CA3063588A1 - Human antibodies to bet v 1 and methods of use thereof - Google Patents
Human antibodies to bet v 1 and methods of use thereof Download PDFInfo
- Publication number
- CA3063588A1 CA3063588A1 CA3063588A CA3063588A CA3063588A1 CA 3063588 A1 CA3063588 A1 CA 3063588A1 CA 3063588 A CA3063588 A CA 3063588A CA 3063588 A CA3063588 A CA 3063588A CA 3063588 A1 CA3063588 A1 CA 3063588A1
- Authority
- CA
- Canada
- Prior art keywords
- bet
- seq
- amino acid
- antibody
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/16—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762513872P | 2017-06-01 | 2017-06-01 | |
| US62/513,872 | 2017-06-01 | ||
| US201762571696P | 2017-10-12 | 2017-10-12 | |
| US62/571,696 | 2017-10-12 | ||
| US201862662165P | 2018-04-24 | 2018-04-24 | |
| US62/662,165 | 2018-04-24 | ||
| PCT/US2018/035366 WO2018222854A1 (en) | 2017-06-01 | 2018-05-31 | Human antibodies to bet v 1 and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3063588A1 true CA3063588A1 (en) | 2018-12-06 |
Family
ID=62705709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3063588A Pending CA3063588A1 (en) | 2017-06-01 | 2018-05-31 | Human antibodies to bet v 1 and methods of use thereof |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10793624B2 (enExample) |
| EP (1) | EP3630814A1 (enExample) |
| JP (3) | JP6963036B2 (enExample) |
| KR (3) | KR102329175B1 (enExample) |
| CN (1) | CN110997713B (enExample) |
| AU (2) | AU2018275657B2 (enExample) |
| BR (1) | BR112019025150B1 (enExample) |
| CA (1) | CA3063588A1 (enExample) |
| CL (3) | CL2019003508A1 (enExample) |
| CO (1) | CO2019013196A2 (enExample) |
| IL (2) | IL298034B2 (enExample) |
| MX (2) | MX2019014430A (enExample) |
| MY (1) | MY198270A (enExample) |
| NZ (2) | NZ782911A (enExample) |
| PH (1) | PH12019550238A1 (enExample) |
| WO (1) | WO2018222854A1 (enExample) |
| ZA (1) | ZA201907513B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2919934T3 (es) | 2017-05-05 | 2022-07-29 | Regeneron Pharma | Autoinyector y procedimientos de uso relacionados |
| AU2018275657B2 (en) * | 2017-06-01 | 2022-01-06 | Regeneron Pharmaceuticals, Inc. | Human antibodies to Bet v 1 and methods of use thereof |
| EP4175986A1 (en) * | 2020-07-01 | 2023-05-10 | Regeneron Pharmaceuticals, Inc. | Methods of treating allergy using anti-bet v 1 antibodies |
| CN113041271B (zh) * | 2021-04-14 | 2022-12-27 | 浙江养生堂天然药物研究所有限公司 | 具有预防和抗过敏功效的组合物 |
| EP4444348A4 (en) * | 2021-12-08 | 2025-12-03 | Iggenix Inc | COMBINATIONS FOR ALLERGY THERAPY |
| WO2024200854A1 (en) | 2023-03-31 | 2024-10-03 | Alk-Abelló A/S | Allergen binding antibodies suitable for treating tree pollen allergies |
| WO2024251358A1 (en) | 2023-06-07 | 2024-12-12 | Mabylon Ag | Anti-allergen antibodies and uses thereof |
| WO2024259313A1 (en) | 2023-06-16 | 2024-12-19 | Regeneron Pharamceuticals, Inc. | Medical device packaging and related methods |
| US12319747B2 (en) | 2023-07-03 | 2025-06-03 | Medicovestor, Inc. | Methods of using anti-SP17 immunotherapeutics |
| US20250011403A1 (en) * | 2023-07-03 | 2025-01-09 | Medicovestor, Inc. | Nucleic acids, vectors, and cells that encode anti-sp17 antibodies and other sp17 binding proteins |
| AR134008A1 (es) | 2023-10-02 | 2025-11-26 | Regeneron Pharma | Sistema de seguridad de dispositivo de administración de fármaco |
| US12364777B2 (en) | 2023-10-20 | 2025-07-22 | Medicovestor, Inc. | Homodimeric antibodies for use in treating cancers and methods of use |
| US20250255994A1 (en) * | 2023-11-29 | 2025-08-14 | Medicovestor, Inc. | Dimeric immunoconjugates for use in treating cancers and methods of use |
| US12116410B1 (en) | 2023-12-26 | 2024-10-15 | Medicovestor, Inc. | Methods of manufacturing dimeric antibodies |
| US20250263471A1 (en) | 2024-01-30 | 2025-08-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating allergy using anti-bet v 1 antibodies |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5411594A (en) | 1992-10-27 | 1994-05-24 | Biomay Produktions- Und Handelsgesellschaft M.B.H. | Molecule fragments (peptides) of the main allergens contained in the pollen of trees of the (fagales) order |
| JPH08501799A (ja) | 1992-12-21 | 1996-02-27 | タノックス バイオシステムズ インコーポレイテッド | アレルゲン特異的ＩｇＡモノクローナル抗体及びアレルギー治療のための関連物質 |
| EP0619323A1 (en) | 1993-04-09 | 1994-10-12 | Schering-Plough | Human monoclonal antibodies and processes and materials for making such antibodies |
| GB0002386D0 (en) | 2000-02-02 | 2000-03-22 | Novartis Nutrition Ag | Therapeutic composition |
| US6849259B2 (en) | 2000-06-16 | 2005-02-01 | Symphogen A/S | Polyclonal antibody composition for treating allergy |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| EP1740946B1 (en) | 2004-04-20 | 2013-11-06 | Genmab A/S | Human monoclonal antibodies against cd20 |
| ITMI20052517A1 (it) * | 2005-12-29 | 2007-06-30 | Lofarma Spa | Varianbtio ipoallergeniche dell'allergene maggiore bet v 1 di polline di betula verrucosa |
| AT503297B1 (de) * | 2006-05-18 | 2007-09-15 | Biomay Ag | Allergen-spezifische antikörper |
| CA2652976C (en) | 2006-06-02 | 2015-08-11 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human il-6 receptor |
| GB201002559D0 (en) | 2010-02-15 | 2010-03-31 | Circassia Ltd | Birch peptides for vaccine |
| TWI655207B (zh) * | 2013-07-30 | 2019-04-01 | 再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| WO2015027154A2 (en) | 2013-08-23 | 2015-02-26 | Regeneron Pharmaceuticals, Inc. | Diagnostic tests and methods for assessing safety, efficacy or outcome of allergen-specific immunotherapy (sit) |
| AU2018275657B2 (en) * | 2017-06-01 | 2022-01-06 | Regeneron Pharmaceuticals, Inc. | Human antibodies to Bet v 1 and methods of use thereof |
| TWI838389B (zh) | 2018-07-19 | 2024-04-11 | 美商再生元醫藥公司 | 雙特異性抗-BCMAｘ抗-CD3抗體及其用途 |
| EP4175986A1 (en) * | 2020-07-01 | 2023-05-10 | Regeneron Pharmaceuticals, Inc. | Methods of treating allergy using anti-bet v 1 antibodies |
-
2018
- 2018-05-31 AU AU2018275657A patent/AU2018275657B2/en active Active
- 2018-05-31 KR KR1020197036599A patent/KR102329175B1/ko active Active
- 2018-05-31 MX MX2019014430A patent/MX2019014430A/es unknown
- 2018-05-31 CN CN201880049949.7A patent/CN110997713B/zh active Active
- 2018-05-31 US US15/994,294 patent/US10793624B2/en active Active
- 2018-05-31 IL IL298034A patent/IL298034B2/en unknown
- 2018-05-31 CA CA3063588A patent/CA3063588A1/en active Pending
- 2018-05-31 KR KR1020247018848A patent/KR102878718B1/ko active Active
- 2018-05-31 WO PCT/US2018/035366 patent/WO2018222854A1/en not_active Ceased
- 2018-05-31 NZ NZ782911A patent/NZ782911A/en unknown
- 2018-05-31 EP EP18733431.3A patent/EP3630814A1/en active Pending
- 2018-05-31 BR BR112019025150-2A patent/BR112019025150B1/pt active IP Right Grant
- 2018-05-31 MY MYPI2019006625A patent/MY198270A/en unknown
- 2018-05-31 IL IL270894A patent/IL270894B2/en unknown
- 2018-05-31 JP JP2019565912A patent/JP6963036B2/ja active Active
- 2018-05-31 NZ NZ759513A patent/NZ759513A/en unknown
- 2018-05-31 KR KR1020217037411A patent/KR102674000B1/ko active Active
-
2019
- 2019-11-13 ZA ZA2019/07513A patent/ZA201907513B/en unknown
- 2019-11-14 PH PH12019550238A patent/PH12019550238A1/en unknown
- 2019-11-26 CO CONC2019/0013196A patent/CO2019013196A2/es unknown
- 2019-11-29 MX MX2023000390A patent/MX2023000390A/es unknown
- 2019-11-29 CL CL2019003508A patent/CL2019003508A1/es unknown
-
2020
- 2020-08-28 US US17/006,599 patent/US11767358B2/en active Active
-
2021
- 2021-04-27 JP JP2021074862A patent/JP7162097B2/ja active Active
- 2021-10-29 CL CL2021002850A patent/CL2021002850A1/es unknown
- 2021-10-29 CL CL2021002851A patent/CL2021002851A1/es unknown
-
2022
- 2022-01-17 AU AU2022200272A patent/AU2022200272B2/en active Active
- 2022-09-15 JP JP2022146982A patent/JP7458453B2/ja active Active
-
2023
- 2023-08-09 US US18/232,238 patent/US20240083986A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220718 |
|
| EEER | Examination request |
Effective date: 20220718 |
|
| EEER | Examination request |
Effective date: 20220718 |
|
| EEER | Examination request |
Effective date: 20220718 |
|
| EEER | Examination request |
Effective date: 20220718 |