CA3004331A1 - Formulations of l-ornithine phenylacetate - Google Patents
Formulations of l-ornithine phenylacetate Download PDFInfo
- Publication number
- CA3004331A1 CA3004331A1 CA3004331A CA3004331A CA3004331A1 CA 3004331 A1 CA3004331 A1 CA 3004331A1 CA 3004331 A CA3004331 A CA 3004331A CA 3004331 A CA3004331 A CA 3004331A CA 3004331 A1 CA3004331 A1 CA 3004331A1
- Authority
- CA
- Canada
- Prior art keywords
- phenylacetylglutamine
- plasma
- pharmaceutical formulation
- phenylacetate
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- LRSYFEZBIMVWRY-VWMHFEHESA-N (2s)-2,5-diaminopentanoic acid;2-phenylacetic acid Chemical compound NCCC[C@H](N)C(O)=O.OC(=O)CC1=CC=CC=C1 LRSYFEZBIMVWRY-VWMHFEHESA-N 0.000 title claims abstract description 71
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- 231100000836 acute liver failure Toxicity 0.000 claims abstract description 5
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 206
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims description 88
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562255300P | 2015-11-13 | 2015-11-13 | |
| US62/255,300 | 2015-11-13 | ||
| US201662276754P | 2016-01-08 | 2016-01-08 | |
| US62/276,754 | 2016-01-08 | ||
| US15/133,087 US20160338982A1 (en) | 2015-04-20 | 2016-04-19 | Formulations of l-ornithine phenylacetate |
| US15/133,087 | 2016-04-19 | ||
| PCT/US2016/061678 WO2017083758A1 (en) | 2015-11-13 | 2016-11-11 | Formulation of l-ornithine phenylacetate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3004331A1 true CA3004331A1 (en) | 2017-05-18 |
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ID=58695607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3004331A Abandoned CA3004331A1 (en) | 2015-11-13 | 2016-11-11 | Formulations of l-ornithine phenylacetate |
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| EP (1) | EP3373923A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7294807B2 (cg-RX-API-DMAC7.html) |
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| BR112020002419A2 (pt) | 2017-08-14 | 2020-07-28 | Axcella Health Inc. | aminoácido para o tratamento de doença do fígado |
| CN112839643A (zh) | 2018-06-20 | 2021-05-25 | 胺细拉健康公司 | 用于治疗肌肉中脂肪浸润的组合物及方法 |
| PH12022550738A1 (en) * | 2019-10-16 | 2023-05-08 | Mallinckrodt Entpr Llc | Dosages and uses of ornithine phenylacetate for treating hyperammonemia |
| WO2024261477A1 (en) | 2023-06-20 | 2024-12-26 | Yaqrit Limited | Combination of tlr4 antagonist, ornithine and phenylacetate or phenylbutyrate |
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| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| MX2007006171A (es) * | 2004-11-26 | 2007-10-08 | Ucl Business Plc | Composiciones que comprenden ornitina y acetato. |
| GB0426141D0 (en) * | 2004-11-26 | 2004-12-29 | Ucl Biomedica Plc | Treatment |
| DE102007009243A1 (de) * | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets |
| EP3263100B1 (en) * | 2009-04-03 | 2020-04-01 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| AU2015221466B2 (en) * | 2009-04-03 | 2017-02-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| KR101715008B1 (ko) * | 2009-06-08 | 2017-03-22 | 유씨엘 비즈니스 피엘씨 | Ｌ―오르니틴 페닐아세테이트를 사용한 문맥압 항진증의 치료 및 간 기능 회복 |
| AU2014250643B2 (en) * | 2009-06-08 | 2016-07-14 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| EP2625162B1 (en) * | 2010-10-06 | 2019-03-13 | Ocera Therapeutics, Inc. | Methods of making l-ornithine phenyl acetate |
| CN102993037B (zh) * | 2012-11-20 | 2015-03-04 | 南京工业大学 | 一种l-鸟氨酸苯乙酸盐的制备方法 |
| CN103705490B (zh) * | 2013-10-31 | 2016-08-17 | 蚌埠丰原医药科技发展有限公司 | 一种门冬氨酸鸟氨酸的缓释制剂及其制备工艺 |
| CA2968544A1 (en) * | 2014-11-24 | 2016-06-02 | Ucl Business Plc | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| CA2983146C (en) * | 2015-04-20 | 2023-09-12 | Ocera Therapeutics, Inc. | Formulations of l-ornithine phenylacetate |
| EP3337473A4 (en) * | 2015-08-18 | 2019-04-17 | Ocera Therapeutics, Inc. | TREATMENT AND PREVENTION OF MUSCLE WOUND BY L-ORNITHIN IN COMBINATION WITH AT LEAST ONE PHENYL ACETATE AND PHENYL BUTYRATE |
| CA2998490A1 (en) * | 2015-09-25 | 2017-03-30 | Ocera Therapeutics, Inc. | Treatment and prevention of neuronal cell loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
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| JP7294807B2 (ja) | 2023-06-20 |
| EP3373923A1 (en) | 2018-09-19 |
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| BR112018009349A8 (pt) | 2019-02-26 |
| RU2018113801A (ru) | 2019-12-16 |
| AU2016353350A1 (en) | 2018-05-10 |
| AU2016353350B2 (en) | 2021-09-23 |
| MX2018005088A (es) | 2019-05-16 |
| WO2017083758A1 (en) | 2017-05-18 |
| BR112018009349A2 (pt) | 2018-11-13 |
| SG11201802987UA (en) | 2018-05-30 |
| MX389926B (es) | 2025-03-20 |
| JP2022058446A (ja) | 2022-04-12 |
| CN113768863A (zh) | 2021-12-10 |
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