CA3044112A1 - Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a - Google Patents

Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a Download PDF

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Publication number
CA3044112A1
CA3044112A1 CA3044112A CA3044112A CA3044112A1 CA 3044112 A1 CA3044112 A1 CA 3044112A1 CA 3044112 A CA3044112 A CA 3044112A CA 3044112 A CA3044112 A CA 3044112A CA 3044112 A1 CA3044112 A1 CA 3044112A1
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CA
Canada
Prior art keywords
seq
ahd
prd
amino acid
pspa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3044112A
Other languages
English (en)
French (fr)
Inventor
David E. Briles
Hiroshi Kiyono
Robert Kneller
Reshmi MUKERJI
Kristopher GENSCHMER
Yoshikazu Yuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tokyo NUC
UAB Research Foundation
Original Assignee
University of Tokyo NUC
UAB Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tokyo NUC, UAB Research Foundation filed Critical University of Tokyo NUC
Publication of CA3044112A1 publication Critical patent/CA3044112A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3044112A 2016-12-03 2017-12-01 Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a Pending CA3044112A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662429782P 2016-12-03 2016-12-03
US62/429,782 2016-12-03
PCT/US2017/064347 WO2018102774A2 (en) 2016-12-03 2017-12-01 Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a

Publications (1)

Publication Number Publication Date
CA3044112A1 true CA3044112A1 (en) 2018-06-07

Family

ID=61028164

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3044112A Pending CA3044112A1 (en) 2016-12-03 2017-12-01 Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a

Country Status (8)

Country Link
US (1) US11806392B2 (OSRAM)
EP (1) EP3548076A2 (OSRAM)
JP (1) JP7246644B2 (OSRAM)
KR (1) KR102608642B1 (OSRAM)
CN (1) CN110381992A (OSRAM)
AU (2) AU2017366726B2 (OSRAM)
CA (1) CA3044112A1 (OSRAM)
WO (1) WO2018102774A2 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11806392B2 (en) 2016-12-03 2023-11-07 The Uab Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113631186B (zh) * 2019-03-29 2024-10-29 国立大学法人东京大学 肺炎球菌表面蛋白
CN110452374B (zh) 2019-08-30 2021-09-28 苏州大学 具有高效基因递送能力的三维球形α螺旋阳离子聚多肽及其制备方法与应用
AU2022405521A1 (en) 2021-12-08 2024-05-09 Immunitybio, Inc. Neoepitope vaccine delivery vehicle and methods of making the same
WO2025012364A1 (en) 2023-07-12 2025-01-16 Virometix Ag Compositions of pneumococcal antigens

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
DK0571538T5 (da) 1991-02-15 2002-03-04 Uab Research Foundation Strukturgen for pneumokokprotein
US5980909A (en) 1991-02-15 1999-11-09 Uab Research Foundation Epitopic regions of pneumococcal surface protein A
US6592876B1 (en) * 1993-04-20 2003-07-15 Uab Research Foundation Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products
US5476929A (en) * 1991-02-15 1995-12-19 Uab Research Foundation Structural gene of pneumococcal protein
US5955089A (en) 1993-04-20 1999-09-21 Uab Research Foundation Strain selection of pneumococcal surface proteins
CA2116261A1 (en) * 1993-04-20 1994-10-21 David E. Briles Epitopic regions of pneumococcal surface protein a
ATE536370T1 (de) 2006-02-02 2011-12-15 Univ Alabama Res Found Nicht gespulte schutzregionen der pneumokokken- oberflächenproteine pspa und pspc
JP5344558B2 (ja) 2008-10-31 2013-11-20 国立大学法人 東京医科歯科大学 カチオン性ナノゲルを用いる粘膜ワクチン
SG11201402610QA (en) 2011-12-09 2014-10-30 Metavention Inc Therapeutic neuromodulation of the hepatic system
RU2510281C2 (ru) 2012-06-22 2014-03-27 Общество с ограниченной ответственностью "Эпитоп" (ООО "Эпитоп") ВАКЦИНА ПРОТИВ ПНЕВМОНИИ, ВЫЗЫВАЕМОЙ Streptococcus pneumoniae, НА ОСНОВЕ ГИБРИДНОГО БЕЛКА
US9938326B2 (en) 2012-09-19 2018-04-10 Osaka University Pneumococcal vaccine containing pneumococcal surface protein A
KR20160088323A (ko) * 2013-12-03 2016-07-25 비로메틱스 아게 S. 뉴모니에(S. pneumoniae)에 대항하는 보호성 프롤린-풍부한 펩티드
WO2015089587A1 (en) 2013-12-18 2015-06-25 Commonwealth Scientific And Industrial Research Organisation Lipid comprising long chain polyunsaturated fatty acids
CN103834667B (zh) 2013-12-31 2016-08-17 李越希 化学合成的肺炎链球菌PspA蛋白胞外区基因片段及其表达、应用
JP6310720B2 (ja) 2014-02-17 2018-04-11 知的財産戦略ネットワーク株式会社 肺炎球菌経鼻ワクチン
CN104888224B (zh) * 2015-03-25 2019-02-01 中山大学 一种两亲性多糖衍生物/泊洛沙姆温敏型原位水凝胶及其制备方法
CN104844712B (zh) 2015-04-03 2019-06-28 长春百克生物科技股份公司 肺炎链球菌蛋白抗原及其制备方法和应用
EP3548076A2 (en) 2016-12-03 2019-10-09 The UAB Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11806392B2 (en) 2016-12-03 2023-11-07 The Uab Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A

Also Published As

Publication number Publication date
KR102608642B1 (ko) 2023-11-30
EP3548076A2 (en) 2019-10-09
AU2017366726B2 (en) 2021-12-09
JP7246644B2 (ja) 2023-03-28
WO2018102774A3 (en) 2018-07-12
WO2018102774A2 (en) 2018-06-07
KR20190110090A (ko) 2019-09-27
RU2019118969A3 (OSRAM) 2021-01-11
CN110381992A (zh) 2019-10-25
AU2021269320A1 (en) 2021-12-09
US20190351043A1 (en) 2019-11-21
WO2018102774A8 (en) 2019-05-31
US11806392B2 (en) 2023-11-07
RU2019118969A (ru) 2021-01-11
AU2017366726A1 (en) 2019-05-30
JP2020502075A (ja) 2020-01-23

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