CA2997971A1 - Variants of activin iib receptor polypeptides and uses thereof - Google Patents

Variants of activin iib receptor polypeptides and uses thereof Download PDF

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Publication number
CA2997971A1
CA2997971A1 CA2997971A CA2997971A CA2997971A1 CA 2997971 A1 CA2997971 A1 CA 2997971A1 CA 2997971 A CA2997971 A CA 2997971A CA 2997971 A CA2997971 A CA 2997971A CA 2997971 A1 CA2997971 A1 CA 2997971A1
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Canada
Prior art keywords
polypeptide
seq
activin
substitution
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2997971A
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English (en)
French (fr)
Inventor
Thomas C. Boone
Rohini Deshpande
Hq Han
Yue-Sheng Li
Mark Leo Michaels
Jeonghoon Sun
Lei-Ting Tony Tam
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Amgen Inc
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Amgen Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41693455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2997971(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA2997971A1 publication Critical patent/CA2997971A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
CA2997971A 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof Abandoned CA2997971A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20025008P 2008-11-26 2008-11-26
US61/200,250 2008-11-26
US25906009P 2009-11-06 2009-11-06
US61/259,060 2009-11-06
CA2743850A CA2743850C (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2743850A Division CA2743850C (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof

Publications (1)

Publication Number Publication Date
CA2997971A1 true CA2997971A1 (en) 2010-06-03

Family

ID=41693455

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CA2997971A Abandoned CA2997971A1 (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof
CA2743850A Expired - Fee Related CA2743850C (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof

Family Applications After (1)

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CA2743850A Expired - Fee Related CA2743850C (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof

Country Status (37)

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US (5) US8410043B2 (enExample)
EP (2) EP2370463B1 (enExample)
JP (3) JP5611222B2 (enExample)
KR (3) KR20170105124A (enExample)
CN (2) CN104371024A (enExample)
AR (1) AR074397A1 (enExample)
AU (1) AU2009320364B2 (enExample)
BR (1) BRPI0920962A2 (enExample)
CA (2) CA2997971A1 (enExample)
CL (1) CL2011001239A1 (enExample)
CO (1) CO6382163A2 (enExample)
CR (2) CR20160443A (enExample)
CY (1) CY1118754T1 (enExample)
DK (1) DK2370463T3 (enExample)
EA (2) EA201100832A1 (enExample)
ES (1) ES2600491T3 (enExample)
HR (1) HRP20161450T1 (enExample)
HU (1) HUE032090T2 (enExample)
IL (2) IL212773A (enExample)
LT (1) LT2370463T (enExample)
MA (1) MA32936B1 (enExample)
ME (1) ME02652B (enExample)
MX (1) MX2011005505A (enExample)
MY (1) MY159483A (enExample)
NZ (2) NZ627111A (enExample)
PE (2) PE20150680A1 (enExample)
PL (1) PL2370463T3 (enExample)
PT (1) PT2370463T (enExample)
RS (1) RS55369B1 (enExample)
SG (2) SG10201703067QA (enExample)
SI (1) SI2370463T1 (enExample)
SM (1) SMT201600417B (enExample)
TN (1) TN2011000238A1 (enExample)
TW (1) TWI486166B (enExample)
UA (1) UA107921C2 (enExample)
WO (1) WO2010062383A2 (enExample)
ZA (1) ZA201104648B (enExample)

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HUE063136T2 (hu) 2008-08-14 2023-12-28 Acceleron Pharma Inc GDF-Csapdák
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TWI655207B (zh) * 2013-07-30 2019-04-01 再生元醫藥公司 抗活化素ａ之抗體及其用途
CN104693270B (zh) * 2013-12-10 2018-10-16 清华大学 一种用于融合蛋白的连接肽
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BR112017021510A2 (pt) 2015-04-06 2018-07-03 Acceleron Pharma Inc heteromultímeros do receptor tipo i e tipo ii da superfamília tgf-beta e sua utilização
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