CA3021358A1 - Bifunctional molecules for degradation of egfr and methods of use - Google Patents
Bifunctional molecules for degradation of egfr and methods of use Download PDFInfo
- Publication number
- CA3021358A1 CA3021358A1 CA3021358A CA3021358A CA3021358A1 CA 3021358 A1 CA3021358 A1 CA 3021358A1 CA 3021358 A CA3021358 A CA 3021358A CA 3021358 A CA3021358 A CA 3021358A CA 3021358 A1 CA3021358 A1 CA 3021358A1
- Authority
- CA
- Canada
- Prior art keywords
- cancer
- formula
- egfr
- bifunctional compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(*)=*(C)N*C=* Chemical compound CC(*)=*(C)N*C=* 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662326574P | 2016-04-22 | 2016-04-22 | |
| US62/326,574 | 2016-04-22 | ||
| PCT/US2017/028950 WO2017185036A1 (en) | 2016-04-22 | 2017-04-21 | Bifunctional molecules for degradation of egfr and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3021358A1 true CA3021358A1 (en) | 2017-10-26 |
Family
ID=60116448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3021358A Pending CA3021358A1 (en) | 2016-04-22 | 2017-04-21 | Bifunctional molecules for degradation of egfr and methods of use |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10450310B2 (enExample) |
| EP (2) | EP3892272B1 (enExample) |
| JP (1) | JP6968823B2 (enExample) |
| CN (1) | CN109475528B (enExample) |
| AU (1) | AU2017254713C1 (enExample) |
| CA (1) | CA3021358A1 (enExample) |
| WO (1) | WO2017185036A1 (enExample) |
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| AU2017250076B2 (en) | 2016-04-12 | 2021-07-22 | The Regents Of The University Of Michigan | Bet protein degraders |
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2017
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| US10450310B2 (en) | 2019-10-22 |
| JP2019519476A (ja) | 2019-07-11 |
| CN109475528A (zh) | 2019-03-15 |
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| EP3892272A1 (en) | 2021-10-13 |
| US11161842B2 (en) | 2021-11-02 |
| AU2017254713A1 (en) | 2018-10-18 |
| US20220017510A1 (en) | 2022-01-20 |
| EP3445357A1 (en) | 2019-02-27 |
| AU2017254713B2 (en) | 2020-11-19 |
| EP3892272B1 (en) | 2024-07-24 |
| CN109475528B (zh) | 2022-01-11 |
| AU2017254713C1 (en) | 2021-04-29 |
| EP3445357B1 (en) | 2021-05-26 |
| EP3445357A4 (en) | 2019-11-06 |
| JP6968823B2 (ja) | 2021-11-17 |
| US20190106417A1 (en) | 2019-04-11 |
| US20200102298A1 (en) | 2020-04-02 |
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