CA3004331A1 - Formulations of l-ornithine phenylacetate - Google Patents
Formulations of l-ornithine phenylacetate Download PDFInfo
- Publication number
- CA3004331A1 CA3004331A1 CA3004331A CA3004331A CA3004331A1 CA 3004331 A1 CA3004331 A1 CA 3004331A1 CA 3004331 A CA3004331 A CA 3004331A CA 3004331 A CA3004331 A CA 3004331A CA 3004331 A1 CA3004331 A1 CA 3004331A1
- Authority
- CA
- Canada
- Prior art keywords
- phenylacetylglutamine
- plasma
- pharmaceutical formulation
- phenylacetate
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- LRSYFEZBIMVWRY-VWMHFEHESA-N (2s)-2,5-diaminopentanoic acid;2-phenylacetic acid Chemical compound NCCC[C@H](N)C(O)=O.OC(=O)CC1=CC=CC=C1 LRSYFEZBIMVWRY-VWMHFEHESA-N 0.000 title claims abstract description 71
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- 231100000836 acute liver failure Toxicity 0.000 claims abstract description 5
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 206
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims description 88
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562255300P | 2015-11-13 | 2015-11-13 | |
| US62/255,300 | 2015-11-13 | ||
| US201662276754P | 2016-01-08 | 2016-01-08 | |
| US62/276,754 | 2016-01-08 | ||
| US15/133,087 US20160338982A1 (en) | 2015-04-20 | 2016-04-19 | Formulations of l-ornithine phenylacetate |
| US15/133,087 | 2016-04-19 | ||
| PCT/US2016/061678 WO2017083758A1 (en) | 2015-11-13 | 2016-11-11 | Formulation of l-ornithine phenylacetate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3004331A1 true CA3004331A1 (en) | 2017-05-18 |
Family
ID=58695607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3004331A Abandoned CA3004331A1 (en) | 2015-11-13 | 2016-11-11 | Formulations of l-ornithine phenylacetate |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP3373923A4 (ko) |
| JP (2) | JP7294807B2 (ko) |
| KR (1) | KR20180086431A (ko) |
| CN (2) | CN113768863A (ko) |
| AU (2) | AU2016353350B2 (ko) |
| BR (1) | BR112018009349A8 (ko) |
| CA (1) | CA3004331A1 (ko) |
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| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| EP3668499A1 (en) | 2017-08-14 | 2020-06-24 | Axcella Health Inc. | Amino acid compositions for the treatment of liver disease |
| CN112839643A (zh) | 2018-06-20 | 2021-05-25 | 胺细拉健康公司 | 用于治疗肌肉中脂肪浸润的组合物及方法 |
| CN114786662A (zh) * | 2019-10-16 | 2022-07-22 | 欧塞拉治疗有限公司 | 鸟氨酸苯乙酸盐用于治疗高氨血症的剂量和用途 |
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| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| GB0426141D0 (en) * | 2004-11-26 | 2004-12-29 | Ucl Biomedica Plc | Treatment |
| SI1824563T1 (sl) | 2004-11-26 | 2010-07-30 | Ucl Business Plc | Sestavki, ki obsegajo ornitin in fenilacetat ali fenilbutirat, za zdravljenje hepatične encefalopatije |
| DE102007009243A1 (de) * | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets |
| AU2015221466B2 (en) | 2009-04-03 | 2017-02-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| SG10202010988WA (en) * | 2009-04-03 | 2020-12-30 | Ocera Therapeutics Inc | L-ornithine phenyl acetate and methods of making thereof |
| NZ615091A (en) * | 2009-06-08 | 2015-03-27 | Ucl Business Plc | Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate |
| AU2014250643B2 (en) * | 2009-06-08 | 2016-07-14 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| US8946473B2 (en) * | 2010-10-06 | 2015-02-03 | Ocera Therapeutics, Inc. | Methods of making L-ornithine phenyl acetate |
| CN102993037B (zh) * | 2012-11-20 | 2015-03-04 | 南京工业大学 | 一种l-鸟氨酸苯乙酸盐的制备方法 |
| CN103705490B (zh) * | 2013-10-31 | 2016-08-17 | 蚌埠丰原医药科技发展有限公司 | 一种门冬氨酸鸟氨酸的缓释制剂及其制备工艺 |
| US10039735B2 (en) * | 2014-11-24 | 2018-08-07 | Ucl Business Plc | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| WO2016172112A1 (en) * | 2015-04-20 | 2016-10-27 | Ocera Therapeutics, Inc. | Formulations of l-ornithine phenylacetate |
| CA2995823A1 (en) * | 2015-08-18 | 2017-02-23 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| CA2998490A1 (en) * | 2015-09-25 | 2017-03-30 | Ocera Therapeutics, Inc. | Treatment and prevention of neuronal cell loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
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2016
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- 2016-11-11 SG SG11201802987UA patent/SG11201802987UA/en unknown
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- 2016-11-11 MX MX2018005088A patent/MX2018005088A/es unknown
- 2016-11-11 KR KR1020187016373A patent/KR20180086431A/ko active Search and Examination
- 2016-11-11 JP JP2018524369A patent/JP7294807B2/ja active Active
- 2016-11-11 CA CA3004331A patent/CA3004331A1/en not_active Abandoned
- 2016-11-11 WO PCT/US2016/061678 patent/WO2017083758A1/en active Application Filing
- 2016-11-11 BR BR112018009349A patent/BR112018009349A8/pt not_active Application Discontinuation
- 2016-11-11 RU RU2018113801A patent/RU2018113801A/ru not_active Application Discontinuation
- 2016-11-11 CN CN201680066488.5A patent/CN108366983A/zh active Pending
- 2016-11-11 EP EP16865158.6A patent/EP3373923A4/en not_active Withdrawn
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2018
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2021
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| JP7294807B2 (ja) | 2023-06-20 |
| BR112018009349A8 (pt) | 2019-02-26 |
| EP3373923A1 (en) | 2018-09-19 |
| IL258630B1 (en) | 2023-04-01 |
| CN113768863A (zh) | 2021-12-10 |
| SG11201802987UA (en) | 2018-05-30 |
| EP3373923A4 (en) | 2019-07-03 |
| MX2022001517A (es) | 2022-11-16 |
| AU2016353350B2 (en) | 2021-09-23 |
| JP2022058446A (ja) | 2022-04-12 |
| IL258630A (en) | 2018-06-28 |
| AU2016353350A1 (en) | 2018-05-10 |
| AU2021290236A1 (en) | 2022-02-10 |
| WO2017083758A1 (en) | 2017-05-18 |
| JP2018533601A (ja) | 2018-11-15 |
| CN108366983A (zh) | 2018-08-03 |
| KR20180086431A (ko) | 2018-07-31 |
| RU2018113801A (ru) | 2019-12-16 |
| IL258630B2 (en) | 2023-08-01 |
| BR112018009349A2 (pt) | 2018-11-13 |
| MX2018005088A (es) | 2019-05-16 |
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