CA3060030A1 - Dementia therapeutic agent combining pyrazoloquinoline derivative and donepezil - Google Patents

Dementia therapeutic agent combining pyrazoloquinoline derivative and donepezil Download PDF

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Publication number
CA3060030A1
CA3060030A1 CA3060030A CA3060030A CA3060030A1 CA 3060030 A1 CA3060030 A1 CA 3060030A1 CA 3060030 A CA3060030 A CA 3060030A CA 3060030 A CA3060030 A CA 3060030A CA 3060030 A1 CA3060030 A1 CA 3060030A1
Authority
CA
Canada
Prior art keywords
acceptable salt
pharmaceutically acceptable
donepezil
disease
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3060030A
Other languages
English (en)
French (fr)
Inventor
Mai Miyamoto
Sadaharu Kotani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Publication of CA3060030A1 publication Critical patent/CA3060030A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3060030A 2017-06-01 2018-05-30 Dementia therapeutic agent combining pyrazoloquinoline derivative and donepezil Pending CA3060030A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762513692P 2017-06-01 2017-06-01
US62/513,692 2017-06-01
PCT/JP2018/020638 WO2018221545A1 (ja) 2017-06-01 2018-05-30 ピラゾロキノリン誘導体とドネペジルの併用による認知症治療剤

Publications (1)

Publication Number Publication Date
CA3060030A1 true CA3060030A1 (en) 2018-12-06

Family

ID=64455958

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3060030A Pending CA3060030A1 (en) 2017-06-01 2018-05-30 Dementia therapeutic agent combining pyrazoloquinoline derivative and donepezil

Country Status (13)

Country Link
US (1) US11833146B2 (https=)
EP (1) EP3632439B1 (https=)
JP (2) JP7079777B2 (https=)
KR (1) KR102627787B1 (https=)
CN (1) CN110603040B (https=)
AU (1) AU2018276565A1 (https=)
BR (1) BR112019023569A2 (https=)
CA (1) CA3060030A1 (https=)
ES (1) ES2980131T3 (https=)
IL (1) IL270395B (https=)
RU (1) RU2019135834A (https=)
SG (2) SG11201909595VA (https=)
WO (1) WO2018221545A1 (https=)

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BR112019023552A2 (pt) 2017-06-01 2020-06-02 Eisai R&D Management Co., Ltd. Agente terapêutico para a demência com corpos de lewy contendo derivado de pirazoloquinolina
KR20200010211A (ko) 2017-06-01 2020-01-30 에자이 알앤드디 매니지먼트 가부시키가이샤 Pde9 저해제를 포함하는 약제학적 조성물
KR102271305B1 (ko) 2020-05-21 2021-06-30 주식회사 아리바이오 치매 예방 및 치료용 조성물
KR102272907B1 (ko) 2020-11-05 2021-07-05 주식회사 아리바이오 치매 예방 및 치료용 조성물
KR102272910B1 (ko) 2021-01-28 2021-07-06 주식회사 아리바이오 당뇨병을 동반한 치매 예방 및 치료용 조성물
KR20220140960A (ko) 2021-04-12 2022-10-19 주식회사 아리바이오 당뇨병을 동반한 치매 예방 및 치료용 조성물
KR102311224B1 (ko) * 2021-04-23 2021-10-13 주식회사 아리바이오 Pde5 억제제와 글루코코르티코이드 수용체 길항제 병용투여를 통한 치매 예방 및 치료용 조성물
KR20220146095A (ko) 2021-04-23 2022-11-01 주식회사 아리바이오 Pde5 억제제와 글루코코르티코이드 수용체 길항제 병용투여를 통한 치매 예방 및 치료용 조성물
WO2023064857A1 (en) 2021-10-14 2023-04-20 Incyte Corporation Quinoline compounds as inhibitors of kras

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BR112019023552A2 (pt) 2017-06-01 2020-06-02 Eisai R&D Management Co., Ltd. Agente terapêutico para a demência com corpos de lewy contendo derivado de pirazoloquinolina
WO2018221550A1 (ja) 2017-06-01 2018-12-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロキノリン誘導体とメマンチンの併用による認知症治療剤
CN108563565B (zh) 2018-04-08 2021-12-17 中国人民解放军海军工程大学 飞行着陆引导系统可靠性定量分析模型建立方法

Also Published As

Publication number Publication date
EP3632439B1 (en) 2024-03-27
ES2980131T3 (es) 2024-09-30
SG11201909595VA (en) 2019-11-28
JP7288999B2 (ja) 2023-06-08
IL270395A (https=) 2020-02-27
IL270395B (en) 2022-08-01
KR20200010224A (ko) 2020-01-30
SG10202113198TA (en) 2021-12-30
US20200129501A1 (en) 2020-04-30
KR102627787B1 (ko) 2024-01-23
JP7079777B2 (ja) 2022-06-02
CN110603040A (zh) 2019-12-20
CN110603040B (zh) 2023-02-28
RU2019135834A (ru) 2021-07-13
EP3632439A1 (en) 2020-04-08
WO2018221545A1 (ja) 2018-12-06
US11833146B2 (en) 2023-12-05
BR112019023569A2 (pt) 2020-06-02
JPWO2018221545A1 (ja) 2020-04-02
AU2018276565A1 (en) 2019-11-07
EP3632439A4 (en) 2021-02-17
RU2019135834A3 (https=) 2021-10-15
JP2022110143A (ja) 2022-07-28

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