AU2016362830B2 - Cytarabine conjugates for cancer therapy - Google Patents

Cytarabine conjugates for cancer therapy Download PDF

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Publication number
AU2016362830B2
AU2016362830B2 AU2016362830A AU2016362830A AU2016362830B2 AU 2016362830 B2 AU2016362830 B2 AU 2016362830B2 AU 2016362830 A AU2016362830 A AU 2016362830A AU 2016362830 A AU2016362830 A AU 2016362830A AU 2016362830 B2 AU2016362830 B2 AU 2016362830B2
Authority
AU
Australia
Prior art keywords
acid
astarabine
subject
cytarabine
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2016362830A
Other languages
English (en)
Other versions
AU2016362830A1 (en
Inventor
Ruth BEN YAKAR
Stela Gengrinovitch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocytara Ltd
Original Assignee
Biosight Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosight Ltd filed Critical Biosight Ltd
Publication of AU2016362830A1 publication Critical patent/AU2016362830A1/en
Priority to AU2022204373A priority Critical patent/AU2022204373B2/en
Application granted granted Critical
Publication of AU2016362830B2 publication Critical patent/AU2016362830B2/en
Assigned to BioCytara Ltd. reassignment BioCytara Ltd. Request for Assignment Assignors: BIOSIGHT LTD.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
AU2016362830A 2015-12-03 2016-01-25 Cytarabine conjugates for cancer therapy Ceased AU2016362830B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022204373A AU2022204373B2 (en) 2015-12-03 2022-06-22 Cytarabine conjugates for cancer therapy

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562262428P 2015-12-03 2015-12-03
US62/262,428 2015-12-03
PCT/IL2016/050077 WO2017093993A1 (en) 2015-12-03 2016-01-25 Cytarabine conjugates for cancer therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022204373A Division AU2022204373B2 (en) 2015-12-03 2022-06-22 Cytarabine conjugates for cancer therapy

Publications (2)

Publication Number Publication Date
AU2016362830A1 AU2016362830A1 (en) 2018-07-12
AU2016362830B2 true AU2016362830B2 (en) 2022-07-14

Family

ID=58796462

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016362830A Ceased AU2016362830B2 (en) 2015-12-03 2016-01-25 Cytarabine conjugates for cancer therapy
AU2022204373A Ceased AU2022204373B2 (en) 2015-12-03 2022-06-22 Cytarabine conjugates for cancer therapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022204373A Ceased AU2022204373B2 (en) 2015-12-03 2022-06-22 Cytarabine conjugates for cancer therapy

Country Status (10)

Country Link
US (1) US11058701B2 (enExample)
EP (1) EP3383407B1 (enExample)
JP (3) JP7149183B2 (enExample)
CN (1) CN108289905A (enExample)
AU (2) AU2016362830B2 (enExample)
BR (1) BR112018011177A2 (enExample)
CA (1) CA3007058C (enExample)
IL (2) IL259631B (enExample)
RU (1) RU2708672C1 (enExample)
WO (1) WO2017093993A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12064445B2 (en) 2015-12-03 2024-08-20 Biosight Ltd. Cytarabine conjugates for cancer therapy
CN108431017B (zh) 2015-12-03 2021-12-21 拜欧赛特有限公司 用于癌症疗法的缀合物的盐
US12071450B2 (en) 2015-12-03 2024-08-27 Biosight Ltd. Salts of conjugates for cancer therapy
BR112020000492A2 (pt) * 2017-07-09 2020-07-14 Biosight Ltd. terapia de câncer de combinação
CN110590862A (zh) * 2019-11-01 2019-12-20 南京师范大学 阿糖胞苷4-n位氨基酸衍生物及其制备方法与应用
CN115052607A (zh) * 2020-02-04 2022-09-13 拜欧赛特有限公司 天冬阿糖胞苷药物组合物和其用途
CN115461058A (zh) * 2020-04-23 2022-12-09 拜欧赛特有限公司 用于治疗血液癌的方法和方案
JP2023541469A (ja) * 2020-09-21 2023-10-02 バイオサイト リミテッド アスパシタラビンの結晶形態
CN112409431B (zh) * 2020-12-07 2023-04-21 武汉伯瑞恒医药科技有限公司 阿糖胞苷结构类似物及其制备方法和用途
CN118434752A (zh) * 2021-11-21 2024-08-02 拜欧赛特有限公司 用于治疗癌症的基于阿糖胞苷-氨基酸的前药
WO2023175622A1 (en) * 2022-03-17 2023-09-21 Biosight Ltd. Crystalline forms of aspacytarabine
WO2023228177A1 (en) * 2022-05-22 2023-11-30 Biosight Ltd. Compositions comprising aspacytarabine and additional compounds, and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110275590A1 (en) * 2004-02-02 2011-11-10 BioSight Ltd., Conjugates for cancer therapy and diagnosis

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US3041335A (en) 1959-04-21 1962-06-26 Hoffmann La Roche Mercury salts of nitrogen heterocyclics and preparation thereof
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4296105A (en) 1978-08-03 1981-10-20 Institut International De Pathologie Cellulaire Et Moleculaire Derivatives of doxorubicine, their preparation and use
US4348522A (en) 1980-01-23 1982-09-07 Starks Associates, Inc. N-(phosphonacetyl)-L-aspartic acid salts with piperazine, cyclohexylamine and calcium
EP0329184A3 (en) 1988-02-19 1990-05-23 Neorx Corporation Antimers and antimeric conjugation
FI105556B (fi) 1991-09-30 2000-09-15 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
CA2180348A1 (en) * 1994-01-11 1995-07-13 Robert Plourde, Jr. Hepatocyte-targeted drug conjugates
ES2297832T3 (es) 1994-08-19 2008-05-01 La Region Wallonne Conjugados que comprenden un agente antitumoral y su utilizacion.
JPH0859688A (ja) 1994-08-25 1996-03-05 Mitsui Toatsu Chem Inc ５’−チオノエステル置換トリフルオロチミジン誘導体およびそれを有効成分とする制癌剤
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
AU2595697A (en) 1996-03-29 1997-10-22 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6258774B1 (en) 1998-03-19 2001-07-10 University Of Medicine And Dentistry Of New Jersey Carrier for in vivo delivery of a therapeutic agent
NZ512171A (en) 1998-12-11 2004-07-30 Medarex Inc Prodrug compound comprising a therapeutic agent, an oligopeptide with a non-genetically encoded amino acid, a stabilizing group and optionally a linker group
AU2003286816B2 (en) 2002-10-31 2010-08-19 Metabasis Therapeutics, Inc. Novel cytarabine monophosphate prodrugs
EP2099316B1 (en) 2006-12-13 2017-06-21 Givaudan S.A. Flavour modulating derivative of a carboxylic acid and a purine, pyrimidine, nucleoside or nucleotide
CN101812105A (zh) 2009-02-25 2010-08-25 沈阳药科大学 阿糖胞苷5’-o-氨基酸酯和其盐类及其制备方法
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US20110275590A1 (en) * 2004-02-02 2011-11-10 BioSight Ltd., Conjugates for cancer therapy and diagnosis

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RENIS, H. E ., "Antiviral Activity of Cytarabine in Herpesvirus-Infected Rats.", Antimicrobial agents and chemotherapy, vol. 4, no. 4, (1973), pages 439 - 444 *

Also Published As

Publication number Publication date
JP2022097619A (ja) 2022-06-30
IL287644A (en) 2021-12-01
US20180369265A1 (en) 2018-12-27
CN108289905A (zh) 2018-07-17
JP2018535989A (ja) 2018-12-06
US11058701B2 (en) 2021-07-13
CA3007058A1 (en) 2017-06-08
JP2020183419A (ja) 2020-11-12
AU2022204373B2 (en) 2024-01-25
JP7417658B2 (ja) 2024-01-18
EP3383407A4 (en) 2019-07-17
JP7149183B2 (ja) 2022-10-06
CA3007058C (en) 2023-10-17
AU2022204373A1 (en) 2022-07-28
IL259631B (en) 2021-10-31
RU2708672C1 (ru) 2019-12-11
EP3383407B1 (en) 2023-12-06
EP3383407A1 (en) 2018-10-10
BR112018011177A2 (pt) 2018-11-21
WO2017093993A1 (en) 2017-06-08
IL259631A (en) 2018-07-31
AU2016362830A1 (en) 2018-07-12

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired
PC Assignment registered

Owner name: BIOCYTARA LTD.

Free format text: FORMER OWNER(S): BIOSIGHT LTD.