AU2016353350B2 - Formulation of L-ornithine phenylacetate - Google Patents
Formulation of L-ornithine phenylacetate Download PDFInfo
- Publication number
- AU2016353350B2 AU2016353350B2 AU2016353350A AU2016353350A AU2016353350B2 AU 2016353350 B2 AU2016353350 B2 AU 2016353350B2 AU 2016353350 A AU2016353350 A AU 2016353350A AU 2016353350 A AU2016353350 A AU 2016353350A AU 2016353350 B2 AU2016353350 B2 AU 2016353350B2
- Authority
- AU
- Australia
- Prior art keywords
- phenylacetylglutamine
- plasma
- phenylacetate
- pharmaceutical formulation
- auco
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- LRSYFEZBIMVWRY-VWMHFEHESA-N (2s)-2,5-diaminopentanoic acid;2-phenylacetic acid Chemical compound NCCC[C@H](N)C(O)=O.OC(=O)CC1=CC=CC=C1 LRSYFEZBIMVWRY-VWMHFEHESA-N 0.000 title claims abstract description 75
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- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 198
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims description 87
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2021290236A AU2021290236A1 (en) | 2015-11-13 | 2021-12-21 | Formulations of L-ornithine phenylacetate |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562255300P | 2015-11-13 | 2015-11-13 | |
| US62/255,300 | 2015-11-13 | ||
| US201662276754P | 2016-01-08 | 2016-01-08 | |
| US62/276,754 | 2016-01-08 | ||
| US15/133,087 US20160338982A1 (en) | 2015-04-20 | 2016-04-19 | Formulations of l-ornithine phenylacetate |
| US15/133,087 | 2016-04-19 | ||
| PCT/US2016/061678 WO2017083758A1 (en) | 2015-11-13 | 2016-11-11 | Formulation of l-ornithine phenylacetate |
Related Child Applications (1)
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|---|---|---|---|
| AU2021290236A Division AU2021290236A1 (en) | 2015-11-13 | 2021-12-21 | Formulations of L-ornithine phenylacetate |
Publications (2)
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| AU2016353350A1 AU2016353350A1 (en) | 2018-05-10 |
| AU2016353350B2 true AU2016353350B2 (en) | 2021-09-23 |
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| AU2016353350A Ceased AU2016353350B2 (en) | 2015-11-13 | 2016-11-11 | Formulation of L-ornithine phenylacetate |
| AU2021290236A Abandoned AU2021290236A1 (en) | 2015-11-13 | 2021-12-21 | Formulations of L-ornithine phenylacetate |
Family Applications After (1)
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| AU2021290236A Abandoned AU2021290236A1 (en) | 2015-11-13 | 2021-12-21 | Formulations of L-ornithine phenylacetate |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP3373923A4 (ko) |
| JP (2) | JP7294807B2 (ko) |
| KR (1) | KR20180086431A (ko) |
| CN (2) | CN113768863A (ko) |
| AU (2) | AU2016353350B2 (ko) |
| BR (1) | BR112018009349A8 (ko) |
| CA (1) | CA3004331A1 (ko) |
| IL (1) | IL258630B2 (ko) |
| MX (2) | MX2018005088A (ko) |
| RU (1) | RU2018113801A (ko) |
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| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| JP7266581B2 (ja) | 2017-08-14 | 2023-04-28 | アクセラ・ヘルス・インコーポレイテッド | 肝疾患の治療のためのアミノ酸組成物 |
| US10596136B2 (en) | 2018-06-20 | 2020-03-24 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
| MX2022004449A (es) * | 2019-10-16 | 2022-08-04 | Ocera Therapeutics Inc | Dosis y usos de fenilacetato de ornitina para el tratamiento de hiperamonemia. |
Citations (3)
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|---|---|---|---|---|
| WO2006056794A1 (en) * | 2004-11-26 | 2006-06-01 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| WO2010144498A2 (en) * | 2009-06-08 | 2010-12-16 | Ucl Business Plc | Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate |
| US8173706B2 (en) * | 2009-04-03 | 2012-05-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| GB0426141D0 (en) * | 2004-11-26 | 2004-12-29 | Ucl Biomedica Plc | Treatment |
| DE102007009243A1 (de) * | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets |
| AU2015221466B2 (en) | 2009-04-03 | 2017-02-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| AU2014250643B2 (en) | 2009-06-08 | 2016-07-14 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| EA028395B1 (ru) * | 2010-10-06 | 2017-11-30 | Осера Терапьютикс, Инк. | Способы получения фенилацетата l-орнитина |
| CN103705490B (zh) * | 2013-10-31 | 2016-08-17 | 蚌埠丰原医药科技发展有限公司 | 一种门冬氨酸鸟氨酸的缓释制剂及其制备工艺 |
| AU2016252382A1 (en) * | 2015-04-20 | 2017-11-02 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
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Patent Citations (3)
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|---|---|---|---|---|
| WO2006056794A1 (en) * | 2004-11-26 | 2006-06-01 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| US8173706B2 (en) * | 2009-04-03 | 2012-05-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| WO2010144498A2 (en) * | 2009-06-08 | 2010-12-16 | Ucl Business Plc | Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate |
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Also Published As
| Publication number | Publication date |
|---|---|
| CA3004331A1 (en) | 2017-05-18 |
| CN113768863A (zh) | 2021-12-10 |
| BR112018009349A2 (pt) | 2018-11-13 |
| AU2016353350A1 (en) | 2018-05-10 |
| IL258630B1 (en) | 2023-04-01 |
| JP2018533601A (ja) | 2018-11-15 |
| SG11201802987UA (en) | 2018-05-30 |
| MX2022001517A (es) | 2022-11-16 |
| JP7294807B2 (ja) | 2023-06-20 |
| CN108366983A (zh) | 2018-08-03 |
| EP3373923A1 (en) | 2018-09-19 |
| EP3373923A4 (en) | 2019-07-03 |
| WO2017083758A1 (en) | 2017-05-18 |
| AU2021290236A1 (en) | 2022-02-10 |
| RU2018113801A (ru) | 2019-12-16 |
| KR20180086431A (ko) | 2018-07-31 |
| BR112018009349A8 (pt) | 2019-02-26 |
| MX2018005088A (es) | 2019-05-16 |
| IL258630A (en) | 2018-06-28 |
| JP2022058446A (ja) | 2022-04-12 |
| IL258630B2 (en) | 2023-08-01 |
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