CA3011900A1 - Bcma antibodies and use of same to treat cancer and immunological disorders - Google Patents

Bcma antibodies and use of same to treat cancer and immunological disorders Download PDF

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Publication number
CA3011900A1
CA3011900A1 CA3011900A CA3011900A CA3011900A1 CA 3011900 A1 CA3011900 A1 CA 3011900A1 CA 3011900 A CA3011900 A CA 3011900A CA 3011900 A CA3011900 A CA 3011900A CA 3011900 A1 CA3011900 A1 CA 3011900A1
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CA
Canada
Prior art keywords
antibody
seq
chain variable
heavy chain
variable region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3011900A
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English (en)
French (fr)
Inventor
Django Sussman
Maureen Ryan
Lori WESTENDORF
Michael Feldhaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seagen Inc
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of CA3011900A1 publication Critical patent/CA3011900A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • C07K—PEPTIDES
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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CA3011900A 2016-02-17 2017-02-16 Bcma antibodies and use of same to treat cancer and immunological disorders Pending CA3011900A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662296594P 2016-02-17 2016-02-17
US62/296,594 2016-02-17
US201662396084P 2016-09-16 2016-09-16
US62/396,084 2016-09-16
PCT/US2017/018177 WO2017143069A1 (en) 2016-02-17 2017-02-16 Bcma antibodies and use of same to treat cancer and immunological disorders

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CA3011900A1 true CA3011900A1 (en) 2017-08-24

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CA3011900A Pending CA3011900A1 (en) 2016-02-17 2017-02-16 Bcma antibodies and use of same to treat cancer and immunological disorders

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US (6) US20170233484A1 (enExample)
EP (1) EP3416687A4 (enExample)
JP (4) JP7152309B2 (enExample)
KR (1) KR102816905B1 (enExample)
CN (2) CN108778329B (enExample)
AU (2) AU2017219747B2 (enExample)
BR (1) BR112018016697A2 (enExample)
CA (1) CA3011900A1 (enExample)
HK (1) HK1259075A1 (enExample)
IL (2) IL260732B2 (enExample)
MA (1) MA44254A (enExample)
MX (2) MX2018009700A (enExample)
SG (2) SG10202007836WA (enExample)
WO (1) WO2017143069A1 (enExample)

Families Citing this family (47)

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Publication number Priority date Publication date Assignee Title
MA44254A (fr) 2016-02-17 2018-12-26 Seattle Genetics Inc Anticorps bcma et leur utilisation pour traiter le cancer et les troubles immunologiques
US11166985B2 (en) 2017-05-12 2021-11-09 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
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