CA3007058C - Cytarabine conjugates for cancer therapy - Google Patents
Cytarabine conjugates for cancer therapy Download PDFInfo
- Publication number
- CA3007058C CA3007058C CA3007058A CA3007058A CA3007058C CA 3007058 C CA3007058 C CA 3007058C CA 3007058 A CA3007058 A CA 3007058A CA 3007058 A CA3007058 A CA 3007058A CA 3007058 C CA3007058 C CA 3007058C
- Authority
- CA
- Canada
- Prior art keywords
- subject
- acid
- compound
- cytarabine
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562262428P | 2015-12-03 | 2015-12-03 | |
| US62/262,428 | 2015-12-03 | ||
| PCT/IL2016/050077 WO2017093993A1 (en) | 2015-12-03 | 2016-01-25 | Cytarabine conjugates for cancer therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3007058A1 CA3007058A1 (en) | 2017-06-08 |
| CA3007058C true CA3007058C (en) | 2023-10-17 |
Family
ID=58796462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3007058A Active CA3007058C (en) | 2015-12-03 | 2016-01-25 | Cytarabine conjugates for cancer therapy |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11058701B2 (enExample) |
| EP (1) | EP3383407B1 (enExample) |
| JP (3) | JP7149183B2 (enExample) |
| CN (1) | CN108289905A (enExample) |
| AU (2) | AU2016362830B2 (enExample) |
| BR (1) | BR112018011177A2 (enExample) |
| CA (1) | CA3007058C (enExample) |
| IL (2) | IL259631B (enExample) |
| RU (1) | RU2708672C1 (enExample) |
| WO (1) | WO2017093993A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016362239B2 (en) | 2015-12-03 | 2021-03-25 | BioCytara Ltd. | Salts of conjugates for cancer therapy |
| US12071450B2 (en) | 2015-12-03 | 2024-08-27 | Biosight Ltd. | Salts of conjugates for cancer therapy |
| US12064445B2 (en) | 2015-12-03 | 2024-08-20 | Biosight Ltd. | Cytarabine conjugates for cancer therapy |
| CA3069558A1 (en) * | 2017-07-09 | 2019-01-17 | Biosight Ltd. | Combination cancer therapy |
| CN110590862A (zh) * | 2019-11-01 | 2019-12-20 | 南京师范大学 | 阿糖胞苷4-n位氨基酸衍生物及其制备方法与应用 |
| BR112022015429A2 (pt) * | 2020-02-04 | 2022-09-27 | Biosight Ltd | Composições farmacêuticas de aspacitarabina e usos das mesmas |
| US20230158055A1 (en) * | 2020-04-23 | 2023-05-25 | Biosight Ltd. | Methods and regimens for the treatment of hematological cancer |
| CN116234584A (zh) * | 2020-09-21 | 2023-06-06 | 拜欧赛特有限公司 | 天冬阿糖胞苷的结晶形式 |
| CN112409431B (zh) * | 2020-12-07 | 2023-04-21 | 武汉伯瑞恒医药科技有限公司 | 阿糖胞苷结构类似物及其制备方法和用途 |
| KR20240113533A (ko) * | 2021-11-21 | 2024-07-22 | 바이오사이트 리미티드 | 암 치료를 위한 시타라빈-아미노산 기반 전구약물 |
| WO2023175622A1 (en) * | 2022-03-17 | 2023-09-21 | Biosight Ltd. | Crystalline forms of aspacytarabine |
| WO2023228177A1 (en) * | 2022-05-22 | 2023-11-30 | Biosight Ltd. | Compositions comprising aspacytarabine and additional compounds, and use thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2949451A (en) | 1959-04-21 | 1960-08-16 | Hoffmann La Roche | Preparation of thymidine and deoxyfluorouridine, and intermediates therefor |
| US3041335A (en) | 1959-04-21 | 1962-06-26 | Hoffmann La Roche | Mercury salts of nitrogen heterocyclics and preparation thereof |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4296105A (en) | 1978-08-03 | 1981-10-20 | Institut International De Pathologie Cellulaire Et Moleculaire | Derivatives of doxorubicine, their preparation and use |
| US4348522A (en) | 1980-01-23 | 1982-09-07 | Starks Associates, Inc. | N-(phosphonacetyl)-L-aspartic acid salts with piperazine, cyclohexylamine and calcium |
| EP0329184A3 (en) | 1988-02-19 | 1990-05-23 | Neorx Corporation | Antimers and antimeric conjugation |
| FI105556B (fi) | 1991-09-30 | 2000-09-15 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta |
| US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| JPH09510696A (ja) * | 1994-01-11 | 1997-10-28 | ターゲテック インコーポレイテッド | 肝細胞を標的とする薬物結合体 |
| WO1996005863A1 (fr) | 1994-08-19 | 1996-02-29 | La Region Wallonne | Composes, composition pharmaceutique et dispositif de diagnostic les comprenant et leur utilisation |
| JPH0859688A (ja) | 1994-08-25 | 1996-03-05 | Mitsui Toatsu Chem Inc | ５’−チオノエステル置換トリフルオロチミジン誘導体およびそれを有効成分とする制癌剤 |
| US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| IL126318A (en) | 1996-03-29 | 2004-09-27 | Emisphere Tech Inc | Compounds and compositions for delivering active agents and some novel carrier compounds |
| US6258774B1 (en) | 1998-03-19 | 2001-07-10 | University Of Medicine And Dentistry Of New Jersey | Carrier for in vivo delivery of a therapeutic agent |
| AU773420B2 (en) | 1998-12-11 | 2004-05-27 | Medarex, Inc. | Prodrug compounds and process for preparation thereof |
| BR0315795A (pt) | 2002-10-31 | 2005-09-13 | Metabasis Therapeutics Inc | Pró-medicamentos de monofosfato de citarabina |
| WO2005072061A2 (en) | 2004-02-02 | 2005-08-11 | Biosight Ltd. | Conjugates for cancer therapy and diagnosis |
| KR101442288B1 (ko) | 2006-12-13 | 2014-09-19 | 지보당 네덜란드 서비시즈 비.브이. | 카복실산과 퓨린, 피리미딘, 뉴클레오사이드 또는 뉴클레오타이드의 향미 조절 유도체 |
| CN101812105A (zh) | 2009-02-25 | 2010-08-25 | 沈阳药科大学 | 阿糖胞苷5’-o-氨基酸酯和其盐类及其制备方法 |
| JP5873656B2 (ja) * | 2011-06-13 | 2016-03-01 | 株式会社Ihi | 金属サレン錯体化合物、局所麻酔薬剤及び抗悪性腫瘍薬剤 |
| WO2013058294A1 (ja) | 2011-10-18 | 2013-04-25 | 味の素株式会社 | 膵臓癌及び／又は胆道癌治療薬 |
| AU2013365649A1 (en) | 2012-12-18 | 2015-07-30 | Godavari Biorefineries Limited | Agents for eliminating tumour-initiating cells |
| WO2015178265A1 (ja) | 2014-05-23 | 2015-11-26 | 日本化薬株式会社 | 新規なグルタミン酸誘導体およびその用途 |
-
2016
- 2016-01-25 US US15/780,732 patent/US11058701B2/en active Active - Reinstated
- 2016-01-25 RU RU2018119319A patent/RU2708672C1/ru active
- 2016-01-25 BR BR112018011177A patent/BR112018011177A2/pt not_active Application Discontinuation
- 2016-01-25 CN CN201680070972.5A patent/CN108289905A/zh active Pending
- 2016-01-25 CA CA3007058A patent/CA3007058C/en active Active
- 2016-01-25 AU AU2016362830A patent/AU2016362830B2/en not_active Ceased
- 2016-01-25 JP JP2018527797A patent/JP7149183B2/ja active Active
- 2016-01-25 EP EP16870114.2A patent/EP3383407B1/en active Active
- 2016-01-25 WO PCT/IL2016/050077 patent/WO2017093993A1/en not_active Ceased
-
2018
- 2018-05-27 IL IL259631A patent/IL259631B/en unknown
-
2020
- 2020-07-17 JP JP2020122708A patent/JP2020183419A/ja active Pending
-
2021
- 2021-10-27 IL IL287644A patent/IL287644A/en unknown
-
2022
- 2022-05-10 JP JP2022077787A patent/JP7417658B2/ja active Active
- 2022-06-22 AU AU2022204373A patent/AU2022204373B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017093993A1 (en) | 2017-06-08 |
| AU2022204373B2 (en) | 2024-01-25 |
| EP3383407A1 (en) | 2018-10-10 |
| AU2016362830B2 (en) | 2022-07-14 |
| JP7417658B2 (ja) | 2024-01-18 |
| EP3383407B1 (en) | 2023-12-06 |
| AU2022204373A1 (en) | 2022-07-28 |
| US20180369265A1 (en) | 2018-12-27 |
| CN108289905A (zh) | 2018-07-17 |
| JP7149183B2 (ja) | 2022-10-06 |
| BR112018011177A2 (pt) | 2018-11-21 |
| CA3007058A1 (en) | 2017-06-08 |
| RU2708672C1 (ru) | 2019-12-11 |
| AU2016362830A1 (en) | 2018-07-12 |
| US11058701B2 (en) | 2021-07-13 |
| IL287644A (en) | 2021-12-01 |
| JP2020183419A (ja) | 2020-11-12 |
| JP2018535989A (ja) | 2018-12-06 |
| IL259631A (en) | 2018-07-31 |
| IL259631B (en) | 2021-10-31 |
| EP3383407A4 (en) | 2019-07-17 |
| JP2022097619A (ja) | 2022-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20210114 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20250929 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 9TH ANNIV.) - STANDARD Year of fee payment: 9 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20251117 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20251117 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 10TH ANNIV.) - STANDARD Year of fee payment: 10 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20260120 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20260120 |