KR102627787B1 - 피라졸로퀴놀린 유도체와 도네페질을 병용한 치매 치료제 - Google Patents

피라졸로퀴놀린 유도체와 도네페질을 병용한 치매 치료제 Download PDF

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KR102627787B1
KR102627787B1 KR1020197033197A KR20197033197A KR102627787B1 KR 102627787 B1 KR102627787 B1 KR 102627787B1 KR 1020197033197 A KR1020197033197 A KR 1020197033197A KR 20197033197 A KR20197033197 A KR 20197033197A KR 102627787 B1 KR102627787 B1 KR 102627787B1
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pharmaceutically acceptable
acceptable salt
formula
dimethylpyridin
pyrazolo
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KR20200010224A (ko
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마이 미야모토
사다하루 고타니
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에자이 알앤드디 매니지먼트 가부시키가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020197033197A 2017-06-01 2018-05-30 피라졸로퀴놀린 유도체와 도네페질을 병용한 치매 치료제 Active KR102627787B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762513692P 2017-06-01 2017-06-01
US62/513,692 2017-06-01
PCT/JP2018/020638 WO2018221545A1 (ja) 2017-06-01 2018-05-30 ピラゾロキノリン誘導体とドネペジルの併用による認知症治療剤

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KR20200010224A KR20200010224A (ko) 2020-01-30
KR102627787B1 true KR102627787B1 (ko) 2024-01-23

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US (1) US11833146B2 (https=)
EP (1) EP3632439B1 (https=)
JP (2) JP7079777B2 (https=)
KR (1) KR102627787B1 (https=)
CN (1) CN110603040B (https=)
AU (1) AU2018276565A1 (https=)
BR (1) BR112019023569A2 (https=)
CA (1) CA3060030A1 (https=)
ES (1) ES2980131T3 (https=)
IL (1) IL270395B (https=)
RU (1) RU2019135834A (https=)
SG (2) SG11201909595VA (https=)
WO (1) WO2018221545A1 (https=)

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WO2018221550A1 (ja) 2017-06-01 2018-12-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロキノリン誘導体とメマンチンの併用による認知症治療剤
BR112019023552A2 (pt) 2017-06-01 2020-06-02 Eisai R&D Management Co., Ltd. Agente terapêutico para a demência com corpos de lewy contendo derivado de pirazoloquinolina
KR20200010211A (ko) 2017-06-01 2020-01-30 에자이 알앤드디 매니지먼트 가부시키가이샤 Pde9 저해제를 포함하는 약제학적 조성물
KR102271305B1 (ko) 2020-05-21 2021-06-30 주식회사 아리바이오 치매 예방 및 치료용 조성물
KR102272907B1 (ko) 2020-11-05 2021-07-05 주식회사 아리바이오 치매 예방 및 치료용 조성물
KR102272910B1 (ko) 2021-01-28 2021-07-06 주식회사 아리바이오 당뇨병을 동반한 치매 예방 및 치료용 조성물
KR20220140960A (ko) 2021-04-12 2022-10-19 주식회사 아리바이오 당뇨병을 동반한 치매 예방 및 치료용 조성물
KR102311224B1 (ko) * 2021-04-23 2021-10-13 주식회사 아리바이오 Pde5 억제제와 글루코코르티코이드 수용체 길항제 병용투여를 통한 치매 예방 및 치료용 조성물
KR20220146095A (ko) 2021-04-23 2022-11-01 주식회사 아리바이오 Pde5 억제제와 글루코코르티코이드 수용체 길항제 병용투여를 통한 치매 예방 및 치료용 조성물
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Also Published As

Publication number Publication date
EP3632439B1 (en) 2024-03-27
ES2980131T3 (es) 2024-09-30
SG11201909595VA (en) 2019-11-28
JP7288999B2 (ja) 2023-06-08
IL270395A (https=) 2020-02-27
IL270395B (en) 2022-08-01
KR20200010224A (ko) 2020-01-30
SG10202113198TA (en) 2021-12-30
US20200129501A1 (en) 2020-04-30
JP7079777B2 (ja) 2022-06-02
CN110603040A (zh) 2019-12-20
CN110603040B (zh) 2023-02-28
RU2019135834A (ru) 2021-07-13
EP3632439A1 (en) 2020-04-08
WO2018221545A1 (ja) 2018-12-06
US11833146B2 (en) 2023-12-05
BR112019023569A2 (pt) 2020-06-02
CA3060030A1 (en) 2018-12-06
JPWO2018221545A1 (ja) 2020-04-02
AU2018276565A1 (en) 2019-11-07
EP3632439A4 (en) 2021-02-17
RU2019135834A3 (https=) 2021-10-15
JP2022110143A (ja) 2022-07-28

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