CA3050133A1 - Tissue-specific wnt signal enhancing molecules and uses thereof - Google Patents

Tissue-specific wnt signal enhancing molecules and uses thereof Download PDF

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Publication number
CA3050133A1
CA3050133A1 CA3050133A CA3050133A CA3050133A1 CA 3050133 A1 CA3050133 A1 CA 3050133A1 CA 3050133 A CA3050133 A CA 3050133A CA 3050133 A CA3050133 A CA 3050133A CA 3050133 A1 CA3050133 A1 CA 3050133A1
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Prior art keywords
tissue
polypeptide
wnt
molecule
domain
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CA3050133A
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English (en)
French (fr)
Inventor
Zhengjian ZHANG
Jennifer Jean BRADY
Aaron Ken Sato
Wen-Chen Yeh
Yang Li
Teppei YAMAGUCHI
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Surrozen Operating Inc
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Surrozen Inc
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Publication of CA3050133A1 publication Critical patent/CA3050133A1/en
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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CA3050133A 2017-01-26 2018-01-26 Tissue-specific wnt signal enhancing molecules and uses thereof Pending CA3050133A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762450804P 2017-01-26 2017-01-26
US62/450,804 2017-01-26
US201762487135P 2017-04-19 2017-04-19
US62/487,135 2017-04-19
PCT/US2018/015595 WO2018140821A1 (en) 2017-01-26 2018-01-26 Tissue-specific wnt signal enhancing molecules and uses thereof

Publications (1)

Publication Number Publication Date
CA3050133A1 true CA3050133A1 (en) 2018-08-02

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Application Number Title Priority Date Filing Date
CA3050133A Pending CA3050133A1 (en) 2017-01-26 2018-01-26 Tissue-specific wnt signal enhancing molecules and uses thereof

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Country Link
US (2) US11958891B2 (cg-RX-API-DMAC7.html)
EP (1) EP3574019A4 (cg-RX-API-DMAC7.html)
JP (3) JP7305543B2 (cg-RX-API-DMAC7.html)
CN (1) CN110234662A (cg-RX-API-DMAC7.html)
AU (1) AU2018211985B2 (cg-RX-API-DMAC7.html)
CA (1) CA3050133A1 (cg-RX-API-DMAC7.html)
WO (1) WO2018140821A1 (cg-RX-API-DMAC7.html)

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CA3050133A1 (en) 2017-01-26 2018-08-02 Surrozen, Inc. Tissue-specific wnt signal enhancing molecules and uses thereof
JP7317016B2 (ja) 2017-12-19 2023-07-28 スロゼン オペレーティング， インコーポレイテッド 抗ｌｒｐ５／６抗体及び使用方法
US12006368B2 (en) 2017-12-19 2024-06-11 Surrozen Operating, Inc. Anti-frizzled antibodies and methods of use
AU2018393073B2 (en) 2017-12-19 2025-09-18 Surrozen Operating, Inc. Wnt surrogate molecules and uses thereof
WO2020014271A1 (en) * 2018-07-09 2020-01-16 Surrozen, Inc. Tissue-specific wnt signal enhancing molecules and uses
CA3125274A1 (en) * 2018-12-27 2020-07-02 H. Lee Moffitt Cancer Center And Research Institute Inc. Bispecific antibody for membrane clearance of target receptors
CA3129155A1 (en) * 2019-02-11 2020-08-20 Surrozen, Inc. Modulation of wnt signalling in ocular disorders
WO2020206005A1 (en) * 2019-04-02 2020-10-08 Surrozen, Inc. Modulation of wnt signaling in auditory disorders
EP3983443A4 (en) * 2019-06-11 2023-06-07 Antlera Therapeutics Inc. MULTIVALENT FZD AND WNT BINDING MOLECULES AND USES THEREOF
WO2020257758A1 (en) 2019-06-21 2020-12-24 Regeneron Pharmaceuticals, Inc. Treatment of decreased bone mineral density with zinc and ring finger 3 (znrf3) inhibitors
KR102192471B1 (ko) * 2019-10-18 2020-12-17 주식회사 인코스팜 탈모 완화 및 모발 성장을 촉진시키는 펩타이드 및 이를 포함하는 화장료 조성물
CA3166963A1 (en) * 2020-01-09 2021-07-15 Kimberly Drenser Neural regeneration with synthetic protein administration
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US20230399418A1 (en) * 2020-11-10 2023-12-14 The Scripps Research Institute Antibodies for opioid treatments
JP2023549854A (ja) * 2020-11-16 2023-11-29 スロゼン オペレーティング， インコーポレイテッド 肝臓特異的Ｗｎｔシグナル増強分子およびその使用
CN112386687B (zh) * 2020-12-09 2021-05-04 爱龄医美国际健康咨询服务(北京)有限公司 一种干细胞外泌体及其在药品和化妆品中的应用
CN113307882B (zh) * 2021-05-12 2022-12-20 东北大学 靶向治疗Rspo过度激活导致的结直肠癌的融合蛋白SZ1及其偶联纳米药物
CN113293214A (zh) * 2021-06-17 2021-08-24 深圳华因康基因科技有限公司 一种检测神经母细胞瘤复发转移基因wnt2扩增的引物探针及其应用
CA3225626A1 (en) * 2021-07-15 2023-01-19 Diogenx Recombinant variants of r-spondin proteins and their use
EP4428238A1 (en) * 2021-11-02 2024-09-11 Rena Therapeutics Inc. Ligand-bound nucleic acid complex
CN116789843B (zh) * 2022-03-16 2024-09-17 伯桢生物科技(杭州)有限公司 Wnt重组蛋白及其应用
CN116836274B (zh) * 2022-03-23 2024-11-22 东莞市朋志生物科技有限公司 抗血清淀粉样蛋白a抗体、检测血清淀粉样蛋白a的试剂和试剂盒
WO2023250291A2 (en) * 2022-06-21 2023-12-28 Surrozen Operating, Inc. Modulation of wnt signalling in corneal disorders
WO2025146152A1 (zh) * 2024-01-04 2025-07-10 上海宝济药业股份有限公司 一种药物组合物及其应用
CN120647751B (zh) * 2025-08-18 2025-12-02 成都迈科康生物科技有限公司 抗人乳头瘤病毒e1蛋白的抗体或其试剂盒和相关应用

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