-02-25 | 2021-09-02 | Synlogic Operating Company, Inc. | Recombinant bacteria engineered to treat diseases associated with uric acid and methods of use thereof |
| EP4240423A1 (en) | 2020-11-03 | 2023-09-13 | Protalix Ltd. | Modified uricase and uses thereof |
| CN114480320B (zh) * | 2022-02-28 | 2024-01-16 | 复旦大学 | 重组夜猴尿酸酶及其应用 |
| CN118497162B (zh) * | 2024-05-24 | 2025-05-16 | 广东少和生物科技有限公司 | 黑酵母菌尿酸氧化酶及其突变体和应用 |
| CN119876069B (zh) * | 2025-03-12 | 2025-10-21 | 开平牵牛生化制药有限公司 | 具有高活性且免疫原性弱化的人源尿酸氧化酶突变体 |
| CN119876071B (zh) * | 2025-03-12 | 2025-10-21 | 开平牵牛生化制药有限公司 | 低免疫原性的高活性人源尿酸氧化酶突变体 |
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| CA2338665C (en) | 1998-08-06 | 2011-01-18 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
| US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| US6913915B2 (en) | 2001-08-02 | 2005-07-05 | Phoenix Pharmacologics, Inc. | PEG-modified uricase |
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| CN101390969A (zh) * | 2008-11-03 | 2009-03-25 | 中国人民解放军军事医学科学院生物工程研究所 | 降低血液中尿酸浓度的药物 |
| CN101875922B (zh) * | 2009-04-30 | 2012-02-22 | 重庆医科大学 | 一种重组苛求芽孢杆菌胞内尿酸酶及其聚乙二醇修饰与应用 |
| SG176897A1 (en) | 2009-06-25 | 2012-01-30 | Savient Pharmaceuticals Inc | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy |
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| CN102586315A (zh) * | 2012-02-21 | 2012-07-18 | 章泽人 | 一种低尿酸分泌量益生菌及其制备方法 |
| WO2014170916A2 (en) * | 2013-04-17 | 2014-10-23 | Council Of Scientific & Industrial Research | Novel uricase mutants |
| CN104342415A (zh) * | 2014-07-08 | 2015-02-11 | 吉林省金梓源生物科技有限公司 | 一种重组尿酸酶的制备方法 |
| TW201618773A (zh) * | 2014-08-11 | 2016-06-01 | 艾森塔製藥公司 | Ｂｔｋ抑制劑、ｐｉ３ｋ抑制劑、ｊａｋ－２抑制劑、及／或ｃｄｋ４／６抑制劑的治療組合物 |
| CN106554948B (zh) | 2015-09-29 | 2019-06-25 | 上海生物制品研究所有限责任公司 | 突变型尿酸酶、peg修饰的突变型尿酸酶及其应用 |
| SI3426285T1 (sl) | 2016-03-11 | 2025-05-30 | Cartesian Therapeutics, Inc. | Formulacije in odmerki pegilirane urikaze |
| WO2018089808A1 (en) | 2016-11-11 | 2018-05-17 | Horizon Pharma Rheumatology Llc | Combination therapies of prednisone and uricase molecules and uses thereof |
| EP3592389B1 (en) | 2017-03-11 | 2025-05-07 | Cartesian Therapeutics, Inc. | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| CN107308452A (zh) * | 2017-05-29 | 2017-11-03 | 钟术光 | 一种稳定生物活性材料的组合物的制备方法 |
| GB201713732D0 (en) * | 2017-08-25 | 2017-10-11 | Alta Innovations Ltd | Tat expression system |
| CN109223707B (zh) | 2018-09-13 | 2020-12-08 | 中国药科大学 | 一种尿酸酶外用凝胶制剂、其制备方法及用途 |
| CN109846909B (zh) * | 2019-01-31 | 2022-03-22 | 武汉康复得生物科技股份有限公司 | 可在肠道中催化尿酸降解的组合物及其制备方法和应用 |
| KR20250041198A (ko) * | 2019-05-10 | 2025-03-25 | 피이지-바이오 바이오팜 컴퍼니 리미티드 (총칭) | 폴리에틸렌 글리콜로 변형된 요산 산화효소 |
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2023
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| US20200071681A1 (en) | 2020-03-05 |
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| JP2023126877A (ja) | 2023-09-12 |
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