CA2998635C - Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same - Google Patents

Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same Download PDF

Info

Publication number
CA2998635C
CA2998635C CA2998635A CA2998635A CA2998635C CA 2998635 C CA2998635 C CA 2998635C CA 2998635 A CA2998635 A CA 2998635A CA 2998635 A CA2998635 A CA 2998635A CA 2998635 C CA2998635 C CA 2998635C
Authority
CA
Canada
Prior art keywords
sample
plates
plate
thickness
spacers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2998635A
Other languages
English (en)
French (fr)
Other versions
CA2998635A1 (en
Inventor
Stephen Y. Chou
Wei Ding
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Essenlix Corp
Original Assignee
Essenlix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Essenlix Corp filed Critical Essenlix Corp
Publication of CA2998635A1 publication Critical patent/CA2998635A1/en
Application granted granted Critical
Publication of CA2998635C publication Critical patent/CA2998635C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A61B5/0836—Measuring rate of CO2 production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/091—Measuring volume of inspired or expired gases, e.g. to determine lung capacity
    • A61B5/093—Measuring volume of inspired or expired gases, e.g. to determine lung capacity the gases being exhaled into, or inhaled from, an expansible chamber, e.g. bellows or expansible bag
    • A61B5/0935—Recording apparatus specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • G01N33/4975—Physical analysis of biological material of gaseous biological material, e.g. breath other than oxygen, carbon dioxide or alcohol, e.g. organic vapours
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3569—Range sublocal, e.g. between console and disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics
    • A61M2230/43—Composition of exhalation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state
    • G01N2001/2244—Exhaled gas, e.g. alcohol detecting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state
    • G01N1/2273—Atmospheric sampling
    • G01N2001/2276—Personal monitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/144—Imaging characterised by its optical setup
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0106—General arrangement of respective parts
    • G01N2021/0118—Apparatus with remote processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0181—Memory or computer-assisted visual determination

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physiology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2998635A 2015-09-14 2016-09-14 Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same Active CA2998635C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562218455P 2015-09-14 2015-09-14
US62/218,455 2015-09-14
US201662293188P 2016-02-09 2016-02-09
US62/293,188 2016-02-09
US201662305123P 2016-03-08 2016-03-08
US62/305,123 2016-03-08
PCT/US2016/051794 WO2017048881A1 (en) 2015-09-14 2016-09-14 Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same

Publications (2)

Publication Number Publication Date
CA2998635A1 CA2998635A1 (en) 2017-03-23
CA2998635C true CA2998635C (en) 2021-08-24

Family

ID=58289909

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2998635A Active CA2998635C (en) 2015-09-14 2016-09-14 Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same

Country Status (14)

Country Link
US (4) US10132794B2 (cg-RX-API-DMAC7.html)
EP (1) EP3341724B1 (cg-RX-API-DMAC7.html)
JP (3) JP6594528B2 (cg-RX-API-DMAC7.html)
KR (2) KR20190057446A (cg-RX-API-DMAC7.html)
CN (2) CN111426822B (cg-RX-API-DMAC7.html)
AU (2) AU2016323072B2 (cg-RX-API-DMAC7.html)
CA (1) CA2998635C (cg-RX-API-DMAC7.html)
HK (1) HK1254027A1 (cg-RX-API-DMAC7.html)
IL (1) IL258100B2 (cg-RX-API-DMAC7.html)
MX (1) MX392709B (cg-RX-API-DMAC7.html)
MY (1) MY192651A (cg-RX-API-DMAC7.html)
PH (1) PH12018500557B1 (cg-RX-API-DMAC7.html)
RU (1) RU2728427C2 (cg-RX-API-DMAC7.html)
WO (1) WO2017048881A1 (cg-RX-API-DMAC7.html)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7003158B2 (ja) 2017-02-07 2022-01-20 エッセンリックス コーポレーション 圧縮開放流アッセイおよび使用
CN122234927A (zh) * 2017-02-08 2026-06-19 上海宜晟生物科技有限公司 通过控制温度的分子操作和检测
WO2018148470A1 (en) * 2017-02-08 2018-08-16 Essenlix Corporation Sample collection and handling for delayed analysis
CA3053114A1 (en) 2017-02-09 2018-08-16 Essenlix Corporation Assay using different spacing heights
JP7335816B2 (ja) * 2017-05-23 2023-08-30 エッセンリックス コーポレーション アッセイのための急速な試料温度変化
WO2019027963A1 (en) * 2017-07-31 2019-02-07 Essenlix Corporation REDUCED INTERFERENCE ASSAYS
US11209417B2 (en) 2017-10-12 2021-12-28 Carrot, Inc. Breath sensor apparatus and methods of use
US10807095B2 (en) 2017-10-26 2020-10-20 Essenlix Corporation Making and tracking assay card
EP3700420B1 (en) * 2017-10-26 2024-09-25 Essenlix Corporation Devices and methods for tissue and cell staining
US11237113B2 (en) 2017-10-26 2022-02-01 Essenlix Corporation Rapid pH measurement
CN111970970A (zh) * 2017-10-26 2020-11-20 Essenlix公司 血小板的快速测量
US11609224B2 (en) 2017-10-26 2023-03-21 Essenlix Corporation Devices and methods for white blood cell analyses
GB2568876A (en) * 2017-11-27 2019-06-05 Imperial Innovations Ltd Detection of biomarkers
WO2019118652A1 (en) * 2017-12-12 2019-06-20 Essenlix Corporation Sample manipulation and assay with rapid temperature change
JP2021512299A (ja) * 2018-01-25 2021-05-13 エッセンリックス コーポレーション 試料中の細胞および非細胞分析物の並行アッセイ法
WO2020009798A1 (en) * 2018-07-02 2020-01-09 Purdue Research Foundation Device for selective collection and condensation of exhaled breath
WO2020032029A1 (ja) * 2018-08-08 2020-02-13 パナソニック株式会社 検出装置の検出方法、制御システム、検出システム、及びプログラム
EP3837525A4 (en) * 2018-08-16 2023-03-08 Essenlix Corporation IMAGE-BASED TEST WITH INTELLIGENT CONTROL STRUCTURES
WO2020037305A1 (en) 2018-08-16 2020-02-20 Essenlix Corporation Cell analysis in body fluids, particularly blood
CN113260847B (zh) * 2018-08-23 2025-03-07 上海宜晟生物科技有限公司 测定板、分离片、过滤器以及样品沉积标志
CN113227755B (zh) * 2018-08-28 2025-06-27 上海宜晟生物科技有限公司 测定准确度改善
TWI666426B (zh) * 2018-10-26 2019-07-21 National Taiwan University Of Science And Technology 液面高度偵測方法
CN109283141B (zh) * 2018-11-02 2020-12-01 河北大学 一种去除水汽干扰的呼出气体光谱检测系统及方法
USD897555S1 (en) 2018-11-15 2020-09-29 Essenlix Corporation Assay card
USD898224S1 (en) 2018-11-15 2020-10-06 Essenlix Corporation Assay plate with sample landing mark
USD898221S1 (en) 2018-11-15 2020-10-06 Essenlix Corporation Assay plate
USD898939S1 (en) 2018-11-20 2020-10-13 Essenlix Corporation Assay plate with sample landing mark
CN113811768A (zh) * 2018-11-20 2021-12-17 Essenlix 公司 多路复用测定
USD893469S1 (en) 2018-11-21 2020-08-18 Essenlix Corporation Phone holder
USD910202S1 (en) 2018-11-21 2021-02-09 Essenlix Corporation Assay plate with sample landing mark
USD910203S1 (en) 2018-11-27 2021-02-09 Essenlix Corporation Assay plate with sample landing mark
USD893470S1 (en) 2018-11-28 2020-08-18 Essenlix Corporation Phone holder
USD912842S1 (en) 2018-11-29 2021-03-09 Essenlix Corporation Assay plate
WO2020132702A2 (en) * 2018-12-20 2020-06-25 Essenlix Corporation Assay sample cards and adaptors and use of the same (ii)
US11260943B2 (en) * 2019-01-09 2022-03-01 California Institute Of Technology Implantable micro-sensor to quantify dissolved inert gas
USD898222S1 (en) 2019-01-18 2020-10-06 Essenlix Corporation Assay card
EP3948226A4 (en) * 2019-04-05 2023-09-06 Essenlix Corporation TEST ACCURACY AND RELIABILITY IMPROVEMENT
USD1003453S1 (en) 2019-05-14 2023-10-31 Essenlix Corporation Assay card hinge
CN110441250B (zh) * 2019-06-13 2021-11-09 吉林大学 一种双酶共固定铜纳米花材料的制备方法及在葡萄糖检测中的应用
US11933720B2 (en) * 2019-06-20 2024-03-19 Essenlix Corporation Optical transmission sample holder and analysis at multiple wavelengths
WO2021011944A2 (en) * 2019-07-18 2021-01-21 Essenlix Corporation Imaging based homogeneous assay
US11712177B2 (en) * 2019-08-12 2023-08-01 Essenlix Corporation Assay with textured surface
US11957451B2 (en) 2019-12-31 2024-04-16 Pivot Health Technologies Inc. Breath sensor calibration methods and apparatus
WO2022148549A1 (en) 2020-01-14 2022-07-14 Babylat Gmbh Apparatus and method for obtaining protein-enriched fractions from breast milk
GB2591133A (en) * 2020-01-17 2021-07-21 Imp College Innovations Ltd Cancer
US12533047B2 (en) 2020-04-19 2026-01-27 John J. Daniels Mask-based diagnostic system using exhaled breath condensate
US12442726B2 (en) 2020-04-19 2025-10-14 John J. Daniels Mask-based testing system for detecting biomarkers in exhaled breath condensate, aerosols and gases
US12031982B2 (en) * 2020-04-19 2024-07-09 John J. Daniels Using exhaled breath condensate for testing for a biomarker of COVID-19
US12369816B2 (en) 2020-04-19 2025-07-29 John J. Daniels Mask-based diagnostic system using exhaled breath condensate
CN116472116A (zh) * 2020-06-10 2023-07-21 10X基因组学有限公司 流体输送方法
EP4164796A4 (en) * 2020-06-10 2024-03-06 10x Genomics, Inc. Fluid delivery methods
US10991190B1 (en) 2020-07-20 2021-04-27 Abbott Laboratories Digital pass verification systems and methods
MX2023002215A (es) 2020-09-03 2023-05-17 Jfe Steel Corp Metodo para fabricar un articulo conformado por prensado y dispositivo de conformacion por prensado.
US11864860B2 (en) * 2020-09-14 2024-01-09 Christian Heislop Biometric imaging and biotelemetry system
US20240011908A1 (en) * 2020-10-29 2024-01-11 Essenlix Corporation Rapid Pathology or Cytology, Particularly Without Wash
WO2022136848A1 (en) * 2020-12-22 2022-06-30 Oxford Immune Algorithmics Ltd Wafer for carrying biological sample
MX2023012736A (es) 2021-04-30 2023-11-09 Root Applied Sciences Inc Dispositivo para recoger material del aire.
US20230059908A1 (en) * 2021-08-20 2023-02-23 Covidien Lp Ventilation monitoring systems and methods
US12453827B2 (en) 2022-02-24 2025-10-28 Yale University Nebulizer gas scavenger system with medication recycling and consumption metering
US20240347190A1 (en) 2023-04-17 2024-10-17 John J. Daniels Mask-based diagnostic utilizing ai algorithms for improved patient outcomes

Family Cites Families (207)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3368872A (en) 1964-08-31 1968-02-13 Scientific Industries Automatic chemical analyzer
US4066412A (en) 1966-04-26 1978-01-03 E. I. Du Pont De Nemours And Company Automatic clinical analyzer
US3447863A (en) 1966-07-11 1969-06-03 Sodell Research & Dev Co Method for preparing a slide for viewing
US4054646A (en) * 1973-07-30 1977-10-18 General Electric Method and apparatus for detection of antibodies and antigens
US3895661A (en) 1972-08-18 1975-07-22 Pfizer Cuvette apparatus for testing a number of reactants
US3992158A (en) 1973-08-16 1976-11-16 Eastman Kodak Company Integral analytical element
US4022521A (en) * 1974-02-19 1977-05-10 Honeywell Inc. Microscope slide
US3925166A (en) 1974-09-06 1975-12-09 Us Health Automated system for the determination of bacterial antibiotic susceptibilities
SE399768B (sv) 1975-09-29 1978-02-27 Lilja Jan E Kyvett for provtagning, blandning av, provet med ett reagensmedel och direkt utforande av, serskilt optisk, analys av det med reagensmedlet blandade provet
JPS548726A (en) 1977-06-20 1979-01-23 Monsanto Co Deodorizing agent
US4171866A (en) 1978-04-20 1979-10-23 Tolles Walter E Disposable volumetric slide
DE2932973A1 (de) 1978-08-14 1980-02-28 Fuji Photo Film Co Ltd Integrales mehrschichtiges material fuer die chemische analyse des blutes
US4233029A (en) 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
US4258001A (en) 1978-12-27 1981-03-24 Eastman Kodak Company Element, structure and method for the analysis or transport of liquids
US4329054A (en) 1979-08-16 1982-05-11 Spectron Development Laboratories, Inc. Apparatus for sizing particles, droplets or the like with laser scattering
IL58559A (en) 1979-10-25 1983-03-31 Porath Furedi Asher Method and apparatus for measuring the motility of sperm cells
IT1133964B (it) 1980-10-21 1986-07-24 Pietro Nardo Apparecchio per la misurazione densitometrica di frazioni proteiche separate per elettroforesi
JPS57101761A (en) 1980-12-17 1982-06-24 Konishiroku Photo Ind Co Ltd Analyzing element
FR2565350B1 (fr) 1984-06-05 1986-10-10 Paris Nord Universite Moyens propres a permettre le support, le traitement, le stockage et l'analyse automatiques en continu d'echantillons biologiques
US4745075A (en) 1984-09-06 1988-05-17 Burroughs Wellcome Co. Diagnostic test methods
US4596695A (en) 1984-09-10 1986-06-24 Cottingham Hugh V Agglutinographic reaction chamber
US4806311A (en) 1985-08-28 1989-02-21 Miles Inc. Multizone analytical element having labeled reagent concentration zone
US4906439A (en) 1986-03-25 1990-03-06 Pb Diagnostic Systems, Inc. Biological diagnostic device and method of use
JPS6380216A (ja) 1986-09-24 1988-04-11 Bio Meito:Kk プラスチツク製スライドグラス類
US5132097A (en) 1987-02-11 1992-07-21 G.D. Research Apparatus for analysis of specific binding complexes
US5002736A (en) 1987-03-31 1991-03-26 Fisher Scientific Co. Microscope slide and slide assembly
DE3721237A1 (de) 1987-06-27 1989-01-05 Boehringer Mannheim Gmbh Diagnostischer testtraeger und verfahren zu dessen herstellung
US5431880A (en) 1987-07-06 1995-07-11 Kramer; Donald L. Light transmittance type analytical system and variable transmittance optical component and test device for use therein
US5039487A (en) 1987-12-22 1991-08-13 Board Of Regents, The University Of Texas System Methods for quantifying components in liquid samples
US4950455A (en) 1987-12-22 1990-08-21 Board Of Regents, University Of Texas System Apparatus for quantifying components in liquid samples
US4911782A (en) 1988-03-28 1990-03-27 Cyto-Fluidics, Inc. Method for forming a miniaturized biological assembly
FR2630827B1 (fr) * 1988-04-28 1994-06-03 Oris Ind Dispositif et procede pour la determination qualitative et quantitative rapide de la presence d'un ligand reactif dans un fluide
US5281540A (en) 1988-08-02 1994-01-25 Abbott Laboratories Test array for performing assays
US5188968A (en) 1989-12-28 1993-02-23 Olympus Optical Co., Ltd. Method and reaction kit for agglutination detection
DE4013586C2 (de) 1990-04-27 1994-08-18 Suzuki Motor Co Vorrichtung zur Feststellung der immunologischen Agglutination
US5122284A (en) 1990-06-04 1992-06-16 Abaxis, Inc. Apparatus and method for optically analyzing biological fluids
WO1991020009A1 (en) 1990-06-15 1991-12-26 Doody Michael C Improved method and device for use of microspheres in microscopy and for quantifying the post coital test
EP0479231B1 (en) 1990-10-01 1996-03-27 Canon Kabushiki Kaisha Apparatus and method for measuring specimen
US5998220A (en) 1991-05-29 1999-12-07 Beckman Coulter, Inc. Opposable-element assay devices, kits, and methods employing them
US5413732A (en) 1991-08-19 1995-05-09 Abaxis, Inc. Reagent compositions for analytical testing
US5321975A (en) 1991-10-04 1994-06-21 Levine Robert A Differential erythrocyte counts
JPH05288754A (ja) 1992-04-10 1993-11-02 B M L:Kk 検体自動分取分配方法とシステム並びに検体表示方法
US5223219A (en) 1992-04-10 1993-06-29 Biotrack, Inc. Analytical cartridge and system for detecting analytes in liquid samples
US5306467A (en) 1993-02-17 1994-04-26 Hamilton-Thorn Research Apparatus for measurement of cell concentration in a biological sample employing a magnetic slide loading apparatus
US5594808A (en) 1993-06-11 1997-01-14 Ortho Diagnostic Systems Inc. Method and system for classifying agglutination reactions
US5518892A (en) 1994-02-23 1996-05-21 Idexx Laboratories, Inc. Apparatus and method for quantification of biological material in a liquid sample
US5656499A (en) 1994-08-01 1997-08-12 Abbott Laboratories Method for performing automated hematology and cytometry analysis
US5504011A (en) 1994-10-21 1996-04-02 International Technidyne Corporation Portable test apparatus and associated method of performing a blood coagulation test
JPH08178926A (ja) 1994-10-25 1996-07-12 Sumitomo Pharmaceut Co Ltd イムノアッセイプレートおよびその用途
NL9500281A (nl) 1995-02-15 1996-09-02 Jan Pieter Willem Vermeiden Telkamer voor biologisch onderzoek alsmede werkwijze voor de vervaardiging van een dergelijke telkamer.
US5623415A (en) 1995-02-16 1997-04-22 Smithkline Beecham Corporation Automated sampling and testing of biological materials
US5879628A (en) 1996-05-06 1999-03-09 Helena Laboratories Corporation Blood coagulation system having a bar code reader and a detecting means for detecting the presence of reagents in the cuvette
JP3609207B2 (ja) 1996-05-31 2005-01-12 Ｙｋｋ株式会社 生分解性面ファスナー
EP0929658A4 (en) 1996-08-26 2005-11-02 Univ Princeton REVERSIBLE SEALABLE DEVICE FOR SORTING MICROSTRUCTURES
IT1286838B1 (it) 1996-09-25 1998-07-17 Consiglio Nazionale Ricerche Metodo per la raccolta di immagini in microscopia confocale
US5858648A (en) 1996-11-04 1999-01-12 Sienna Biotech, Inc. Assays using reference microparticles
SE9604519D0 (sv) * 1996-12-09 1996-12-09 Noster System Ab Anordning för infångning och bestämning av koldioxid och sätt för dess användning
CN1188217A (zh) 1997-01-16 1998-07-22 楼世竹 正向循环热泵
EP0905514B1 (en) 1997-09-27 2003-11-26 Horiba, Ltd. Blood cell count/immunoassay apparatus using whole blood
US20060057573A1 (en) * 2002-02-15 2006-03-16 Somalogic, Inc Methods and reagents for detecting target binding by nucleic acid ligands
US6723290B1 (en) 1998-03-07 2004-04-20 Levine Robert A Container for holding biologic fluid for analysis
US6022734A (en) 1998-03-07 2000-02-08 Wardlaw Partners, L.P. Disposable apparatus for determining antibiotic sensitivity of bacteria
US6929953B1 (en) 1998-03-07 2005-08-16 Robert A. Levine Apparatus for analyzing biologic fluids
US6235536B1 (en) 1998-03-07 2001-05-22 Robert A. Levine Analysis of quiescent anticoagulated whole blood samples
US6004821A (en) 1998-03-07 1999-12-21 Levine; Robert A. Method and apparatus for performing chemical, qualitative, quantitative, and semi-quantitative analyses of a urine sample
US6350613B1 (en) 1998-03-07 2002-02-26 Belton Dickinson & Co. Determination of white blood cell differential and reticulocyte counts
US5948686A (en) 1998-03-07 1999-09-07 Robert A. Leuine Method for performing blood cell counts
DE19827754C1 (de) 1998-06-23 2000-02-10 Graffinity Pharm Design Gmbh Einrichtung für eine nahezu gleichzeitige Synthese einer Vielzahl von Proben
US6180314B1 (en) 1998-05-27 2001-01-30 Becton, Dickinson And Company Method for preparing thin liquid samples for microscopic analysis
US6358475B1 (en) 1998-05-27 2002-03-19 Becton, Dickinson And Company Device for preparing thin liquid for microscopic analysis
AU764964B2 (en) 1998-11-23 2003-09-04 Usamriid Purification method and apparatus
US7510841B2 (en) 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6806463B2 (en) * 1999-07-21 2004-10-19 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
DE19941905C2 (de) 1999-09-02 2002-06-06 Max Planck Gesellschaft Probenkammer zur Flüssigkeitsbehandlung biologischer Proben
NZ518740A (en) * 1999-11-08 2004-04-30 Univ Florida Marker detection method and apparatus to monitor drug compliance
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
AU2001242928A1 (en) 2000-03-16 2001-09-24 Biacore Ab Method for capturing analytes eluted from surface-bound ligands
CA2402737A1 (en) 2000-03-17 2001-09-27 Emanuele Ostuni Cell patterning technique
JP4606543B2 (ja) 2000-04-13 2011-01-05 パナソニック株式会社 光学特性計測装置における被検溶液量確認方法および計測系制御方法
US6852526B2 (en) 2000-07-14 2005-02-08 Transform Pharmaceuticals, Inc. Transdermal assay with magnetic clamp
US7410807B2 (en) 2000-07-24 2008-08-12 D Aurora Vito J Pregnancy and sex identification test based on saliva or other bodily fluids
US20020092340A1 (en) * 2000-10-30 2002-07-18 Veeco Instruments Inc. Cantilever array sensor system
SE0004297D0 (sv) 2000-11-23 2000-11-23 Gyros Ab Device for thermal cycling
US6714287B2 (en) 2001-01-02 2004-03-30 Becton, Dickinson And Company Apparatus for determining the volume of single red blood cells
US7435384B2 (en) * 2001-01-08 2008-10-14 Leonard Fish Diagnostic instrument with movable electrode mounting member and methods for detecting analytes
WO2002084266A2 (en) * 2001-04-11 2002-10-24 Rapid Biosensor Systems Limited Biological measurement system
US7076092B2 (en) 2001-06-14 2006-07-11 The United States Of America As Represented By The United States Department Of Energy High-throughput, dual probe biological assays based on single molecule detection
US7179423B2 (en) 2001-06-20 2007-02-20 Cytonome, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
DE10137565B4 (de) * 2001-07-30 2004-07-15 Filt Lungen- Und Thoraxdiagnostik Gmbh Verfahren zur Bestimmung von Parametern eines Atemkondensats
AU2002365249A1 (en) 2001-08-15 2003-09-02 The Board Of Trustees Of The University Of Illinois Elastomeric stencils for micropatterning cells
US6939032B2 (en) 2001-10-25 2005-09-06 Erie Scientific Company Cover slip mixing apparatus
US7943093B2 (en) 2001-12-12 2011-05-17 Erie Scientific Company Cover slip
US20080021339A1 (en) 2005-10-27 2008-01-24 Gabriel Jean-Christophe P Anesthesia monitor, capacitance nanosensors and dynamic sensor sampling method
US20070237676A1 (en) * 2002-04-15 2007-10-11 Colton Jonathan S Polymer micro-cantilever with probe tip and method for making same
US20060160134A1 (en) * 2002-10-21 2006-07-20 Melker Richard J Novel application of biosensors for diagnosis and treatment of disease
EP1563100B1 (en) 2002-11-01 2013-04-24 Iris Molecular Diagnostics, Inc. Displacement sandwich immuno-pcr
ES2527408T3 (es) 2002-12-03 2015-01-23 North Carolina State University Ligandos de proteínas priones y procedimientos de uso
US7828741B2 (en) * 2002-12-20 2010-11-09 The Charlotte-Mecklenburg Hospital Authority Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
AU2003299850A1 (en) * 2002-12-20 2004-07-22 Amidex, Inc. Breath aerosol collection system and method
US20040138577A1 (en) * 2002-12-20 2004-07-15 Kline Jeffrey A. Disposable hand-held device for collection of exhaled breath condensate
WO2004073497A2 (en) * 2003-02-14 2004-09-02 The Charlotte-Mecklenburg Hospital Authority Device and method for collection of exhaled alveolar breath condensate
US7510848B2 (en) 2003-04-04 2009-03-31 North Carolina State University Prion protein binding materials and methods of use
JP4783727B2 (ja) 2003-04-04 2011-09-28 パソゲン リムーバル アンド ダイアグノスティック テクノロジーズ インコーポレーテッド プリオンタンパク質結合物質と使用法
JP2006524340A (ja) 2003-04-14 2006-10-26 アメリカン ナショナル レッド クロス タンパク質の構造アイソフォームに特異的なリガンドを特定するための方法
US7101341B2 (en) * 2003-04-15 2006-09-05 Ross Tsukashima Respiratory monitoring, diagnostic and therapeutic system
US20040214310A1 (en) 2003-04-25 2004-10-28 Parker Russell A. Apparatus and method for array alignment
AU2004236740A1 (en) 2003-05-02 2004-11-18 Sigma-Aldrich Co. Solid phase cell lysis and capture platform
JP4400778B2 (ja) 2003-08-08 2010-01-20 株式会社エンプラス プラスチックプレート及びプレート
AU2004294342A1 (en) * 2003-12-01 2005-06-16 Sierra Medical Technology, Inc. A respiratory monitoring, diagnostic and therapeutic system
US7468160B2 (en) 2003-12-05 2008-12-23 Agilent Technologies, Inc. Devices and methods for performing array based assays
WO2005100539A2 (en) 2004-04-07 2005-10-27 Levine, Robert, A. Disposable chamber for analyzing biologic fluids
DE102004041595A1 (de) * 2004-04-30 2005-12-01 Markus Gruber Messzelle sowie Verfahren zum Herstellen einer Messzelle und Messvorrichtung zur Aufnahme einer derartigen Messzelle
US20050254995A1 (en) 2004-05-12 2005-11-17 Harvard Apparatus, Inc. Devices and methods to immobilize analytes of interest
CA2565981C (en) 2004-05-13 2015-02-17 Advanced Animal Diagnostics Microfluidic device and leucocyte antigen mediated microfluidic assay
AP2006003861A0 (en) * 2004-06-09 2006-12-31 Pathogen Removal And Diagnosti Particles embedded in a porous substrate for removing target analyte from a sample
US20060015157A1 (en) 2004-07-14 2006-01-19 Leong Vong V Method and apparatus for particle radiation therapy and practice of particle medicine
WO2007001342A2 (en) * 2004-08-20 2007-01-04 University Of Virginia Patent Foundation Exhaled breath condensate collection and assay system and method
WO2006026248A1 (en) 2004-08-25 2006-03-09 Sigma-Aldrich Co. Compositions and methods employing zwitterionic detergent combinations
JP2006071475A (ja) * 2004-09-02 2006-03-16 Hakuju Inst For Health Science Co Ltd 血液観察用試料台、及び血液細胞の分離定量評価方法
US7481980B2 (en) 2004-09-08 2009-01-27 Intavis Bioanalytical Instruments Ag Device for staining and hybridization reactions
JP4645110B2 (ja) * 2004-09-15 2011-03-09 ソニー株式会社 誘電泳動を利用するハイブリダイゼーション検出部と該検出部を備えるセンサーチップ、並びにハイブリダイゼーション検出方法
US7547424B2 (en) 2004-09-21 2009-06-16 Van Andel Research Institute Method and apparatus for making partitioned slides
US20060090658A1 (en) 2004-11-01 2006-05-04 Michael Phillips Tissue marking system
US8594768B2 (en) 2004-11-01 2013-11-26 Michael J. Phillips Surgical system with clips for identifying the orientation of a tissue sample
ES2550177T3 (es) 2004-11-03 2015-11-05 Iris Molecular Diagnostics, Inc. Microburbujas para concentración de afinidad
CN101137758B (zh) 2004-11-03 2012-10-10 意力速分子诊断股份有限公司 均相分析物检测
US7765854B2 (en) * 2004-11-16 2010-08-03 Exxonmobil Research And Engineering Company Microcantilever stress sensor for fluid analysis
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US8399055B2 (en) * 2005-07-21 2013-03-19 Rania Bakry Open channel solid phase extraction systems and methods
US7731901B2 (en) 2005-10-19 2010-06-08 Abbott Laboratories Apparatus and method for performing counts within a biologic fluid sample
WO2007054903A2 (en) 2005-11-08 2007-05-18 Ecole Polytechnique Federale De Lausanne (Epfl) Hyperbranched polymer for micro devices
EP1963853B1 (en) 2005-12-21 2016-03-09 Meso Scale Technologies, LLC Assay modules having assay reagents and methods of making and using same
US20090233329A1 (en) 2006-03-24 2009-09-17 Rodriguez Rodolfo R Microfluidic chamber assembly for mastitis assay
US20080003667A1 (en) 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
US7914460B2 (en) * 2006-08-15 2011-03-29 University Of Florida Research Foundation, Inc. Condensate glucose analyzer
US20120107799A1 (en) 2010-10-29 2012-05-03 Longhorn Vaccines & Diagnostics LLC. Disposable, rapid extraction apparatus and methods
US8252598B2 (en) * 2006-11-27 2012-08-28 University Of South Carolina Method of sensing chemical and bio-molecular analytes and sensing system using a microcantilever
US7802467B2 (en) 2006-12-22 2010-09-28 Abbott Diabetes Care Inc. Analyte sensors and methods of use
US7738094B2 (en) 2007-01-26 2010-06-15 Becton, Dickinson And Company Method, system, and compositions for cell counting and analysis
WO2008122310A1 (en) 2007-04-04 2008-10-16 Chimera Biotec Gmbh Method for the detection of an analyte in biological matrix
JP5214723B2 (ja) 2007-04-30 2013-06-19 ナノゲン・インコーポレイテッド 多分析物アッセイ
CA2946024C (en) 2007-05-03 2020-06-02 Clondiag Gmbh Devices and methods for detecting analytes
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
CN101827558B (zh) * 2007-10-02 2013-03-27 安娜-卡林·奥林 呼出的粒子的采集和测量
US8906700B2 (en) 2007-11-06 2014-12-09 Ambergen, Inc. Methods and compositions for phototransfer
US7802466B2 (en) * 2007-11-28 2010-09-28 Sierra Sensors Gmbh Oscillating sensor and fluid sample analysis using an oscillating sensor
US8058073B2 (en) 2008-01-30 2011-11-15 Ortho-Clinical Diagnostics, Inc. Immunodiagnostic test cards having indicating indicia
PL2252893T3 (pl) 2008-02-21 2014-03-31 Iris Int Inc Sposób wczesnego określenia nawrotu po leczeniu nowotworu gruczołu krokowego
CN102016578B (zh) 2008-03-21 2014-10-01 艾博特健康公司 利用红细胞内含有的血红蛋白的本征色素沉着来确定血样的血细胞比容的方法及设备
EP2265945B1 (en) 2008-03-21 2012-11-07 Abbott Point Of Care, Inc. Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells
CN102016686B (zh) 2008-03-21 2015-03-25 艾博特健康公司 确定对生物样本成像的成像装置的焦点位置的方法和设备
US9638912B2 (en) 2008-03-21 2017-05-02 Abbott Point Of Care, Inc. Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample
ES2560098T3 (es) 2008-03-21 2016-02-17 Abbott Point Of Care, Inc. Método y aparato para detectar y contar plaquetas individualmente y en agregados
ES2588223T3 (es) 2008-03-21 2016-10-31 Abbott Point Of Care, Inc. Procedimiento para el análisis de células individuales o partículas en la sangre usando fluorescencia y absorción de un colorante
WO2009124179A1 (en) 2008-04-02 2009-10-08 Abbott Point Of Care, Inc. Virtual separation of bound and free label in a ligand assay for performing immunoassays of biological fluids, including whole blood
WO2009126800A1 (en) 2008-04-09 2009-10-15 Abbott Point Of Care, Inc. Method for measuring the area of a sample disposed within an analysis chamber
WO2009126505A1 (en) 2008-04-09 2009-10-15 Abbott Point Of Care, Inc. Method of detecting very low levels of analyte within a thin film fluid sample contained in a thin thickness chamber
US8176768B2 (en) * 2008-07-04 2012-05-15 Ngk Insulators, Ltd. Particulate matter detection device
CN102131737B (zh) 2008-08-21 2014-03-19 西门子医疗保健诊断公司 用于尿沉渣分析的多层载玻片
US8312759B2 (en) * 2009-02-17 2012-11-20 Mcalister Technologies, Llc Methods, devices, and systems for detecting properties of target samples
US20120108787A1 (en) 2009-02-26 2012-05-03 Nubiome, Inc. Immobilization Particles for Removal of Microorganisms and/or Chemicals
US8394030B2 (en) * 2009-03-18 2013-03-12 Carefusion 207, Inc. Exhaled breath condensate biometric marker measurement apparatus and method
US9395365B2 (en) 2009-04-02 2016-07-19 Abbott Point Of Care, Inc. Detection of infectious disease in a human or animal by measuring specific phagocytosis in a thin film sample of their anticoagulated blood
US20100255605A1 (en) 2009-04-02 2010-10-07 Abbott Point Of Care, Inc. Method and device for transferring biologic fluid samples
EP2417436A1 (de) * 2009-04-09 2012-02-15 Bayer Cropscience AG Vorrichtung und verfahren zum nachweis und zur quantitativen analyse von analyten insbesondere mykotoxinen
DE102009016712A1 (de) * 2009-04-09 2010-10-14 Bayer Technology Services Gmbh Einweg-Mikrofluidik-Testkassette zur Bioassay von Analyten
US9445748B2 (en) * 2009-09-30 2016-09-20 Mti Medtech Innovation Gmbh Device and method for fractionally collecting contents of exhaled air
JP5652847B2 (ja) * 2009-11-10 2015-01-14 公益財団法人北九州産業学術推進機構 呼気分析の方法
EP2499500B1 (en) 2009-11-13 2020-12-30 Ventana Medical Systems, Inc. Thin film processing apparatuses for adjustable volume accommodation
EP2826564B1 (en) 2009-11-23 2018-12-26 3M Innovative Properties Company Microwell array articles and methods of use
US9579651B2 (en) 2009-12-18 2017-02-28 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge
ES2438841T3 (es) 2009-12-31 2014-01-20 Abbott Point Of Care, Inc. Método y aparato para determinar el volumen celular medio de los glóbulos rojos en la sangre
WO2011102903A1 (en) 2010-02-18 2011-08-25 Bima Limited Immobilised-bead immunomultiplex assay
US8472693B2 (en) 2010-03-18 2013-06-25 Abbott Point Of Care, Inc. Method for determining at least one hemoglobin related parameter of a whole blood sample
WO2011123649A1 (en) 2010-03-31 2011-10-06 Abbott Point Of Care, Inc. Method and apparatus for selectively admixing reagents in a substantially undiluted biologic fluid sample analysis
US9199233B2 (en) 2010-03-31 2015-12-01 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge with deflecting top panel
TWI497072B (zh) * 2010-04-28 2015-08-21 Panasonic Corp 化學感測器
WO2012002515A1 (ja) * 2010-06-30 2012-01-05 東ソー株式会社 粒子固定用構造体、及び、粒子解析装置
US8481282B2 (en) 2010-07-23 2013-07-09 Abbott Point Of Care, Inc. Method for detecting the presence of anisotropic crystals in undiluted whole blood
WO2012019118A1 (en) 2010-08-05 2012-02-09 Abbott Point Of Care, Inc. Method and apparatus for automated whole blood sample analyses from microscopy images
CA3139049C (en) 2010-10-14 2024-10-15 Meso Scale Technologies, Llc REAGENT STORAGE IN A TEST DEVICE
WO2012054588A2 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. Conduit-containing devices and methods for analyte processing and detection
US9469871B2 (en) 2011-04-14 2016-10-18 Corporos Inc. Methods and apparatus for point-of-care nucleic acid amplification and detection
US8717673B2 (en) 2011-05-28 2014-05-06 Board Of Trustees Of The University Of Illinois Simple ultra-stable stage with built-in fiduciary markers for fluorescence nanoscopy
CN105817276B (zh) 2011-08-24 2018-02-06 艾博特健康公司 生物流体样品分析盒
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US9046473B2 (en) 2011-09-28 2015-06-02 Abbott Point Of Care, Inc. Method and apparatus for detecting the presence of intraerythrocytic parasites
US9103766B2 (en) 2011-10-18 2015-08-11 Breath Diagnostics, Llc Device and method for monitoring and quantifying analytes
WO2013112898A1 (en) * 2012-01-25 2013-08-01 The Regents Of The University Of California Micro-analyzer with passive aggregator
US9689864B2 (en) 2012-02-01 2017-06-27 Invoy Technologies, Llc Method and apparatus for rapid quantification of an analyte in breath
US9822356B2 (en) 2012-04-20 2017-11-21 California Institute Of Technology Fluidic devices and systems for sample preparation or autonomous analysis
US9354159B2 (en) 2012-05-02 2016-05-31 Nanoscopia (Cayman), Inc. Opto-fluidic system with coated fluid channels
JP2014002046A (ja) * 2012-06-19 2014-01-09 Murazumi Kogyo Kk 液状試料検査用プレパラート
CN104823049A (zh) * 2012-10-01 2015-08-05 普林斯顿大学理事会 具有增强的光学信号的微流体传感器
EP2929345A4 (en) 2012-12-06 2015-11-18 Abbott Point Of Care Inc ILLUSTRATION OF BIOLOGICAL FLUIDS BY MEANS OF A PREFERRED DISTRIBUTION
US9518920B2 (en) 2013-06-26 2016-12-13 Alentic Microscience Inc. Sample processing improvements for microscopy
US11029310B2 (en) * 2013-03-14 2021-06-08 Wisconsin Alumni Research Foundation Device and method for extracting a targeted fraction from a sample
WO2014153099A2 (en) * 2013-03-14 2014-09-25 Pulmonary Analytics Method for using exhaled breath to determine the presence of drug
US10656149B2 (en) 2013-03-15 2020-05-19 The Trustees Of Princeton University Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis
CN109342282A (zh) 2013-05-09 2019-02-15 艾博特健康公司 确定未裂解血液样本中基于血红蛋白的参数的方法和装置
US9347962B2 (en) 2013-08-05 2016-05-24 Nanoscopia (Cayman), Inc. Handheld diagnostic system with chip-scale microscope and automated image capture mechanism
US20150036131A1 (en) 2013-08-05 2015-02-05 Nanoscopia ( Cayman), Inc. Handheld diagnostic system with chip-scale microscope and disposable sample holder having built-in reference features
JP6417661B2 (ja) * 2013-12-19 2018-11-07 東洋紡株式会社 検鏡プレート
AU2016297866B2 (en) 2015-07-24 2021-10-21 Cepheid Molecular diagnostic assay system
NL2015287B1 (en) 2015-08-10 2017-02-28 Micronit Microfluidics Bv Channel for trapping particles to be fed to said channel with a fluid.
KR20190057445A (ko) 2015-09-14 2019-05-28 에센릭스 코프. 샘플 특히 혈액샘플을 분석하기 위한 장치와 시스템 및 그 사용 방법

Also Published As

Publication number Publication date
CN111426822A (zh) 2020-07-17
KR20180056420A (ko) 2018-05-28
CN108633304B (zh) 2020-08-14
CA2998635A1 (en) 2017-03-23
US10132794B2 (en) 2018-11-20
AU2019222844B2 (en) 2021-02-25
MX2018003147A (es) 2018-09-06
WO2017048881A1 (en) 2017-03-23
IL258100B2 (en) 2023-04-01
AU2016323072B2 (en) 2019-09-19
US20210041416A1 (en) 2021-02-11
US20190361002A1 (en) 2019-11-28
MX392709B (es) 2025-03-24
US10830761B2 (en) 2020-11-10
HK1254027A1 (zh) 2019-07-12
JP6594528B2 (ja) 2019-10-23
JP6796175B2 (ja) 2020-12-02
PH12018500557A1 (en) 2018-09-17
JP2021047187A (ja) 2021-03-25
US20180156775A1 (en) 2018-06-07
AU2016323072A1 (en) 2018-04-05
JP2018532999A (ja) 2018-11-08
EP3341724B1 (en) 2023-10-04
AU2019222844A1 (en) 2019-09-19
IL258100A (en) 2018-05-31
RU2018113369A (ru) 2019-10-18
RU2018113369A3 (cg-RX-API-DMAC7.html) 2019-10-18
US20190017996A1 (en) 2019-01-17
CN111426822B (zh) 2022-12-13
EP3341724A1 (en) 2018-07-04
IL258100B (en) 2022-12-01
JP2020008594A (ja) 2020-01-16
US10416151B2 (en) 2019-09-17
EP3341724A4 (en) 2019-04-24
KR20190057446A (ko) 2019-05-28
CN108633304A (zh) 2018-10-09
MY192651A (en) 2022-08-29
US11415570B2 (en) 2022-08-16
KR101982330B1 (ko) 2019-05-24
RU2728427C2 (ru) 2020-07-29
PH12018500557B1 (en) 2018-09-17

Similar Documents

Publication Publication Date Title
US11415570B2 (en) Rapid vapor condensate collection and analysis
US12276660B2 (en) Device and system for analyzing a sample, particularly blood, as well as methods of using the same
EP3335042B1 (en) Bio/chemical assay devices and methods for simplified steps, small samples, accelerated speed, and ease-of-use
US20210356462A1 (en) Multiplex assay

Legal Events

Date Code Title Description
MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 8TH ANNIV.) - STANDARD

Year of fee payment: 8

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240726

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20240726

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 9TH ANNIV.) - STANDARD

Year of fee payment: 9

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250702

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250702

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 10TH ANNIV.) - STANDARD

Year of fee payment: 10

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20260701

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20260702