CA3053803A1 - Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof - Google Patents

Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof Download PDF

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Publication number
CA3053803A1
CA3053803A1 CA3053803A CA3053803A CA3053803A1 CA 3053803 A1 CA3053803 A1 CA 3053803A1 CA 3053803 A CA3053803 A CA 3053803A CA 3053803 A CA3053803 A CA 3053803A CA 3053803 A1 CA3053803 A1 CA 3053803A1
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Prior art keywords
seq
mab
variable domain
chain variable
heavy chain
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CA3053803A
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English (en)
French (fr)
Inventor
Liqin Liu
Chia-Ying Kao Lam
Gundo Diedrich
Leslie S. Johnson
Paul A. Moore
Ezio Bonvini
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Macrogenics Inc
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Macrogenics Inc
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    • G11C15/04—Digital stores in which information comprising one or more characteristic parts is written into the store and in which information is read-out by searching for one or more of these characteristic parts, i.e. associative or content-addressed stores using semiconductor elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K—PEPTIDES
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
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  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3053803A 2017-02-24 2018-02-22 Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof Pending CA3053803A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762463353P 2017-02-24 2017-02-24
US62/463,353 2017-02-24
US201762597594P 2017-12-12 2017-12-12
US62/597,594 2017-12-12
PCT/US2018/019188 WO2018156740A1 (en) 2017-02-24 2018-02-22 Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof

Publications (1)

Publication Number Publication Date
CA3053803A1 true CA3053803A1 (en) 2018-08-30

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ID=63252984

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CA3053803A Pending CA3053803A1 (en) 2017-02-24 2018-02-22 Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof

Country Status (15)

Country Link
US (3) US11459394B2 (https=)
EP (2) EP3585431A4 (https=)
JP (1) JP7132232B2 (https=)
KR (1) KR102585848B1 (https=)
CN (1) CN110325209A (https=)
AU (1) AU2018224094B2 (https=)
BR (1) BR112019017628A2 (https=)
CA (1) CA3053803A1 (https=)
IL (1) IL268836B2 (https=)
MA (1) MA47612A (https=)
MX (1) MX2019009967A (https=)
SG (1) SG11201907753TA (https=)
TW (1) TWI788327B (https=)
WO (1) WO2018156740A1 (https=)
ZA (1) ZA201905347B (https=)

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