KR20250023993A - L-오르니틴 페닐아세테이트의 제제 - Google Patents
L-오르니틴 페닐아세테이트의 제제 Download PDFInfo
- Publication number
- KR20250023993A KR20250023993A KR1020247042587A KR20247042587A KR20250023993A KR 20250023993 A KR20250023993 A KR 20250023993A KR 1020247042587 A KR1020247042587 A KR 1020247042587A KR 20247042587 A KR20247042587 A KR 20247042587A KR 20250023993 A KR20250023993 A KR 20250023993A
- Authority
- KR
- South Korea
- Prior art keywords
- phenylacetylglutamine
- plasma
- phenylacetate
- auc
- oral pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 165
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims description 85
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562255300P | 2015-11-13 | 2015-11-13 | |
| US62/255,300 | 2015-11-13 | ||
| US201662276754P | 2016-01-08 | 2016-01-08 | |
| US62/276,754 | 2016-01-08 | ||
| US15/133,087 US20160338982A1 (en) | 2015-04-20 | 2016-04-19 | Formulations of l-ornithine phenylacetate |
| US15/133,087 | 2016-04-19 | ||
| KR1020187016373A KR20180086431A (ko) | 2015-11-13 | 2016-11-11 | L-오르니틴 페닐아세테이트의 제제 |
| PCT/US2016/061678 WO2017083758A1 (en) | 2015-11-13 | 2016-11-11 | Formulation of l-ornithine phenylacetate |
Related Parent Applications (1)
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| EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
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| AU2015221466B2 (en) * | 2009-04-03 | 2017-02-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| CN106810464B (zh) * | 2009-04-03 | 2019-01-22 | 欧塞拉治疗有限公司 | L-鸟氨酸苯乙酸盐及其制备方法 |
| ES2517340T3 (es) * | 2009-06-08 | 2014-11-03 | Ucl Business Plc | Tratamiento de la hipertensión portal usando L-ornitina y fenilacetato |
| AU2014250643B2 (en) | 2009-06-08 | 2016-07-14 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| EP2625162B1 (en) * | 2010-10-06 | 2019-03-13 | Ocera Therapeutics, Inc. | Methods of making l-ornithine phenyl acetate |
| CN102993037B (zh) * | 2012-11-20 | 2015-03-04 | 南京工业大学 | 一种l-鸟氨酸苯乙酸盐的制备方法 |
| CN103705490B (zh) * | 2013-10-31 | 2016-08-17 | 蚌埠丰原医药科技发展有限公司 | 一种门冬氨酸鸟氨酸的缓释制剂及其制备工艺 |
| KR20230018526A (ko) * | 2014-11-24 | 2023-02-07 | 유씨엘 비즈니스 리미티드 | 암모니아-저감 치료를 이용한 간성상세포 활성화와 연관된 질병의 치료 |
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| JP6989495B2 (ja) * | 2015-09-25 | 2022-01-05 | オセラ セラピューティクス， インコーポレイテッド | Ｌ−オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる神経細胞喪失の治療および予防 |
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| IL258630A (en) | 2018-06-28 |
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| MX389926B (es) | 2025-03-20 |
| BR112018009349A8 (pt) | 2019-02-26 |
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| IL258630B1 (en) | 2023-04-01 |
| JP2018533601A (ja) | 2018-11-15 |
| AU2016353350A1 (en) | 2018-05-10 |
| CA3004331A1 (en) | 2017-05-18 |
| AU2021290236A1 (en) | 2022-02-10 |
| EP3373923A4 (en) | 2019-07-03 |
| RU2018113801A (ru) | 2019-12-16 |
| AU2016353350B2 (en) | 2021-09-23 |
| SG11201802987UA (en) | 2018-05-30 |
| EP3373923A1 (en) | 2018-09-19 |
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